STRINGSTRING
PKD2 PKD2 ABRAXAS1 ABRAXAS1 GATA3 GATA3 MEIOC MEIOC NUDT6 NUDT6 RAD1 RAD1 MAD2L1 MAD2L1 INHBA INHBA CLSPN CLSPN LOC100218902 LOC100218902 H0YTF5_TAEGU H0YTF5_TAEGU PTTG1-2 PTTG1-2 INIP INIP CHEK1 CHEK1 GAS1 GAS1 RRP8 RRP8 UIMC1 UIMC1 BTG4 BTG4 DOT1L DOT1L ZW10 ZW10 CCDC84 CCDC84 BRCA1 BRCA1 RINT1 RINT1 DTL DTL RBL1 RBL1 CCNF CCNF BRINP1 BRINP1 SIRT1 SIRT1 TPR TPR DNA2 DNA2 LOC100224554 LOC100224554 MAPK12 MAPK12 NEK11 NEK11 TOPBP1 TOPBP1 CTNNB1 CTNNB1 ZNF207 ZNF207 TNKS TNKS CRLF3 CRLF3 ATRIP ATRIP CDK1 CDK1 CCND1 CCND1 MSH2 MSH2 MSH6 MSH6 MYOCD MYOCD ATRX ATRX TAOK1 TAOK1 KNTC1 KNTC1 PTPRK PTPRK TFAP4 TFAP4 CDK5 CDK5 MUC1 MUC1 H1A086_TAEGU H1A086_TAEGU EME1 EME1 FHL1 FHL1 KAT2A KAT2A HASPIN HASPIN MRNIP MRNIP NEK2 NEK2 MFSD11 MFSD11 RFWD3 RFWD3 CRADD CRADD HINFP HINFP PTTG1 PTTG1 JADE1 JADE1 NABP2 NABP2 CTDSPL CTDSPL BTG2 BTG2 BRINP3 BRINP3 FZR1 FZR1 ANGEL1 ANGEL1 ENSTGUP00000025305 ENSTGUP00000025305 CDKN1C CDKN1C PINX1 PINX1 SPDL1 SPDL1 ENSTGUP00000023855 ENSTGUP00000023855 NABP1 NABP1 LOC100230026 LOC100230026 ENSTGUP00000023270 ENSTGUP00000023270 CDKN2C CDKN2C GMNN GMNN CDC73 CDC73 BABAM2 BABAM2 GMNC GMNC PPP1R10 PPP1R10 H0YW59_TAEGU H0YW59_TAEGU CDC6 CDC6 HPGD HPGD ENSTGUP00000021519 ENSTGUP00000021519 FOXO4 FOXO4 ANGEL2 ANGEL2 TOM1L1 TOM1L1 TRIP13 TRIP13 FBXO31 FBXO31 WAPL WAPL CTDSP1 CTDSP1 FOXN3 FOXN3 SYF2 SYF2 SCRIB SCRIB MDM1 MDM1 MIIP MIIP APBB2 APBB2 LOC115492046 LOC115492046 NME6 NME6 RAD17 RAD17 BRINP2 BRINP2 EEF1AKNMT EEF1AKNMT INTS3 INTS3 CDK5RAP3 CDK5RAP3 LOC115491390 LOC115491390 USP47 USP47 E2F8 E2F8 LOC100230026-2 LOC100230026-2 FZD3 FZD3 CASP2 CASP2 RHNO1 RHNO1 GPR132 GPR132 MRE11 MRE11 CDKN1B CDKN1B ATM ATM TTK TTK MTBP MTBP RB1 RB1 FBXO43 FBXO43 TMEM67 TMEM67 NBN NBN EIF2AK4 EIF2AK4 BUB3 BUB3 CDK5RAP2 CDK5RAP2 LOC115490804 LOC115490804 CDK5RAP1 CDK5RAP1 PLK1 PLK1 ENSTGUP00000037836 ENSTGUP00000037836 CCP110 CCP110 TIMELESS TIMELESS MOS MOS H1A1E4_TAEGU H1A1E4_TAEGU ENSTGUP00000037304 ENSTGUP00000037304 LATS2 LATS2 NOP53 NOP53 DCUN1D3 DCUN1D3 CACNB4 CACNB4 TP53BP1 TP53BP1 C10orf90 C10orf90 BTG1 BTG1 LOC115493600 LOC115493600 GIGYF2 GIGYF2 LOC100231563 LOC100231563 ORC1 ORC1 KAT2B KAT2B SDE2 SDE2 BUB1B BUB1B USP28 USP28 ENSTGUP00000034670 ENSTGUP00000034670 PRPF19 PRPF19 ENSTGUP00000034033 ENSTGUP00000034033 TRIM37 TRIM37 LRRC1 LRRC1 MAP3K20 MAP3K20 ZNF830 ZNF830 RPS6KA2 RPS6KA2 NUBP1 NUBP1 BRCC3 BRCC3 XPC XPC ENSTGUP00000032655 ENSTGUP00000032655 RAD9A RAD9A SRSF3 SRSF3 PSMG2 PSMG2 AVEN AVEN WAC WAC PPP1R10-2 PPP1R10-2 HEXIM1 HEXIM1 MAD2L1BP MAD2L1BP ENSTGUP00000031407 ENSTGUP00000031407 LOC100222344 LOC100222344 ENSTGUP00000031587 ENSTGUP00000031587 TICRR TICRR PTPN3 PTPN3 MAD1L1 MAD1L1 CHFR CHFR ERCC6 ERCC6 ATR ATR PMS2 PMS2 TAOK3 TAOK3 TIPIN TIPIN ZWILCH ZWILCH LATS1 LATS1 MTRF1L MTRF1L HECA HECA FBXO7 FBXO7 TNFAIP3 TNFAIP3 PRKDC PRKDC EPM2A EPM2A ZFYVE19 ZFYVE19 LIF LIF KLHL22 KLHL22 PIDD1 PIDD1 RAD9B RAD9B FANCD2 FANCD2 CEP63 CEP63 HUS1 HUS1 NLE1 NLE1 BUB1 BUB1 TEX14 TEX14 RBL2 RBL2 E2F7 E2F7 CDT1 CDT1 CHEK2 CHEK2 SUSD2 SUSD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKD2Uncharacterized protein. (903 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (405 aa)
GATA3GATA binding protein 3. (443 aa)
MEIOCMeiosis specific with coiled-coil domain. (964 aa)
NUDT6Nudix hydrolase 6. (307 aa)
RAD1RAD1 checkpoint DNA exonuclease. (281 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (208 aa)
INHBAInhibin subunit beta A. (559 aa)
CLSPNUncharacterized protein. (1423 aa)
LOC100218902ANK_REP_REGION domain-containing protein. (294 aa)
H0YTF5_TAEGUANK_REP_REGION domain-containing protein. (133 aa)
PTTG1-2Securin. (266 aa)
INIPSOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity). (104 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
GAS1Uncharacterized protein. (159 aa)
RRP8Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (285 aa)
UIMC1Ubiquitin interaction motif containing 1. (813 aa)
BTG4BTG anti-proliferation factor 4. (229 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1723 aa)
ZW10Zw10 kinetochore protein. (782 aa)
CCDC84Coiled-coil domain containing 84. (450 aa)
BRCA1Uncharacterized protein. (1803 aa)
RINT1Uncharacterized protein. (638 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
RBL1RB transcriptional corepressor like 1. (977 aa)
CCNFCyclin F; Belongs to the cyclin family. (760 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (816 aa)
SIRT1Sirtuin 1. (750 aa)
TPRTPR_MLP1_2 domain-containing protein. (2313 aa)
DNA2Uncharacterized protein. (1021 aa)
LOC100224554Uncharacterized protein. (1418 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
NEK11NIMA related kinase 11. (597 aa)
TOPBP1Uncharacterized protein. (1520 aa)
CTNNB1Catenin beta 1. (781 aa)
ZNF207Zinc finger protein 207. (496 aa)
TNKSPoly [ADP-ribose] polymerase. (1266 aa)
CRLF3Cytokine receptor like factor 3. (442 aa)
ATRIPATR interacting protein. (798 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (936 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1262 aa)
MYOCDMyocardin. (875 aa)
ATRXATRX chromatin remodeler. (2439 aa)
TAOK1TAO kinase 1. (1000 aa)
KNTC1Kinetochore associated 1. (2111 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1490 aa)
TFAP4Transcription factor AP-4. (385 aa)
CDK5Cyclin-dependent-like kinase 5. (808 aa)
MUC1Uncharacterized protein. (397 aa)
H1A086_TAEGUHA2 domain-containing protein. (1046 aa)
EME1ERCC4 domain-containing protein. (545 aa)
FHL1Four and a half LIM domains 1. (324 aa)
KAT2ALysine acetyltransferase 2A. (833 aa)
HASPINSerine/threonine-protein kinase haspin. (891 aa)
MRNIPMRN complex-interacting protein. (357 aa)
NEK2NIMA related kinase 2. (497 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
RFWD3Ring finger and WD repeat domain 3. (750 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (248 aa)
HINFPHistone H4 transcription factor. (603 aa)
PTTG1Uncharacterized protein. (448 aa)
JADE1Uncharacterized protein. (859 aa)
NABP2SOSS complex subunit B1. (320 aa)
CTDSPLFCP1 homology domain-containing protein. (338 aa)
BTG2Protein Tob/BTG. (172 aa)
BRINP3BMP/retinoic acid inducible neural specific 3. (860 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
ANGEL1Angel homolog 1. (674 aa)
ENSTGUP00000025305annotation not available (534 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C isoform X1. (181 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (359 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (624 aa)
ENSTGUP00000023855annotation not available (1612 aa)
NABP1Nucleic acid binding protein 1. (207 aa)
LOC100230026Uncharacterized protein. (1326 aa)
ENSTGUP00000023270annotation not available (573 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (167 aa)
GMNNGeminin DNA replication inhibitor. (228 aa)
CDC73Cell division cycle 73. (531 aa)
BABAM2BRISC and BRCA1 A complex member 2. (493 aa)
GMNCGeminin coiled-coil domain containing. (305 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (866 aa)
H0YW59_TAEGUUncharacterized protein. (246 aa)
CDC6Cell division cycle 6. (558 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
ENSTGUP00000021519annotation not available (333 aa)
FOXO4Forkhead box O4. (532 aa)
ANGEL2Angel homolog 2. (672 aa)
TOM1L1Target of myb1 like 1 membrane trafficking protein. (503 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (453 aa)
FBXO31F-box protein 31. (568 aa)
WAPLWAPL cohesin release factor. (1434 aa)
CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (258 aa)
FOXN3Forkhead box N3. (497 aa)
SYF2Pre-mRNA-splicing factor SYF2. (320 aa)
SCRIBScribble planar cell polarity protein. (1623 aa)
MDM1Uncharacterized protein. (756 aa)
MIIPUncharacterized protein. (467 aa)
APBB2Uncharacterized protein. (762 aa)
LOC115492046RNA-binding protein 14-like. (685 aa)
NME6Nucleoside diphosphate kinase. (262 aa)
RAD17RAD17 checkpoint clamp loader component. (944 aa)
BRINP2BMP/retinoic acid inducible neural specific 2. (788 aa)
EEF1AKNMTEEF1A lysine and N-terminal methyltransferase. (658 aa)
INTS3Integrator complex subunit 3. (1022 aa)
CDK5RAP3Uncharacterized protein. (477 aa)
LOC115491390Nuclear receptor subfamily 4 group A member 1. (574 aa)
USP47USP domain-containing protein; Belongs to the peptidase C19 family. (1447 aa)
E2F8E2F transcription factor 8. (896 aa)
LOC100230026-2HA2 domain-containing protein. (1245 aa)
FZD3Frizzled domain-containing protein. (696 aa)
CASP2Uncharacterized protein; Belongs to the peptidase C14A family. (426 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (269 aa)
GPR132G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (716 aa)
CDKN1BPutative cyclin-dependent kinase inhibitor 1B. (198 aa)
ATMNon-specific serine/threonine protein kinase. (2226 aa)
TTKProtein kinase domain-containing protein. (863 aa)
MTBPMDM2 binding protein. (1041 aa)
RB1RB transcriptional corepressor 1. (931 aa)
FBXO43F-box protein 43. (670 aa)
TMEM67Transmembrane protein 67. (983 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (756 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1655 aa)
BUB3BUB3 mitotic checkpoint protein. (329 aa)
CDK5RAP2Cnn_1N domain-containing protein. (2275 aa)
LOC115490804BRISC and BRCA1-A complex member 1-like. (434 aa)
CDK5RAP1CDK5 regulatory subunit associated protein 1. (566 aa)
PLK1Polo like kinase 1. (933 aa)
ENSTGUP00000037836annotation not available (119 aa)
CCP110Centriolar coiled-coil protein 110. (1026 aa)
TIMELESSProtein timeless homolog isoform X1. (1338 aa)
MOSProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (349 aa)
H1A1E4_TAEGUPID domain-containing protein. (624 aa)
ENSTGUP00000037304annotation not available (89 aa)
LATS2Non-specific serine/threonine protein kinase. (1153 aa)
NOP53Ribosome biogenesis protein NOP53-like. (461 aa)
DCUN1D3DCN1-like protein. (304 aa)
CACNB4SH3 domain-containing protein. (478 aa)
TP53BP1Tumor protein p53 binding protein 1. (1923 aa)
C10orf90ALMS_motif domain-containing protein. (728 aa)
BTG1BTG anti-proliferation factor 1. (180 aa)
LOC115493600Uncharacterized protein. (849 aa)
GIGYF2GYF domain-containing protein. (1277 aa)
LOC100231563Nuclear receptor subfamily 4 group A member 1. (574 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (902 aa)
KAT2BLysine acetyltransferase 2B. (810 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
BUB1BUncharacterized protein. (1065 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1135 aa)
ENSTGUP00000034670annotation not available (523 aa)
PRPF19Pre-mRNA processing factor 19. (635 aa)
ENSTGUP00000034033annotation not available (1338 aa)
TRIM37Uncharacterized protein. (1068 aa)
LRRC1Leucine rich repeat containing 1. (795 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (476 aa)
ZNF830Zinc finger protein 830. (431 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (769 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (666 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (261 aa)
XPCUncharacterized protein. (865 aa)
ENSTGUP00000032655annotation not available (422 aa)
RAD9ACell cycle checkpoint control protein RAD9A. (387 aa)
SRSF3Uncharacterized protein. (242 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (344 aa)
AVENApoptosis and caspase activation inhibitor. (353 aa)
WACWW domain containing adaptor with coiled-coil. (645 aa)
PPP1R10-2Serine/threonine-protein phosphatase 1 regulatory subunit 10. (898 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (289 aa)
MAD2L1BPMAD2L1 binding protein. (381 aa)
ENSTGUP00000031407annotation not available (277 aa)
LOC100222344Uncharacterized protein. (309 aa)
ENSTGUP00000031587annotation not available (323 aa)
TICRRTreslin_N domain-containing protein. (1957 aa)
PTPN3Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (975 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (723 aa)
CHFRCheckpoint with forkhead and ring finger domains. (715 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1614 aa)
ATRUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2658 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (870 aa)
TAOK3TAO kinase 3. (908 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (536 aa)
ZWILCHZwilch kinetochore protein. (595 aa)
LATS1Large tumor suppressor kinase 1. (1138 aa)
MTRF1LF-box protein 5. (592 aa)
HECAHdc homolog, cell cycle regulator. (128 aa)
FBXO7F-box protein 7. (527 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
PRKDCUncharacterized protein; Belongs to the PI3/PI4-kinase family. (4133 aa)
EPM2AEPM2A glucan phosphatase, laforin. (319 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (422 aa)
LIFLIF interleukin 6 family cytokine. (211 aa)
KLHL22BTB domain-containing protein. (638 aa)
PIDD1P53-induced death domain protein 1. (894 aa)
RAD9BRAD9 checkpoint clamp component B. (417 aa)
FANCD2FA complementation group D2. (1445 aa)
CEP63Centrosomal protein 63. (709 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
NLE1Notchless homolog 1. (509 aa)
BUB1Uncharacterized protein. (1092 aa)
TEX14Uncharacterized protein. (1462 aa)
RBL2RB transcriptional corepressor like 2. (1126 aa)
E2F7E2F transcription factor 7. (900 aa)
CDT1Chromatin licensing and DNA replication factor 1. (597 aa)
CHEK2Checkpoint kinase 2. (532 aa)
SUSD2Uncharacterized protein. (834 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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