(85 nodes) Positive regulation of epithelial cell proliferation network (Taeniopygia guttata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (797 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	WDR48	WD repeat domain 48. (675 aa)
	GAS1	Uncharacterized protein. (159 aa)
	MYDGF	Myeloid derived growth factor. (298 aa)
	SIRT6	Sirtuin 6. (348 aa)
	NRAS	NRAS proto-oncogene, GTPase. (280 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1379 aa)
	IL10	Interleukin 10. (165 aa)
	DLX6	Distal-less homeobox 6. (268 aa)
	DLX5	Distal-less homeobox 5. (290 aa)
	H0YUE5_TAEGU	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (590 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
	HLX	H2.0 like homeobox. (425 aa)
	AR	Androgen receptor. (684 aa)
	SOX9	SRY-box transcription factor 9. (474 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1358 aa)
	LOC100230282	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (586 aa)
	SIRT1	Sirtuin 1. (750 aa)
	AGGF1	Uncharacterized protein. (707 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	MST1	Macrophage stimulating 1. (705 aa)
	F3	Coagulation factor III, tissue factor. (402 aa)
	HMGB2	High mobility group box 2. (208 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (468 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
	SCG2	Secretogranin II. (625 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
	IGF2	IlGF domain-containing protein. (225 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1024 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (447 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (463 aa)
	HRAS	Putative v-Ha-ras Harvey sarcoma viral oncogene variant 2. (189 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
	MDK	Midkine. (139 aa)
	TNFAIP3	TNF alpha induced protein 3. (804 aa)
	VIP	Vasoactive intestinal peptide. (215 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
	PDX1	Homeobox domain-containing protein. (260 aa)
	OSR2	Odd-skipped related transciption factor 2. (311 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
	ADAM17	ADAM metallopeptidase domain 17. (918 aa)
	GRN	Granulin precursor. (611 aa)
	LOC100222335	EGF-like domain-containing protein. (158 aa)
	LOC115491390	Nuclear receptor subfamily 4 group A member 1. (574 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (255 aa)
	LOC115491349	Transcription factor Sp1. (764 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	ENSTGUP00000019172	annotation not available (72 aa)
	BMP6	Bone morphogenetic protein 6. (414 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (278 aa)
	LOC115491405	Serine/threonine-protein kinase receptor R3 isoform X2. (493 aa)
	OSR1	Protein odd-skipped-related 1. (260 aa)
	LOC100224755	Transcription factor Sp1-like. (764 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (702 aa)
	NME2	Nucleoside diphosphate kinase. (325 aa)
	ENSTGUP00000023034	annotation not available (327 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
	ENSTGUP00000024522	annotation not available (197 aa)
	STXBP4	Syntaxin binding protein 4. (723 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	PKHD1	Uncharacterized protein. (3650 aa)
	H1A5C0_TAEGU	Uncharacterized protein. (432 aa)
	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (359 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	NKX2-5	Homeobox domain-containing protein. (329 aa)
	APLNR	Uncharacterized protein. (371 aa)
	APELA	Apelin receptor early endogenous ligand. (54 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (117 aa)
	PROK2	Prokineticin 2. (116 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	LOC100231563	Nuclear receptor subfamily 4 group A member 1. (574 aa)
	JCAD	Junctional cadherin 5 associated. (1330 aa)
	LOC115498196	Protransforming growth factor alpha-like. (316 aa)
	XBP1	X-box binding protein 1. (260 aa)
	CDC42	Cell division cycle 42. (302 aa)
	CLDN1	Claudin 1. (213 aa)
	ECM1	Extracellular matrix protein 1. (419 aa)
	VASH2	Vasohibin 2. (367 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (727 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	LOC100222335	ENSTGUP00000013420	ENSTGUP00000015746	ADAM metallopeptidase domain 17.	EGF-like domain-containing protein.	0.461
ADAM17	LOC115498196	ENSTGUP00000013420	ENSTGUP00000035870	ADAM metallopeptidase domain 17.	Protransforming growth factor alpha-like.	0.461
AGTR1	APLNR	ENSTGUP00000034966	ENSTGUP00000031996	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.705
AGTR1	ENSTGUP00000019172	ENSTGUP00000034966	ENSTGUP00000019172	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	annotation not available	0.690
APELA	APLNR	ENSTGUP00000032014	ENSTGUP00000031996	Apelin receptor early endogenous ligand.	Uncharacterized protein.	0.900
APELA	ENSTGUP00000019172	ENSTGUP00000032014	ENSTGUP00000019172	Apelin receptor early endogenous ligand.	annotation not available	0.660
APLNR	AGTR1	ENSTGUP00000031996	ENSTGUP00000034966	Uncharacterized protein.	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.705
APLNR	APELA	ENSTGUP00000031996	ENSTGUP00000032014	Uncharacterized protein.	Apelin receptor early endogenous ligand.	0.900
APLNR	ENSTGUP00000019172	ENSTGUP00000031996	ENSTGUP00000019172	Uncharacterized protein.	annotation not available	0.912
AR	CTNNB1	ENSTGUP00000002859	ENSTGUP00000004945	Androgen receptor.	Catenin beta 1.	0.882
AR	H0YUE5_TAEGU	ENSTGUP00000002859	ENSTGUP00000001913	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.527
AR	LOC100224755	ENSTGUP00000002859	ENSTGUP00000022545	Androgen receptor.	Transcription factor Sp1-like.	0.515
AR	LOC115491349	ENSTGUP00000002859	ENSTGUP00000018906	Androgen receptor.	Transcription factor Sp1.	0.515
AR	MED1	ENSTGUP00000002859	ENSTGUP00000028044	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.527
AR	WDR48	ENSTGUP00000002859	ENSTGUP00000000482	Androgen receptor.	WD repeat domain 48.	0.632
BMP6	BMPR2	ENSTGUP00000019464	ENSTGUP00000010438	Bone morphogenetic protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.972
BMP6	LOC100230282	ENSTGUP00000019464	ENSTGUP00000003374	Bone morphogenetic protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.403
BMP6	LOC115491405	ENSTGUP00000019464	ENSTGUP00000021756	Bone morphogenetic protein 6.	Serine/threonine-protein kinase receptor R3 isoform X2.	0.403
BMPR2	BMP6	ENSTGUP00000010438	ENSTGUP00000019464	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 6.	0.972
BMPR2	LOC100230282	ENSTGUP00000010438	ENSTGUP00000003374	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.814