STRINGSTRING
LOC115491405 LOC115491405 LOC100224755 LOC100224755 SASH1 SASH1 CD34 CD34 ENSTGUP00000023034 ENSTGUP00000023034 TIE1 TIE1 VEGFD VEGFD MINAR1 MINAR1 THBS2 THBS2 DLL1 DLL1 ANGPTL3 ANGPTL3 CTSH CTSH ROCK1 ROCK1 HRG HRG MDK MDK CREB3L1 CREB3L1 SULF1 SULF1 THBS1 THBS1 FLT1 FLT1 SPRED1 SPRED1 ENSTGUP00000012356 ENSTGUP00000012356 TBC1D31 TBC1D31 CNMD CNMD AGO2 AGO2 ANGPT2 ANGPT2 ROCK2 ROCK2 EPHA1 EPHA1 LOC100223710 LOC100223710 RECK RECK C5 C5 VEGFC VEGFC LOC100228395 LOC100228395 CD40 CD40 SERPINF1 SERPINF1 LOC100229347 LOC100229347 F3 F3 BMPER BMPER CTNNB1 CTNNB1 TSPAN12 TSPAN12 APOH APOH AGGF1 AGGF1 SEMA4A SEMA4A NAXE NAXE TGFBR2 TGFBR2 ENG ENG SIRT1 SIRT1 IL1B IL1B LOC100230282 LOC100230282 ITGB3 ITGB3 HOXA5 HOXA5 BRCA1 BRCA1 RAMP2 RAMP2 SMAD1 SMAD1 ITGB8 ITGB8 SEMA3E SEMA3E GAB1 GAB1 TNMD TNMD EPHA2 EPHA2 CCBE1 CCBE1 LOC100222345 LOC100222345 KRIT1 KRIT1 SARS1 SARS1 TEK TEK IL10 IL10 SIRT6 SIRT6 E2F2 E2F2 MYDGF MYDGF TBXA2R TBXA2R FGF1 FGF1 TLR3 TLR3 FGF18 FGF18 HTATIP2 HTATIP2 FASLG FASLG VASH2 VASH2 ENSTGUP00000023270 ENSTGUP00000023270 LOC105759334 LOC105759334 NFE2L2 NFE2L2 ECM1 ECM1 XBP1 XBP1 JCAD JCAD BTG1 BTG1 ENPP2 ENPP2 ENSTGUP00000034670 ENSTGUP00000034670 JMJD8 JMJD8 FKBPL FKBPL ENSTGUP00000033742 ENSTGUP00000033742 AQP1 AQP1 GATA2 GATA2 EFNA3 EFNA3 WARS1 WARS1 APELA APELA APLNR APLNR ENSTGUP00000031243 ENSTGUP00000031243 ENSTGUP00000031226 ENSTGUP00000031226 LOC100226329-2 LOC100226329-2 TGFB2 TGFB2 DDAH1 DDAH1 LOC100221863 LOC100221863 LOC100226329 LOC100226329 ATP2B4 ATP2B4 KDR KDR STIM1-2 STIM1-2 ADGRB2 ADGRB2 LOC115491504 LOC115491504 ZC3H12A ZC3H12A LEP LEP PLXND1 PLXND1 CYP1B1 CYP1B1 NINJ1 NINJ1 VASH1 VASH1 ECSCR ECSCR JUP JUP HGS HGS EFNA1 EFNA1 FGF2 FGF2 ENSTGUP00000024315 ENSTGUP00000024315 ENSTGUP00000024289 ENSTGUP00000024289 VEGFA VEGFA H0ZXJ2_TAEGU H0ZXJ2_TAEGU S100A1 S100A1 ABCC8 ABCC8 CCN6 CCN6 PGF PGF LOC115491349 LOC115491349 HMGA2 HMGA2 ADGRB3 ADGRB3 PIK3CD PIK3CD ADGRB1 ADGRB1 CLDN5 CLDN5 LOC100223591 LOC100223591 STIM1 STIM1 FOXO4 FOXO4 ETS1 ETS1 ENSTGUP00000021498 ENSTGUP00000021498 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC115491405Serine/threonine-protein kinase receptor R3 isoform X2. (493 aa)
LOC100224755Transcription factor Sp1-like. (764 aa)
SASH1SAM and SH3 domain containing 1. (1206 aa)
CD34Uncharacterized protein. (372 aa)
ENSTGUP00000023034annotation not available (327 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1124 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (920 aa)
THBS2Thrombospondin 2. (1259 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (727 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (459 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (367 aa)
ROCK1Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1358 aa)
HRGUncharacterized protein. (626 aa)
MDKMidkine. (139 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (505 aa)
SULF1Extracellular sulfatase. (1120 aa)
THBS1Uncharacterized protein. (1173 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1325 aa)
SPRED1Sprouty related EVH1 domain containing 1. (413 aa)
ENSTGUP00000012356annotation not available (130 aa)
TBC1D31TBC1 domain family member 31. (1046 aa)
CNMDChondromodulin. (344 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (864 aa)
ANGPT2Angiopoietin 2. (494 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
EPHA1EPH receptor A1. (962 aa)
LOC100223710Uncharacterized protein. (179 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (963 aa)
C5Uncharacterized protein. (1678 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (468 aa)
LOC100228395Uncharacterized protein. (502 aa)
CD40CD40 molecule. (280 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (416 aa)
LOC100229347Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1311 aa)
F3Coagulation factor III, tissue factor. (402 aa)
BMPERBMP binding endothelial regulator. (679 aa)
CTNNB1Catenin beta 1. (781 aa)
TSPAN12Tetraspanin. (305 aa)
APOHUncharacterized protein. (350 aa)
AGGF1Uncharacterized protein. (707 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (779 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (299 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
ENGEndoglin. (631 aa)
SIRT1Sirtuin 1. (750 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (299 aa)
LOC100230282Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (586 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (797 aa)
HOXA5Homeobox A5. (270 aa)
BRCA1Uncharacterized protein. (1803 aa)
RAMP2Receptor activity modifying protein 2. (181 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (786 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
GAB1GRB2 associated binding protein 1. (720 aa)
TNMDTenomodulin. (332 aa)
EPHA2EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
CCBE1Collagen and calcium binding EGF domains 1. (394 aa)
LOC100222345Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
KRIT1Uncharacterized protein. (736 aa)
SARS1Seryl-tRNA synthetase. (594 aa)
TEKTEK receptor tyrosine kinase. (1117 aa)
IL10Interleukin 10. (165 aa)
SIRT6Sirtuin 6. (348 aa)
E2F2E2F transcription factor 2. (450 aa)
MYDGFMyeloid derived growth factor. (298 aa)
TBXA2RThromboxane A2 receptor. (352 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HTATIP2HIV-1 Tat interactive protein 2. (224 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
VASH2Vasohibin 2. (367 aa)
ENSTGUP00000023270annotation not available (573 aa)
LOC105759334PDZ domain-containing protein. (188 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (623 aa)
ECM1Extracellular matrix protein 1. (419 aa)
XBP1X-box binding protein 1. (260 aa)
JCADJunctional cadherin 5 associated. (1330 aa)
BTG1BTG anti-proliferation factor 1. (180 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (910 aa)
ENSTGUP00000034670annotation not available (523 aa)
JMJD8Jumonji domain containing 8. (477 aa)
FKBPLFKBP prolyl isomerase like. (598 aa)
ENSTGUP00000033742annotation not available (1045 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
GATA2GATA binding protein 2. (466 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (348 aa)
WARS1WHEP-TRS domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (478 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
APLNRUncharacterized protein. (371 aa)
ENSTGUP00000031243annotation not available (686 aa)
ENSTGUP00000031226annotation not available (168 aa)
LOC100226329-2Glutamine synthetase. (387 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (433 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (369 aa)
LOC100221863Uncharacterized protein. (511 aa)
LOC100226329Glutamine synthetase. (387 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1338 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
STIM1-2Stromal interaction molecule 1 isoform X6. (422 aa)
ADGRB2G_PROTEIN_RECEP_F2_4 domain-containing protein. (1494 aa)
LOC115491504Cyclic nucleotide-binding domain-containing protein. (932 aa)
ZC3H12AC3H1-type domain-containing protein. (609 aa)
LEPTaeniopygia guttata leptin (LEP), mRNA. (168 aa)
PLXND1Plexin D1. (1929 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
NINJ1Ninjurin 1. (173 aa)
VASH1Vasohibin 1. (349 aa)
ECSCREndothelial cell-specific chemotaxis regulator isoform X1. (289 aa)
JUPJunction plakoglobin. (764 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (897 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (210 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
ENSTGUP00000024315annotation not available (176 aa)
ENSTGUP00000024289Basic proline-rich protein-like. (206 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
H0ZXJ2_TAEGUEMI domain-containing protein. (1063 aa)
S100A1Protein S100; Belongs to the S-100 family. (784 aa)
ABCC8ATP binding cassette subfamily C member 8. (1620 aa)
CCN6Cellular communication network factor 6. (187 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (255 aa)
LOC115491349Transcription factor Sp1. (764 aa)
HMGA2High mobility group protein HMGI-C isoform X1. (186 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1558 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1629 aa)
CLDN5Claudin-5. (216 aa)
LOC100223591EMILIN-1 isoform X1. (862 aa)
STIM1Stromal interaction molecule 1. (1283 aa)
FOXO4Forkhead box O4. (532 aa)
ETS1ETS proto-oncogene 1, transcription factor. (552 aa)
ENSTGUP00000021498annotation not available (382 aa)
PIK3CBUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
Server load: low (12%) [HD]