(74 nodes) Positive regulation of synaptic transmission network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZDHHC12	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (200 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (938 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1554 aa)
	TSHZ3	Teashirt zinc finger homeobox 3. (1079 aa)
	SLC24A1	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (660 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1503 aa)
	CA7	Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
	RAPSN	TPR_REGION domain-containing protein. (420 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
	LRRTM1	Leucine rich repeat transmembrane neuronal 1. (485 aa)
	LOC100220528	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (171 aa)
	NPS	Neuropeptide S. (84 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1655 aa)
	CLSTN3	Calsyntenin 3. (1017 aa)
	SQSTM1	Uncharacterized protein. (453 aa)
	LRRTM2	Leucine rich repeat transmembrane neuronal 2. (517 aa)
	PINK1	PTEN induced kinase 1. (515 aa)
	CLSTN1	Calsyntenin 1. (961 aa)
	LAMA2	Uncharacterized protein. (3342 aa)
	ENSTGUP00000019777	annotation not available (790 aa)
	ENSTGUP00000020579	annotation not available (505 aa)
	IGSF11	Immunoglobulin superfamily member 11. (441 aa)
	ENSTGUP00000021114	annotation not available (325 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (987 aa)
	ENSTGUP00000021498	annotation not available (382 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (2565 aa)
	ENSTGUP00000022270	annotation not available (371 aa)
	ENSTGUP00000023319	annotation not available (371 aa)
	NALCN	Sodium leak channel, non-selective. (1762 aa)
	LGMN	Uncharacterized protein. (431 aa)
	CACNG5	Calcium voltage-gated channel auxiliary subunit gamma 5. (279 aa)
	CRTC1	CREB regulated transcription coactivator 1. (620 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1319 aa)
	GRIN2D	Glutamate receptor ionotropic, NMDA 2D isoform X1. (1086 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1606 aa)
	ENSTGUP00000026940	annotation not available (508 aa)
	CLSTN2	Calsyntenin 2. (945 aa)
	NRXN2	Neurexin 2. (1546 aa)
	ENSTGUP00000029224	annotation not available (99 aa)
	DTNBP1	Dystrobrevin binding protein 1. (351 aa)
	APP	Amyloid beta precursor protein. (797 aa)
	ENSTGUP00000029532	annotation not available (502 aa)
	SYT12	Synaptotagmin 12. (472 aa)
	ENSTGUP00000037955	annotation not available (541 aa)
	ENSTGUP00000037430	annotation not available (83 aa)
	LGI1	Leucine rich glioma inactivated 1. (543 aa)
	FMR1	Fragile X mental retardation 1. (548 aa)
	NRXN1	Neurexin 1. (1499 aa)
	ENSTGUP00000036921	annotation not available (155 aa)
	ENSTGUP00000036627	annotation not available (283 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (274 aa)
	CACNB4	SH3 domain-containing protein. (478 aa)
	ENSTGUP00000036039	annotation not available (290 aa)
	NPTN	Neuroplastin. (396 aa)
	NRGN	Neurogranin. (124 aa)
	ENSTGUP00000033290	annotation not available (332 aa)
	RIMS2	Uncharacterized protein. (1488 aa)
	STX2	Syntaxin 2; Belongs to the syntaxin family. (593 aa)
	SNAP47	Synaptosome associated protein 47. (506 aa)
	SLC1A3	Amino acid transporter. (543 aa)
	STX1B	Syntaxin-1B isoform X1. (288 aa)
	STX1A	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (313 aa)
	SLC4A8	Anion exchange protein. (1078 aa)
	SLC24A2	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (650 aa)
	ENSTGUP00000004504	annotation not available (279 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1470 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1826 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	STX3	Syntaxin 3. (331 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1142 aa)
	ENSTGUP00000032412	annotation not available (208 aa)
	ENSTGUP00000031243	annotation not available (686 aa)
	CDK5	Cyclin-dependent-like kinase 5. (808 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY8	ENSTGUP00000007377	ENSTGUP00000025787	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.959
ADCY8	ADCY1	ENSTGUP00000025787	ENSTGUP00000007377	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.959
ADCY8	GRIN2A	ENSTGUP00000025787	ENSTGUP00000004929	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.450
APP	CDK5	ENSTGUP00000029357	ENSTGUP00000030783	Amyloid beta precursor protein.	Cyclin-dependent-like kinase 5.	0.504
APP	CLSTN1	ENSTGUP00000029357	ENSTGUP00000018793	Amyloid beta precursor protein.	Calsyntenin 1.	0.455
APP	FMR1	ENSTGUP00000029357	ENSTGUP00000037101	Amyloid beta precursor protein.	Fragile X mental retardation 1.	0.424
APP	GRIN2A	ENSTGUP00000029357	ENSTGUP00000004929	Amyloid beta precursor protein.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.428
APP	GRIN2B	ENSTGUP00000029357	ENSTGUP00000009760	Amyloid beta precursor protein.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.469
CACNB4	CACNG2	ENSTGUP00000036191	ENSTGUP00000011052	SH3 domain-containing protein.	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.813
CACNB4	CACNG4	ENSTGUP00000036191	ENSTGUP00000004516	SH3 domain-containing protein.	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.438
CACNB4	ENSTGUP00000033290	ENSTGUP00000036191	ENSTGUP00000033290	SH3 domain-containing protein.	annotation not available	0.438
CACNB4	ENSTGUP00000036039	ENSTGUP00000036191	ENSTGUP00000036039	SH3 domain-containing protein.	annotation not available	0.438
CACNB4	GRIN2A	ENSTGUP00000036191	ENSTGUP00000004929	SH3 domain-containing protein.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.514
CACNB4	NALCN	ENSTGUP00000036191	ENSTGUP00000023340	SH3 domain-containing protein.	Sodium leak channel, non-selective.	0.528
CACNB4	RIMS2	ENSTGUP00000036191	ENSTGUP00000033110	SH3 domain-containing protein.	Uncharacterized protein.	0.414
CACNG2	CACNB4	ENSTGUP00000011052	ENSTGUP00000036191	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	SH3 domain-containing protein.	0.813
CACNG2	CACNG4	ENSTGUP00000011052	ENSTGUP00000004516	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.431
CACNG2	GRIN2A	ENSTGUP00000011052	ENSTGUP00000004929	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.454
CACNG2	GRIN2B	ENSTGUP00000011052	ENSTGUP00000009760	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.477
CACNG2	GRIN2C	ENSTGUP00000011052	ENSTGUP00000009145	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor NMDA type subunit 2C.	0.427