(47 nodes) NADP binding network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DHCR7	7-dehydrocholesterol reductase. (474 aa)
	CRYM	Crystallin mu. (317 aa)
	QDPR	Quinoid dihydropteridine reductase. (281 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (546 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (527 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (356 aa)
	ME3	Malic enzyme. (610 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1438 aa)
	CRYZ	Crystallin zeta. (497 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1145 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (773 aa)
	DHFR	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (190 aa)
	DUS2	Dihydrouridine synthase 2. (509 aa)
	LOC100220322	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1030 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1017 aa)
	LBR	Lamin B receptor. (685 aa)
	H6PD	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (790 aa)
	HSD17B1	Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (295 aa)
	NDOR1	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (636 aa)
	DECR1	Uncharacterized protein. (390 aa)
	PGD	Phosphogluconate dehydrogenase. (509 aa)
	ENSTGUP00000027443	annotation not available (203 aa)
	LOC100225021	Hydroxysteroid 11-beta dehydrogenase 1. (293 aa)
	ENSTGUP00000025643	annotation not available (189 aa)
	ASPDH	Putative L-aspartate dehydrogenase. (263 aa)
	NOS3	Nitric oxide synthase, endothelial isoform X2. (1216 aa)
	POR	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (677 aa)
	FMO5	Dimethylaniline monooxygenase [N-oxide-forming]. (719 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (517 aa)
	ENSTGUP00000038594	Translation initiation factor IF-2-like isoform X1. (746 aa)
	FMO1	Flavin-containing monooxygenase. (530 aa)
	HIBADH	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (409 aa)
	ENSTGUP00000037916	annotation not available (86 aa)
	KCNAB1	Aldo_ket_red domain-containing protein. (544 aa)
	ENSTGUP00000036048	annotation not available (549 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (547 aa)
	LOC100222111	Corticosteroid 11-beta-dehydrogenase isozyme 1-like. (298 aa)
	LOC115492494	Corticosteroid 11-beta-dehydrogenase isozyme 1-like. (298 aa)
	GRHPR	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)
	ENSTGUP00000032503	annotation not available (577 aa)
	GMDS	GDP-mannose 4,6-dehydratase. (403 aa)
	LOC115492063	Glucose-6-phosphate 1-dehydrogenase. (540 aa)
	ENSTGUP00000029807	annotation not available (300 aa)
	KCNAB2	Aldo_ket_red domain-containing protein. (416 aa)
	GLYR1	Glyoxylate reductase 1 homolog. (830 aa)
	ME1	Malic enzyme. (577 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAT	GSR	ENSTGUP00000035497	ENSTGUP00000020062	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.737
CAT	H6PD	ENSTGUP00000035497	ENSTGUP00000003853	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.540
CAT	HMGCR	ENSTGUP00000035497	ENSTGUP00000006291	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.524
CAT	MTRR	ENSTGUP00000035497	ENSTGUP00000007952	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	5-methyltetrahydrofolate-homocysteine methyltransferase reductase.	0.460
CAT	NDOR1	ENSTGUP00000035497	ENSTGUP00000002590	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.453
CAT	NOS1	ENSTGUP00000035497	ENSTGUP00000010731	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase; Produces nitric oxide (NO).	0.460
CAT	NOS2	ENSTGUP00000035497	ENSTGUP00000008940	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase; Produces nitric oxide (NO).	0.460
CAT	NOS3	ENSTGUP00000035497	ENSTGUP00000027262	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase, endothelial isoform X2.	0.460
CAT	POR	ENSTGUP00000035497	ENSTGUP00000023876	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.460
DHCR7	HMGCR	ENSTGUP00000020848	ENSTGUP00000006291	7-dehydrocholesterol reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.712
DHFR	DPYD	ENSTGUP00000007320	ENSTGUP00000005710	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.513
DHFR	ENSTGUP00000037916	ENSTGUP00000007320	ENSTGUP00000037916	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	annotation not available	0.501
DHFR	GAPDH	ENSTGUP00000007320	ENSTGUP00000013730	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.501
DHFR	GSR	ENSTGUP00000007320	ENSTGUP00000020062	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.616
DHFR	H6PD	ENSTGUP00000007320	ENSTGUP00000003853	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.697
DHFR	HMGCR	ENSTGUP00000007320	ENSTGUP00000006291	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.466
DHFR	QDPR	ENSTGUP00000007320	ENSTGUP00000018728	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Quinoid dihydropteridine reductase.	0.968
DPYD	DHFR	ENSTGUP00000005710	ENSTGUP00000007320	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.513
ENSTGUP00000025643	ENSTGUP00000037916	ENSTGUP00000025643	ENSTGUP00000037916	annotation not available	annotation not available	0.486
ENSTGUP00000025643	GAPDH	ENSTGUP00000025643	ENSTGUP00000013730	annotation not available	Glyceraldehyde-3-phosphate dehydrogenase.	0.486