(42 nodes) Negative regulation of ion transmembrane transport network (Taeniopygia guttata)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	ARL6IP5	PRA1 family protein. (188 aa)
	FMR1	Fragile X mental retardation 1. (548 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (1284 aa)
	KCNAB1	Aldo_ket_red domain-containing protein. (544 aa)
	SLC30A1	Solute carrier family 30 member 1. (655 aa)
	SESTD1	SEC14 and spectrin domain containing 1. (697 aa)
	SRI	Putative sorcin transcript variant 1. (323 aa)
	ENSTGUP00000030827	annotation not available (64 aa)
	KCNAB2	Aldo_ket_red domain-containing protein. (416 aa)
	KCNE2	Potassium voltage-gated channel Isk-related subfamily E member 2. (115 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	ENSTGUP00000024337	annotation not available (242 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	REM1	RRAD and GEM like GTPase 1. (291 aa)
	SLN	Sarcolipin. (31 aa)
	NEDD4	E3 ubiquitin-protein ligase. (1302 aa)
	CLIC2	Chloride intracellular channel 2. (247 aa)
	SLC26A5	STAS domain-containing protein. (740 aa)
	PKD2	Uncharacterized protein. (903 aa)
	COMMD1	COMM domain-containing protein. (191 aa)
	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1614 aa)
	CBARP	LOW QUALITY PROTEIN: voltage-dependent calcium channel beta subunit-associated regulatory protein. (772 aa)
	OXSR1	Oxidative stress responsive kinase 1. (551 aa)
	RRAD	RRAD, Ras related glycolysis inhibitor and calcium channel regulator. (296 aa)
	PCSK9	Peptidase_S8 domain-containing protein; Belongs to the peptidase S8 family. (663 aa)
	STK39	Serine/threonine kinase 39. (495 aa)
	GNB5	WD_REPEATS_REGION domain-containing protein. (394 aa)
	ANO9	Anoctamin. (774 aa)
	SLC43A2	Uncharacterized protein. (564 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (163 aa)
	LOC100227551	Uncharacterized protein. (186 aa)
	MMP9	Matrix metallopeptidase 9. (723 aa)
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (101 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (493 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (407 aa)
	KEL	Uncharacterized protein. (718 aa)
	GOPC	PDZ domain-containing protein. (631 aa)
	GEM	GTP binding protein overexpressed in skeletal muscle. (297 aa)
	HECW2	Uncharacterized protein. (1562 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ENSTGUP00000038594	Translation initiation factor IF-2-like isoform X1. (746 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASQ2	PLN	ENSTGUP00000013787	ENSTGUP00000025695	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.520
CAV1	CAV3	ENSTGUP00000027745	ENSTGUP00000010724	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV1	ENSTGUP00000024337	ENSTGUP00000027745	ENSTGUP00000024337	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	annotation not available	0.511
CAV3	CAV1	ENSTGUP00000010724	ENSTGUP00000027745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV3	ENSTGUP00000024337	ENSTGUP00000010724	ENSTGUP00000024337	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	annotation not available	0.407
CAV3	REM1	ENSTGUP00000010724	ENSTGUP00000022824	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	RRAD and GEM like GTPase 1.	0.445
DRD3	DRD4	ENSTGUP00000013801	ENSTGUP00000022980	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.718
DRD3	GNB5	ENSTGUP00000013801	ENSTGUP00000006972	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	WD_REPEATS_REGION domain-containing protein.	0.509
DRD4	DRD3	ENSTGUP00000022980	ENSTGUP00000013801	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.718
DRD4	GNB5	ENSTGUP00000022980	ENSTGUP00000006972	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	WD_REPEATS_REGION domain-containing protein.	0.495
ENSTGUP00000024337	CAV1	ENSTGUP00000024337	ENSTGUP00000027745	annotation not available	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.511
ENSTGUP00000024337	CAV3	ENSTGUP00000024337	ENSTGUP00000010724	annotation not available	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.407
GNB5	DRD3	ENSTGUP00000006972	ENSTGUP00000013801	WD_REPEATS_REGION domain-containing protein.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.509
GNB5	DRD4	ENSTGUP00000006972	ENSTGUP00000022980	WD_REPEATS_REGION domain-containing protein.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.495
KCNE2	KCNE3	ENSTGUP00000029156	ENSTGUP00000013854	Potassium voltage-gated channel Isk-related subfamily E member 2.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.635
KCNE2	KCNE4	ENSTGUP00000029156	ENSTGUP00000020116	Potassium voltage-gated channel Isk-related subfamily E member 2.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.560
KCNE3	KCNE2	ENSTGUP00000013854	ENSTGUP00000029156	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Potassium voltage-gated channel Isk-related subfamily E member 2.	0.635
KCNE3	KCNE4	ENSTGUP00000013854	ENSTGUP00000020116	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.577
KCNE3	LOC100227551	ENSTGUP00000013854	ENSTGUP00000019394	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Uncharacterized protein.	0.560
KCNE4	KCNE2	ENSTGUP00000020116	ENSTGUP00000029156	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Potassium voltage-gated channel Isk-related subfamily E member 2.	0.560