(60 nodes) Regulation of peptidyl-serine phosphorylation network (Taeniopygia guttata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	OPRD1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	NSD1	Uncharacterized protein. (2836 aa)
	BAX	BCL2 associated X, apoptosis regulator. (225 aa)
	PINK1	PTEN induced kinase 1. (515 aa)
	LOC115491041	Uncharacterized protein. (225 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (893 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (342 aa)
	INPP5J	Inositol polyphosphate-5-phosphatase J. (607 aa)
	TENM1	Teneurin transmembrane protein 1. (2713 aa)
	BDNF	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (254 aa)
	ENSTGUP00000023077	annotation not available (179 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	TNKS1BP1	Tankyrase_bdg_C domain-containing protein. (1915 aa)
	LOC115491504	Cyclic nucleotide-binding domain-containing protein. (932 aa)
	APP	Amyloid beta precursor protein. (797 aa)
	CAPRIN2	C1q domain-containing protein. (1187 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1338 aa)
	BAG4	Uncharacterized protein. (340 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (263 aa)
	RAMP3	Receptor activity modifying protein 3. (191 aa)
	LOC105760863	Uncharacterized protein. (190 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (561 aa)
	ENSTGUP00000033742	annotation not available (1045 aa)
	SMYD3	SET and MYND domain containing 3. (239 aa)
	FNIP2	Folliculin interacting protein 2. (1157 aa)
	SH2D3C	SH2 domain containing 3C. (931 aa)
	STOX1	Stork_head domain-containing protein. (850 aa)
	GAS6	Growth arrest specific 6. (704 aa)
	MAPKAP1	MAPK associated protein 1. (551 aa)
	UCN	Urocortin. (99 aa)
	CNOT9	CCR4-NOT transcription complex subunit 9. (305 aa)
	LOC115491043	Interferon-like. (190 aa)
	LOC115491042	Interferon-like. (190 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (553 aa)
	LATS1	Large tumor suppressor kinase 1. (1138 aa)
	INPP5F	Uncharacterized protein. (1108 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	PWP1	WD_REPEATS_REGION domain-containing protein. (494 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (319 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LIF	LIF interleukin 6 family cytokine. (211 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	NCK2	NCK adaptor protein 2. (380 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1614 aa)
	LOC115496886	Protein kinase domain-containing protein. (554 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1104 aa)
	INPP5K	IPPc domain-containing protein. (475 aa)
	DDIT4	DNA damage inducible transcript 4. (192 aa)
	AXIN1	Axin 1. (841 aa)
	LOC100228379	Uncharacterized protein. (184 aa)
	HAX1	Uncharacterized protein. (275 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1358 aa)
	IL6	Interleukin 6. (221 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
	MAD2L2	HORMA domain-containing protein. (203 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1713 aa)
	PAQR3	Progestin and adipoQ receptor family member 3. (311 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (238 aa)
	SMAD7	MH1 domain-containing protein. (392 aa)
	CREBL2	BZIP domain-containing protein. (128 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	BDNF	ENSTGUP00000029357	ENSTGUP00000022002	Amyloid beta precursor protein.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.510
APP	IL6	ENSTGUP00000029357	ENSTGUP00000002805	Amyloid beta precursor protein.	Interleukin 6.	0.407
AXIN1	CAV3	ENSTGUP00000004469	ENSTGUP00000010724	Axin 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.438
BAG4	PINK1	ENSTGUP00000029811	ENSTGUP00000017401	Uncharacterized protein.	PTEN induced kinase 1.	0.409
BDNF	APP	ENSTGUP00000022002	ENSTGUP00000029357	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Amyloid beta precursor protein.	0.510
BDNF	IL6	ENSTGUP00000022002	ENSTGUP00000002805	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Interleukin 6.	0.725
BDNF	NTF3	ENSTGUP00000022002	ENSTGUP00000020409	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.940
CAV1	CAV3	ENSTGUP00000027745	ENSTGUP00000010724	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV3	AXIN1	ENSTGUP00000010724	ENSTGUP00000004469	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Axin 1.	0.438
CAV3	CAV1	ENSTGUP00000010724	ENSTGUP00000027745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CNOT9	TNKS1BP1	ENSTGUP00000038301	ENSTGUP00000028192	CCR4-NOT transcription complex subunit 9.	Tankyrase_bdg_C domain-containing protein.	0.702
DDIT4	RICTOR	ENSTGUP00000004592	ENSTGUP00000002201	DNA damage inducible transcript 4.	RPTOR independent companion of MTOR complex 2.	0.422
DDIT4	RPTOR	ENSTGUP00000004592	ENSTGUP00000003147	DNA damage inducible transcript 4.	Regulatory associated protein of MTOR complex 1.	0.540
ENSTGUP00000023077	SMYD3	ENSTGUP00000023077	ENSTGUP00000035361	annotation not available	SET and MYND domain containing 3.	0.900
ERCC6	MAD2L2	ENSTGUP00000008484	ENSTGUP00000002407	ERCC excision repair 6, chromatin remodeling factor.	HORMA domain-containing protein.	0.408
HGF	IL6	ENSTGUP00000002672	ENSTGUP00000002805	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Interleukin 6.	0.463
HGF	LIF	ENSTGUP00000002672	ENSTGUP00000010866	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	LIF interleukin 6 family cytokine.	0.407
HGF	PIK3CA	ENSTGUP00000002672	ENSTGUP00000011093	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.588
IL6	APP	ENSTGUP00000002805	ENSTGUP00000029357	Interleukin 6.	Amyloid beta precursor protein.	0.407
IL6	BDNF	ENSTGUP00000002805	ENSTGUP00000022002	Interleukin 6.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.725