STRINGSTRING
WNT3 WNT3 DRD2 DRD2 GHRHR GHRHR ENSTGUP00000000650 ENSTGUP00000000650 ALDOB ALDOB CITED4 CITED4 PAM PAM PTF1A PTF1A ELF3 ELF3 SLC46A2 SLC46A2 IRF6-2 IRF6-2 AREG AREG H0YUE5_TAEGU H0YUE5_TAEGU EPHA2 EPHA2 GATA3 GATA3 PKD2 PKD2 HGF HGF EDNRA EDNRA EDA EDA HLX HLX IL6 IL6 AR AR MSN MSN SOX9 SOX9 HOXA5 HOXA5 HOXA10 HOXA10 ETV4 ETV4 PROX1 PROX1 CCDC40 CCDC40 HOXB9 HOXB9 STRA6 STRA6 PITX2 PITX2 SRF SRF RPGRIP1L RPGRIP1L CTNNB1 CTNNB1 GHRH GHRH MST1 MST1 DAG1 DAG1 GPAT4 GPAT4 DDX55 DDX55 RXFP1 RXFP1 SERPINF1 SERPINF1 GCM2 GCM2 EDN1 EDN1 CCNB2 CCNB2 FOXN1 FOXN1 ATP7A ATP7A PCSK1 PCSK1 FA2H FA2H LHX3 LHX3 TGFBR1 TGFBR1 CYP19A1 CYP19A1 NR0B1 NR0B1 HESX1 HESX1 E2F7 E2F7 SLC7A5 SLC7A5 APRT APRT TBX2 TBX2 CUL3 CUL3 PTPN3 PTPN3 MAD1L1 MAD1L1 PCK1 PCK1 HNF1B HNF1B SP3 SP3 CIT CIT NKX2-3 NKX2-3 PCSK9 PCSK9 EDAR EDAR HNF1A HNF1A FGF8 FGF8 LOC100225657 LOC100225657 UBE3A UBE3A SMARCB1 SMARCB1 ACADM ACADM MDK MDK PIK3CA PIK3CA VIP VIP LOC100224870 LOC100224870 CYP7B1 CYP7B1 ESR1 ESR1 FRZB FRZB LATS1 LATS1 GSX1 GSX1 PDX1 PDX1 C6orf58 C6orf58 SRP54 SRP54 ATP7B ATP7B SEC63 SEC63 LOC115493455 LOC115493455 CPB2 CPB2 ATM ATM BCL11B BCL11B TYR TYR ZBTB1 ZBTB1 ID2 ID2 ARF6 ARF6 H0ZTH0_TAEGU H0ZTH0_TAEGU WNT11 WNT11 LOC100222335 LOC100222335 BAX BAX STAT6 STAT6 E2F8 E2F8 LOC100229817 LOC100229817 BTRC BTRC CDK5RAP3 CDK5RAP3 ENSTGUP00000017345 ENSTGUP00000017345 ASH1L ASH1L ENSTGUP00000018275 ENSTGUP00000018275 ACER1 ACER1 HOXD13 HOXD13 PYGO2 PYGO2 SCRIB SCRIB FGF7 FGF7 WT1 WT1 ARHGAP5 ARHGAP5 MSANTD4 MSANTD4 ENSTGUP00000020434 ENSTGUP00000020434 SEMA3C SEMA3C CTC1 CTC1 GFER GFER CREB1 CREB1 ENSTGUP00000022263 ENSTGUP00000022263 CSF1 CSF1 APOA1 APOA1 ENSTGUP00000022493 ENSTGUP00000022493 TP63 TP63 PKD1 PKD1 ZMPSTE24 ZMPSTE24 ENSTGUP00000023270 ENSTGUP00000023270 TAF10 TAF10 LOC100225382 LOC100225382 NRG3 NRG3 OTP OTP ENSTGUP00000023855 ENSTGUP00000023855 ENSTGUP00000024315 ENSTGUP00000024315 COBL COBL LOC100225657-2 LOC100225657-2 LOC100232675 LOC100232675 ENSTGUP00000025007 ENSTGUP00000025007 LHX4 LHX4 TNFSF11 TNFSF11 PLAG1 PLAG1 NR3C2 NR3C2 LRP5 LRP5 ENSTGUP00000026483 ENSTGUP00000026483 ENSTGUP00000027106 ENSTGUP00000027106 SLC29A1 SLC29A1 TNFRSF11A TNFRSF11A CYP1B1 CYP1B1 PSEN1 PSEN1 CAV1 CAV1 ZDHHC21 ZDHHC21 MED1 MED1 PLXND1 PLXND1 CRKL CRKL RB1CC1 RB1CC1 DNAAF1 DNAAF1 ENSTGUP00000028466 ENSTGUP00000028466 BCL2L11 BCL2L11 H0YQU3_TAEGU H0YQU3_TAEGU CEBPB CEBPB UPF2 UPF2 ENSTGUP00000029939 ENSTGUP00000029939 TGFB3 TGFB3 TGFB2 TGFB2 NKX2-5 NKX2-5 ZNF330 ZNF330 ID1 ID1 GLI1 GLI1 FGL1 FGL1 TBX3 TBX3 LEF1 LEF1 CEBPB-2 CEBPB-2 GDF7 GDF7 SMAD4 SMAD4 TCF21 TCF21 ENSTGUP00000033710 ENSTGUP00000033710 LRRC1 LRRC1 ENSTGUP00000034670 ENSTGUP00000034670 FADD FADD LOC115498196 LOC115498196 XBP1 XBP1 CACNB4 CACNB4 CLDN1 CLDN1 H0Z6I1_TAEGU H0Z6I1_TAEGU FRS2 FRS2 CEBPG CEBPG LOC100218892 LOC100218892 ALDH1A3 ALDH1A3 IGFBP5 IGFBP5 NEURL1 NEURL1 HOXD3 HOXD3 LOC115492668 LOC115492668 ANXA1 ANXA1 ESRP2 ESRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (473 aa)
GHRHRUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (425 aa)
ENSTGUP00000000650annotation not available (226 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (204 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (914 aa)
PTF1APancreas associated transcription factor 1a. (274 aa)
ELF3E74 like ETS transcription factor 3. (368 aa)
SLC46A2Solute carrier family 46 member 2. (452 aa)
IRF6-2Interferon regulatory factor 6. (460 aa)
AREGAmphiregulin. (195 aa)
H0YUE5_TAEGUMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (590 aa)
EPHA2EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
GATA3GATA binding protein 3. (443 aa)
PKD2Uncharacterized protein. (903 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (239 aa)
HLXH2.0 like homeobox. (425 aa)
IL6Interleukin 6. (221 aa)
ARAndrogen receptor. (684 aa)
MSNMoesin. (580 aa)
SOX9SRY-box transcription factor 9. (474 aa)
HOXA5Homeobox A5. (270 aa)
HOXA10Homeobox A10. (364 aa)
ETV4ETS variant 4. (453 aa)
PROX1Prospero homeobox 1. (738 aa)
CCDC40Coiled-coil domain containing 40. (951 aa)
HOXB9Homeobox B9. (207 aa)
STRA6Uncharacterized protein. (560 aa)
PITX2Homeobox protein. (360 aa)
SRFSerum response factor. (485 aa)
RPGRIP1LC2-C2_1 domain-containing protein. (796 aa)
CTNNB1Catenin beta 1. (781 aa)
GHRHGrowth hormone releasing hormone. (154 aa)
MST1Macrophage stimulating 1. (705 aa)
DAG1Dystroglycan 1. (896 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (451 aa)
DDX55RNA helicase. (596 aa)
RXFP1Relaxin family peptide receptor 1. (766 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (416 aa)
GCM2Glial cells missing transcription factor 2. (445 aa)
EDN1Endothelin 1. (202 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (401 aa)
FOXN1Fork-head domain-containing protein. (590 aa)
ATP7AATPase copper transporting alpha. (1497 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (401 aa)
LHX3LIM homeobox 3. (378 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
CYP19A1Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (509 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (265 aa)
HESX1HESX homeobox 1. (195 aa)
E2F7E2F transcription factor 7. (900 aa)
SLC7A5Solute carrier family 7 member 5. (522 aa)
APRTAdenine phosphoribosyltransferase. (177 aa)
TBX2TBX domain-containing protein. (653 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
PTPN3Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (975 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (723 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
HNF1BHNF1 homeobox B. (531 aa)
SP3Sp3 transcription factor. (773 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2076 aa)
NKX2-3NK2 homeobox 3. (327 aa)
PCSK9Peptidase_S8 domain-containing protein; Belongs to the peptidase S8 family. (663 aa)
EDAREctodysplasin A receptor. (463 aa)
HNF1AHNF1 homeobox A. (628 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
LOC100225657Wnt ligand secretion mediator. (541 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (386 aa)
ACADMGeranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (730 aa)
MDKMidkine. (139 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VIPVasoactive intestinal peptide. (215 aa)
LOC100224870Uncharacterized protein. (557 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (621 aa)
FRZBFrizzled related protein. (379 aa)
LATS1Large tumor suppressor kinase 1. (1138 aa)
GSX1GS homeobox 1. (245 aa)
PDX1Homeobox domain-containing protein. (260 aa)
C6orf58Chromosome 6 open reading frame 58. (364 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (477 aa)
ATP7BUncharacterized protein. (1530 aa)
SEC63SEC63 homolog, protein translocation regulator. (755 aa)
LOC115493455a_DG1_N2 domain-containing protein. (579 aa)
CPB2Carboxypeptidase B2. (424 aa)
ATMNon-specific serine/threonine protein kinase. (2226 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (883 aa)
TYRTyrosinase. (537 aa)
ZBTB1Zinc finger and BTB domain containing 1. (711 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (142 aa)
H0ZTH0_TAEGUUncharacterized protein. (959 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
LOC100222335EGF-like domain-containing protein. (158 aa)
BAXBCL2 associated X, apoptosis regulator. (225 aa)
STAT6Signal transducer and activator of transcription 6. (932 aa)
E2F8E2F transcription factor 8. (896 aa)
LOC100229817Uncharacterized protein. (423 aa)
BTRCUncharacterized protein. (667 aa)
CDK5RAP3Uncharacterized protein. (477 aa)
ENSTGUP00000017345annotation not available (744 aa)
ASH1LASH1 like histone lysine methyltransferase. (2963 aa)
ENSTGUP00000018275Acyl-coenzyme A thioesterase 5-like. (411 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
HOXD13Homeobox domain-containing protein. (312 aa)
PYGO2Pygopus family PHD finger 2. (609 aa)
SCRIBScribble planar cell polarity protein. (1623 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
WT1WT1 transcription factor. (414 aa)
ARHGAP5Rho GTPase activating protein 5. (1505 aa)
MSANTD4Myb_DNA-bind_5 domain-containing protein. (343 aa)
ENSTGUP00000020434annotation not available (505 aa)
SEMA3CUncharacterized protein; Belongs to the semaphorin family. (751 aa)
CTC1Uncharacterized protein. (1000 aa)
GFERSulfhydryl oxidase. (215 aa)
CREB1cAMP responsive element binding protein 1. (324 aa)
ENSTGUP00000022263annotation not available (183 aa)
CSF1Macrophage colony-stimulating factor 1 precursor. (498 aa)
APOA1Uncharacterized protein. (264 aa)
ENSTGUP00000022493annotation not available (159 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (702 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4230 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (469 aa)
ENSTGUP00000023270annotation not available (573 aa)
TAF10Transcription initiation factor TFIID subunit 10. (200 aa)
LOC100225382Uncharacterized protein. (1621 aa)
NRG3Neuregulin 3. (425 aa)
OTPHomeobox protein orthopedia. (325 aa)
ENSTGUP00000023855annotation not available (1612 aa)
ENSTGUP00000024315annotation not available (176 aa)
COBLUncharacterized protein. (1393 aa)
LOC100225657-2Protein wntless homolog. (541 aa)
LOC100232675WD repeat domain 77. (365 aa)
ENSTGUP00000025007annotation not available (421 aa)
LHX4Uncharacterized protein. (340 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (317 aa)
PLAG1PLAG1 zinc finger. (501 aa)
NR3C2Nuclear receptor subfamily 3 group C member 2. (1010 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1595 aa)
ENSTGUP00000026483annotation not available (118 aa)
ENSTGUP00000027106annotation not available (269 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (459 aa)
TNFRSF11ATNFR-Cys domain-containing protein. (663 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
PLXND1Plexin D1. (1929 aa)
CRKLUncharacterized protein. (303 aa)
RB1CC1RB1 inducible coiled-coil 1. (1635 aa)
DNAAF1Dynein assembly factor 1, axonemal. (646 aa)
ENSTGUP00000028466annotation not available (76 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (189 aa)
H0YQU3_TAEGURho-GAP domain-containing protein. (480 aa)
CEBPBCCAAT/enhancer-binding protein. (324 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1282 aa)
ENSTGUP00000029939annotation not available (387 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (533 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (433 aa)
NKX2-5Homeobox domain-containing protein. (329 aa)
ZNF330Zinc finger protein 330. (321 aa)
ID1DNA-binding protein inhibitor ID-1. (162 aa)
GLI1Uncharacterized protein. (1276 aa)
FGL1Fibrinogen like 1. (374 aa)
TBX3T-box transcription factor TBX3. (731 aa)
LEF1Lymphoid enhancer binding factor 1. (412 aa)
CEBPB-2CCAAT enhancer binding protein beta. (324 aa)
GDF7Growth differentiation factor 7. (369 aa)
SMAD4SMAD family member 4. (514 aa)
TCF21Transcription factor 21. (179 aa)
ENSTGUP00000033710annotation not available (1605 aa)
LRRC1Leucine rich repeat containing 1. (795 aa)
ENSTGUP00000034670annotation not available (523 aa)
FADDFas associated via death domain. (221 aa)
LOC115498196Protransforming growth factor alpha-like. (316 aa)
XBP1X-box binding protein 1. (260 aa)
CACNB4SH3 domain-containing protein. (478 aa)
CLDN1Claudin 1. (213 aa)
H0Z6I1_TAEGUUncharacterized protein. (218 aa)
FRS2Fibroblast growth factor receptor substrate 2. (529 aa)
CEBPGCCAAT enhancer binding protein gamma. (149 aa)
LOC100218892Methylosome protein 50-like. (440 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (516 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (736 aa)
HOXD3Homeobox D3. (415 aa)
LOC115492668Medium-chain specific acyl-CoA dehydrogenase, mitochondrial. (422 aa)
ANXA1Annexin. (364 aa)
ESRP2Epithelial splicing regulatory protein 2. (727 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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