(57 nodes) Organ growth network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SAV1	Salvador family WW domain containing protein 1. (379 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (425 aa)
	ANXA6	Annexin. (665 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	HLX	H2.0 like homeobox. (425 aa)
	AR	Androgen receptor. (684 aa)
	LOC100231082	Uncharacterized protein. (873 aa)
	SOX9	SRY-box transcription factor 9. (474 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
	LOC100224677	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (559 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (382 aa)
	ADRA1A	Adrenoceptor alpha 1A. (464 aa)
	BNC2	Basonuclin 2. (1020 aa)
	CER1	Cerberus 1, DAN family BMP antagonist. (273 aa)
	ANXA2	Annexin. (345 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4. (483 aa)
	ARID2	Uncharacterized protein. (1798 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (660 aa)
	CYP19A1	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (509 aa)
	ARX	Aristaless related homeobox. (567 aa)
	DIPK2A	Divergent protein kinase domain 2A. (429 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (727 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	EVC	EvC ciliary complex subunit 1. (906 aa)
	LEPR	Uncharacterized protein. (1135 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa)
	IFT80	Intraflagellar transport 80. (267 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (621 aa)
	IL7	Uncharacterized protein. (179 aa)
	THBS3	Thrombospondin 3. (956 aa)
	LOC101234126	Uncharacterized protein. (140 aa)
	OSTN	Uncharacterized protein. (144 aa)
	FXN	Frataxin. (235 aa)
	LOC115490537	Leptin receptor-like. (1122 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	ENSTGUP00000020883	Homeobox protein aristaless-related. (294 aa)
	TMEM38B	Transmembrane protein 38B. (343 aa)
	SDC3	Syndecan 3. (428 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (469 aa)
	NPPC	C-type natriuretic peptide. (120 aa)
	PDLIM5	PDZ and LIM domain 5. (711 aa)
	PLAG1	PLAG1 zinc finger. (501 aa)
	TENM4	Teneurin transmembrane protein 4. (2719 aa)
	ENSTGUP00000026997	annotation not available (687 aa)
	LOC100231082-2	Discoidin domain-containing receptor 2-like. (873 aa)
	LEP	Taeniopygia guttata leptin (LEP), mRNA. (168 aa)
	GJE1	Gap junction protein epsilon 1. (205 aa)
	STC1	Stanniocalcin 1. (247 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (433 aa)
	NKX2-5	Homeobox domain-containing protein. (329 aa)
	AKAP13	Uncharacterized protein. (2692 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (1179 aa)
	IER3IP1	Immediate early response 3-interacting protein 1 precursor. (91 aa)
	MMP13	Matrix metallopeptidase 13. (560 aa)
	ENSTGUP00000033975	annotation not available (497 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (383 aa)
	ECM1	Extracellular matrix protein 1. (419 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA2	ANXA6	ENSTGUP00000005515	ENSTGUP00000000831	Annexin.	Annexin.	0.657
ANXA6	ANXA2	ENSTGUP00000000831	ENSTGUP00000005515	Annexin.	Annexin.	0.657
AR	CYP19A1	ENSTGUP00000002859	ENSTGUP00000007225	Androgen receptor.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.731
AR	ESR1	ENSTGUP00000002859	ENSTGUP00000011604	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.728
AR	LEP	ENSTGUP00000002859	ENSTGUP00000028222	Androgen receptor.	Taeniopygia guttata leptin (LEP), mRNA.	0.550
CYP19A1	AR	ENSTGUP00000007225	ENSTGUP00000002859	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Androgen receptor.	0.731
CYP19A1	ESR1	ENSTGUP00000007225	ENSTGUP00000011604	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.796
CYP19A1	SOX9	ENSTGUP00000007225	ENSTGUP00000002966	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	SRY-box transcription factor 9.	0.528
ESR1	AR	ENSTGUP00000011604	ENSTGUP00000002859	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Androgen receptor.	0.728
ESR1	CYP19A1	ENSTGUP00000011604	ENSTGUP00000007225	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.796
ESR1	LEP	ENSTGUP00000011604	ENSTGUP00000028222	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Taeniopygia guttata leptin (LEP), mRNA.	0.559
ESR1	UBE3A	ENSTGUP00000011604	ENSTGUP00000010629	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.678
FGF7	FGF8	ENSTGUP00000019495	ENSTGUP00000010279	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.467
FGF7	SHH	ENSTGUP00000019495	ENSTGUP00000000707	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.623
FGF8	FGF7	ENSTGUP00000010279	ENSTGUP00000019495	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.467
FGF8	SHH	ENSTGUP00000010279	ENSTGUP00000000707	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.817
FGF8	SOX9	ENSTGUP00000010279	ENSTGUP00000002966	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.420
LEP	AR	ENSTGUP00000028222	ENSTGUP00000002859	Taeniopygia guttata leptin (LEP), mRNA.	Androgen receptor.	0.550
LEP	ESR1	ENSTGUP00000028222	ENSTGUP00000011604	Taeniopygia guttata leptin (LEP), mRNA.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.559
LEP	LEPR	ENSTGUP00000028222	ENSTGUP00000010376	Taeniopygia guttata leptin (LEP), mRNA.	Uncharacterized protein.	0.683