(93 nodes) Regulation of cysteine-type endopeptidase activity involved in apoptotic process network (Taeniopygia guttata)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (363 aa)
	LOC100223311	Uncharacterized protein. (742 aa)
	CRYAB	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (174 aa)
	LCK	Protein kinase domain-containing protein. (513 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
	TNFSF15	TNF superfamily member 15. (239 aa)
	SIRT1	Sirtuin 1. (750 aa)
	GRAMD4	GRAM domain containing 4. (641 aa)
	VIL1	Villin 1. (839 aa)
	F3	Coagulation factor III, tissue factor. (402 aa)
	PAK2	Non-specific serine/threonine protein kinase. (525 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (140 aa)
	SH3RF1	SH3 domain containing ring finger 1. (873 aa)
	DIABLO	Uncharacterized protein. (236 aa)
	CARD9	CARD domain-containing protein. (206 aa)
	NLE1	Notchless homolog 1. (509 aa)
	INTS1	Integrator complex subunit 1. (2109 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	DHCR24	24-dehydrocholesterol reductase. (525 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (447 aa)
	LOC100228004	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1381 aa)
	ARL6IP5	PRA1 family protein. (188 aa)
	PIDD1	P53-induced death domain protein 1. (894 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (367 aa)
	LOC100223333	Caspase 8. (459 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (475 aa)
	HSPD1	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (573 aa)
	LOC100229685	Uncharacterized protein. (183 aa)
	TNFSF10	TNF superfamily member 10; Belongs to the tumor necrosis factor family. (424 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1087 aa)
	THBS1	Uncharacterized protein. (1173 aa)
	CASP8AP2	Uncharacterized protein. (2002 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
	BIRC2	Uncharacterized protein. (598 aa)
	CASP2	Uncharacterized protein; Belongs to the peptidase C14A family. (426 aa)
	SOX7	Uncharacterized protein. (374 aa)
	HTRA2	HtrA serine peptidase 2. (510 aa)
	BAX	BCL2 associated X, apoptosis regulator. (225 aa)
	USP47	USP domain-containing protein; Belongs to the peptidase C19 family. (1447 aa)
	LOC115491390	Nuclear receptor subfamily 4 group A member 1. (574 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (420 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (280 aa)
	MMP9	Matrix metallopeptidase 9. (723 aa)
	ACER2	Alkaline ceramidase 2. (184 aa)
	PRR7	Proline rich 7, synaptic. (184 aa)
	ENSTGUP00000020595	annotation not available (95 aa)
	LOC105759524	Uncharacterized protein. (389 aa)
	RNF34	Ring finger protein 34. (388 aa)
	DELE1	Uncharacterized protein. (643 aa)
	HIP1R	Uncharacterized protein. (1047 aa)
	FAS	Uncharacterized protein. (363 aa)
	TNFAIP8	TNF alpha induced protein 8. (198 aa)
	CAAP1	Caspase activity and apoptosis inhibitor 1. (199 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (484 aa)
	FAM162A	Protein FAM162A. (173 aa)
	LOC105760451	CASPASE_P20 domain-containing protein. (760 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (702 aa)
	IFT57	Ig-like domain-containing protein. (657 aa)
	ENSTGUP00000023270	annotation not available (573 aa)
	REST	RE1 silencing transcription factor. (893 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (128 aa)
	ENSTGUP00000024522	annotation not available (197 aa)
	NLRP3	NACHT domain-containing protein. (901 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (273 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (248 aa)
	DAP	Putative death-associated protein 1 variant 1. (165 aa)
	FABP1	FABP domain-containing protein. (184 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (189 aa)
	ENSTGUP00000030303	annotation not available (363 aa)
	CASP8	Caspase 8. (480 aa)
	TFAP4	Transcription factor AP-4. (385 aa)
	ENSTGUP00000031299	annotation not available (304 aa)
	PIH1D1	LOW QUALITY PROTEIN: PIH1 domain-containing protein 1. (346 aa)
	XIAP	X-linked inhibitor of apoptosis. (495 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (426 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (78 aa)
	MGMT	Methyltransf_1N domain-containing protein. (201 aa)
	MALT1	MALT1 paracaspase. (878 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	PDCD5	Uncharacterized protein. (126 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1019 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (396 aa)
	ENSTGUP00000034670	annotation not available (523 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (405 aa)
	LOC100231563	Nuclear receptor subfamily 4 group A member 1. (574 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (190 aa)
	ENSTGUP00000035767	annotation not available (1415 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (395 aa)
	CCN1	Cellular communication network factor 1. (412 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16. (475 aa)
	RFFL	RING-type domain-containing protein. (396 aa)
	GAS6	Growth arrest specific 6. (704 aa)
	AIFM1	Uncharacterized protein. (593 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	APAF1	ENSTGUP00000037952	ENSTGUP00000009081	Uncharacterized protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.515
AIFM1	CASP9	ENSTGUP00000037952	ENSTGUP00000017449	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.559
AIFM1	DIABLO	ENSTGUP00000037952	ENSTGUP00000006354	Uncharacterized protein.	Uncharacterized protein.	0.558
APAF1	AIFM1	ENSTGUP00000009081	ENSTGUP00000037952	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.515
APAF1	BAX	ENSTGUP00000009081	ENSTGUP00000015983	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.760
APAF1	BCL2L11	ENSTGUP00000009081	ENSTGUP00000029207	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11 isoform X1.	0.552
APAF1	BIRC2	ENSTGUP00000009081	ENSTGUP00000013125	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.737
APAF1	BIRC5	ENSTGUP00000009081	ENSTGUP00000006056	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 5.	0.719
APAF1	BIRC7	ENSTGUP00000009081	ENSTGUP00000032040	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.737
APAF1	CASP10	ENSTGUP00000009081	ENSTGUP00000010628	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.848
APAF1	CASP2	ENSTGUP00000009081	ENSTGUP00000013612	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.884
APAF1	CASP8	ENSTGUP00000009081	ENSTGUP00000030393	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8.	0.884
APAF1	CASP9	ENSTGUP00000009081	ENSTGUP00000017449	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSTGUP00000009081	ENSTGUP00000022413	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.818
APAF1	DHCR24	ENSTGUP00000009081	ENSTGUP00000009790	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	24-dehydrocholesterol reductase.	0.418
APAF1	DIABLO	ENSTGUP00000009081	ENSTGUP00000006354	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.941
APAF1	ENSTGUP00000035767	ENSTGUP00000009081	ENSTGUP00000035767	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	annotation not available	0.416
APAF1	FASLG	ENSTGUP00000009081	ENSTGUP00000017541	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas ligand; Belongs to the tumor necrosis factor family.	0.611
APAF1	LOC100223333	ENSTGUP00000009081	ENSTGUP00000010625	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8.	0.891
APAF1	LOC100228004	ENSTGUP00000009081	ENSTGUP00000010040	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uveal autoantigen with coiled-coil domains and ankyrin repeats.	0.416