STRINGSTRING
NKX2-5 NKX2-5 TGFB2 TGFB2 CAV2 CAV2 ATP5F1A ATP5F1A ENSTGUP00000029033 ENSTGUP00000029033 AGTR1 AGTR1 KDR KDR ST8SIA1 ST8SIA1 LOC100231563 LOC100231563 JCAD JCAD ESRP2 ESRP2 NKX2-8 NKX2-8 ENSTGUP00000038186 ENSTGUP00000038186 MMRN2 MMRN2 LOC105759334 LOC105759334 VASH2 VASH2 LOC115498196 LOC115498196 HOXA5 HOXA5 ETV4 ETV4 RPTOR RPTOR ITGB3 ITGB3 LOC100230282 LOC100230282 SIRT1 SIRT1 NLRC3 NLRC3 AIMP1 AIMP1 AGGF1 AGGF1 APOH APOH IFT52 IFT52 NFIB NFIB CTNNB1 CTNNB1 MST1 MST1 F3 F3 XBP1 XBP1 CDC42 CDC42 CLDN1 CLDN1 LOC115491349 LOC115491349 PGF PGF PYGO2 PYGO2 LOC115491390 LOC115491390 BAX BAX LOC100222335 LOC100222335 IFT172 IFT172 GRN GRN ADAM17 ADAM17 AQP11 AQP11 BCL11B BCL11B CDKN1B CDKN1B MYC MYC CNMD CNMD TBC1D31 TBC1D31 CPB2 CPB2 TRIM24 TRIM24 RB1 RB1 OSR2 OSR2 BRCA2 BRCA2 THBS1 THBS1 PDX1 PDX1 SULF1 SULF1 CYP7B1 CYP7B1 VIP VIP IFT80 IFT80 PDCD10 PDCD10 TNFAIP3 TNFAIP3 DLL4 DLL4 LOC100229685 LOC100229685 ATOH8 ATOH8 MDK MDK CAV3 CAV3 FZD7 FZD7 BMPR2 BMPR2 HRAS HRAS HTR2B HTR2B LIMS1 LIMS1 FMC1 FMC1 MAP2K5 MAP2K5 ITGA4 ITGA4 NKX2-3 NKX2-3 IGF2 IGF2 PHOX2B PHOX2B VEGFD VEGFD SCG2 SCG2 LIMS2 LIMS2 TIE1 TIE1 ARX ARX A4GNT A4GNT TGFBR1 TGFBR1 VEGFC VEGFC PRL PRL FA2H FA2H HMGB2 HMGB2 JAG1 JAG1 BIRC5 BIRC5 SERPINF1 SERPINF1 DBH DBH NGFR NGFR FRS2 FRS2 ECM1 ECM1 LOC100218892 LOC100218892 SAV1 SAV1 ENSTGUP00000034917 ENSTGUP00000034917 PROK2 PROK2 NRARP NRARP WNT3A WNT3A ENSTGUP00000019172 ENSTGUP00000019172 BMP6 BMP6 FGF7 FGF7 PIK3CD PIK3CD PDGFB PDGFB ENSTGUP00000020883 ENSTGUP00000020883 FLCN FLCN LOC115491405 LOC115491405 OSR1 OSR1 LOC100224755 LOC100224755 MTSS1 MTSS1 PPARD PPARD TP63 TP63 NME2 NME2 ENSTGUP00000023034 ENSTGUP00000023034 IFT57 IFT57 DEAF1 DEAF1 FGF1 FGF1 DRD2 DRD2 WDR48 WDR48 GAS1 GAS1 MYDGF MYDGF KDF1 KDF1 SIRT6 SIRT6 NRAS NRAS FLT4 FLT4 IL10 IL10 KRIT1 KRIT1 IRF6-2 IRF6-2 H0YTF5_TAEGU H0YTF5_TAEGU LOC100218902 LOC100218902 DLX6 DLX6 DLX5 DLX5 H0YUE5_TAEGU H0YUE5_TAEGU SMO SMO INTU INTU GATA3 GATA3 DAB2 DAB2 TNMD TNMD ERRFI1 ERRFI1 HLX HLX AR AR SOX9 SOX9 VEGFA VEGFA EFNB2 EFNB2 FGF2 FGF2 ENSTGUP00000024522 ENSTGUP00000024522 CDKN1C CDKN1C LOC100232675 LOC100232675 CASK CASK STXBP4 STXBP4 VASH1 VASH1 CAV1 CAV1 MED1 MED1 PEX2 PEX2 PKHD1 PKHD1 H1A5C0_TAEGU H1A5C0_TAEGU LEP LEP MCC MCC DUSP10 DUSP10 SRSF3 SRSF3 APELA APELA APLNR APLNR PGR PGR PTPRK PTPRK NR1D1 NR1D1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX2-5Homeobox domain-containing protein. (329 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (433 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (585 aa)
ENSTGUP00000029033annotation not available (311 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (359 aa)
LOC100231563Nuclear receptor subfamily 4 group A member 1. (574 aa)
JCADJunctional cadherin 5 associated. (1330 aa)
ESRP2Epithelial splicing regulatory protein 2. (727 aa)
NKX2-8Homeobox protein Nkx-2.8. (236 aa)
ENSTGUP00000038186annotation not available (484 aa)
MMRN2Multimerin 2. (1012 aa)
LOC105759334PDZ domain-containing protein. (188 aa)
VASH2Vasohibin 2. (367 aa)
LOC115498196Protransforming growth factor alpha-like. (316 aa)
HOXA5Homeobox A5. (270 aa)
ETV4ETS variant 4. (453 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1358 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (797 aa)
LOC100230282Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (586 aa)
SIRT1Sirtuin 1. (750 aa)
NLRC3NLR family CARD domain containing 3. (1006 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (318 aa)
AGGF1Uncharacterized protein. (707 aa)
APOHUncharacterized protein. (350 aa)
IFT52Uncharacterized protein. (503 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (569 aa)
CTNNB1Catenin beta 1. (781 aa)
MST1Macrophage stimulating 1. (705 aa)
F3Coagulation factor III, tissue factor. (402 aa)
XBP1X-box binding protein 1. (260 aa)
CDC42Cell division cycle 42. (302 aa)
CLDN1Claudin 1. (213 aa)
LOC115491349Transcription factor Sp1. (764 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (255 aa)
PYGO2Pygopus family PHD finger 2. (609 aa)
LOC115491390Nuclear receptor subfamily 4 group A member 1. (574 aa)
BAXBCL2 associated X, apoptosis regulator. (225 aa)
LOC100222335EGF-like domain-containing protein. (158 aa)
IFT172Uncharacterized protein. (1748 aa)
GRNGranulin precursor. (611 aa)
ADAM17ADAM metallopeptidase domain 17. (918 aa)
AQP11Aquaporin 11. (273 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (883 aa)
CDKN1BPutative cyclin-dependent kinase inhibitor 1B. (198 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
CNMDChondromodulin. (344 aa)
TBC1D31TBC1 domain family member 31. (1046 aa)
CPB2Carboxypeptidase B2. (424 aa)
TRIM24Tripartite motif containing 24. (1047 aa)
RB1RB transcriptional corepressor 1. (931 aa)
OSR2Odd-skipped related transciption factor 2. (311 aa)
BRCA2BRCA2 DNA repair associated. (3359 aa)
THBS1Uncharacterized protein. (1173 aa)
PDX1Homeobox domain-containing protein. (260 aa)
SULF1Extracellular sulfatase. (1120 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
VIPVasoactive intestinal peptide. (215 aa)
IFT80Intraflagellar transport 80. (267 aa)
PDCD10Programmed cell death 10. (212 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (683 aa)
LOC100229685Uncharacterized protein. (183 aa)
ATOH8BHLH domain-containing protein. (330 aa)
MDKMidkine. (139 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
HRASPutative v-Ha-ras Harvey sarcoma viral oncogene variant 2. (189 aa)
HTR2B5-hydroxytryptamine receptor 2B. (463 aa)
LIMS1LIM domain-containing protein. (387 aa)
FMC1Uncharacterized protein. (107 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (447 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1024 aa)
NKX2-3NK2 homeobox 3. (327 aa)
IGF2IlGF domain-containing protein. (225 aa)
PHOX2BPaired like homeobox 2B. (294 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
SCG2Secretogranin II. (625 aa)
LIMS2LIM domain-containing protein. (339 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1124 aa)
ARXAristaless related homeobox. (567 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (392 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (468 aa)
PRLProlactin. (209 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (401 aa)
HMGB2High mobility group box 2. (208 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
BIRC5Baculoviral IAP repeat containing 5. (140 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (416 aa)
DBHDopamine beta-hydroxylase. (643 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (475 aa)
FRS2Fibroblast growth factor receptor substrate 2. (529 aa)
ECM1Extracellular matrix protein 1. (419 aa)
LOC100218892Methylosome protein 50-like. (440 aa)
SAV1Salvador family WW domain containing protein 1. (379 aa)
ENSTGUP00000034917annotation not available (676 aa)
PROK2Prokineticin 2. (116 aa)
NRARPNOTCH regulated ankyrin repeat protein. (117 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ENSTGUP00000019172annotation not available (72 aa)
BMP6Bone morphogenetic protein 6. (414 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (278 aa)
ENSTGUP00000020883Homeobox protein aristaless-related. (294 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
LOC115491405Serine/threonine-protein kinase receptor R3 isoform X2. (493 aa)
OSR1Protein odd-skipped-related 1. (260 aa)
LOC100224755Transcription factor Sp1-like. (764 aa)
MTSS1MTSS I-BAR domain containing 1. (787 aa)
PPARDUncharacterized protein. (449 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (702 aa)
NME2Nucleoside diphosphate kinase. (325 aa)
ENSTGUP00000023034annotation not available (327 aa)
IFT57Ig-like domain-containing protein. (657 aa)
DEAF1DEAF1 transcription factor. (607 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (473 aa)
WDR48WD repeat domain 48. (675 aa)
GAS1Uncharacterized protein. (159 aa)
MYDGFMyeloid derived growth factor. (298 aa)
KDF1Keratinocyte differentiation factor 1. (413 aa)
SIRT6Sirtuin 6. (348 aa)
NRASNRAS proto-oncogene, GTPase. (280 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1379 aa)
IL10Interleukin 10. (165 aa)
KRIT1Uncharacterized protein. (736 aa)
IRF6-2Interferon regulatory factor 6. (460 aa)
H0YTF5_TAEGUANK_REP_REGION domain-containing protein. (133 aa)
LOC100218902ANK_REP_REGION domain-containing protein. (294 aa)
DLX6Distal-less homeobox 6. (268 aa)
DLX5Distal-less homeobox 5. (290 aa)
H0YUE5_TAEGUMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (590 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
INTUInturned planar cell polarity protein. (919 aa)
GATA3GATA binding protein 3. (443 aa)
DAB2DAB adaptor protein 2. (716 aa)
TNMDTenomodulin. (332 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (463 aa)
HLXH2.0 like homeobox. (425 aa)
ARAndrogen receptor. (684 aa)
SOX9SRY-box transcription factor 9. (474 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (364 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
ENSTGUP00000024522annotation not available (197 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C isoform X1. (181 aa)
LOC100232675WD repeat domain 77. (365 aa)
CASKUncharacterized protein; Belongs to the MAGUK family. (921 aa)
STXBP4Syntaxin binding protein 4. (723 aa)
VASH1Vasohibin 1. (349 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
PEX2Peroxisomal biogenesis factor 2. (304 aa)
PKHD1Uncharacterized protein. (3650 aa)
H1A5C0_TAEGUUncharacterized protein. (432 aa)
LEPTaeniopygia guttata leptin (LEP), mRNA. (168 aa)
MCCMCC regulator of WNT signaling pathway. (919 aa)
DUSP10Dual specificity phosphatase 10. (481 aa)
SRSF3Uncharacterized protein. (242 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
APLNRUncharacterized protein. (371 aa)
PGRProgesterone receptor. (776 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1490 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (553 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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