(116 nodes) Regulation of chemotaxis network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL34	Uncharacterized protein. (226 aa)
	LOC100221351	C-C motif chemokine 16. (127 aa)
	CXCL8-3	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (102 aa)
	DNM1L	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
	ARTN	Artemin. (236 aa)
	SEMA5B	Semaphorin 5B. (1092 aa)
	LOC100218724	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (729 aa)
	CCL19	C-C motif chemokine ligand 19. (152 aa)
	ENSTGUP00000029281	annotation not available (729 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
	GAS6	Growth arrest specific 6. (704 aa)
	LOC100223328	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	LOC100222345	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	CXCL8	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (107 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (820 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (775 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (779 aa)
	FGF4	Fibroblast growth factor 4. (194 aa)
	SEMA7A	Sema domain-containing protein. (633 aa)
	RARRES2	Retinoic acid receptor responder protein 2 precursor. (491 aa)
	SEMA3D	Uncharacterized protein; Belongs to the semaphorin family. (761 aa)
	ENSTGUP00000027497	annotation not available (154 aa)
	BST1	Bone marrow stromal cell antigen 1. (316 aa)
	ANO6	Anoctamin. (907 aa)
	NINJ1	Ninjurin 1. (173 aa)
	LOC100228042	Uncharacterized protein. (678 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (1032 aa)
	LYN	Tyrosine-protein kinase. (605 aa)
	LGMN	Uncharacterized protein. (431 aa)
	ENSTGUP00000024560	annotation not available (98 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (364 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (420 aa)
	SEMA4G	Semaphorin 4G; Belongs to the semaphorin family. (844 aa)
	CREB3	BZIP domain-containing protein. (428 aa)
	CSF1	Macrophage colony-stimulating factor 1 precursor. (498 aa)
	MYCBP2	MYC binding protein 2. (4725 aa)
	SEMA3C	Uncharacterized protein; Belongs to the semaphorin family. (751 aa)
	C1QBP	Complement C1q binding protein. (287 aa)
	TIRAP	TIR domain containing adaptor protein. (410 aa)
	LOC115491418	Growth differentiation factor 11. (377 aa)
	CD74	Uncharacterized protein. (289 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (278 aa)
	ENSTGUP00000019835	annotation not available (1860 aa)
	LOC100228042-2	PAD domain-containing protein. (680 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (255 aa)
	CXCL12	Putative stromal cell derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family. (203 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	GPR18	G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (321 aa)
	LOC100230782	Uncharacterized protein; Belongs to the parvalbumin family. (116 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1044 aa)
	CXCL14	Uncharacterized protein. (98 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC100227529	SCY domain-containing protein. (101 aa)
	ADAM17	ADAM metallopeptidase domain 17. (918 aa)
	ANGPT2	Angiopoietin 2. (494 aa)
	RIN3	Ras and Rab interactor 3. (968 aa)
	FAM49B	Family with sequence similarity 49 member B. (324 aa)
	CCN3	Cellular communication network factor 3. (377 aa)
	TNFAIP6	TNF alpha induced protein 6. (296 aa)
	THBS1	Uncharacterized protein. (1173 aa)
	SUCNR1	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (303 aa)
	VAX1	Ventral anterior homeobox 1. (320 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (381 aa)
	MSTN	Myostatin. (375 aa)
	MDK	Midkine. (139 aa)
	HRG	Uncharacterized protein. (626 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase. (485 aa)
	LOC115494591	Protein-tyrosine kinase 2-beta. (1047 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (568 aa)
	SEMA6B	Semaphorin-6B. (906 aa)
	RIPOR2	PL48 domain-containing protein. (1132 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (830 aa)
	PRSS56	Peptidase S1 domain-containing protein. (568 aa)
	SLIT1	Slit guidance ligand 1. (1538 aa)
	SLIT2	Slit guidance ligand 2. (1541 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	SLC8B1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (571 aa)
	MOSPD2	Motile sperm domain containing 2. (518 aa)
	SWAP70	Switching B cell complex subunit SWAP70. (584 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1413 aa)
	SCG2	Secretogranin II. (625 aa)
	SEMA5A	Semaphorin 5A. (1076 aa)
	STK39	Serine/threonine kinase 39. (495 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1088 aa)
	CYP19A1	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (509 aa)
	MPP1	Membrane palmitoylated protein 1; Belongs to the MAGUK family. (486 aa)
	H0Z8Z3_TAEGU	Uncharacterized protein; Belongs to the peptidase S9B family. (672 aa)
	TBR1	T-box brain transcription factor 1. (642 aa)
	C5	Uncharacterized protein. (1678 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (755 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (468 aa)
	SEMA3G	Semaphorin 3G; Belongs to the semaphorin family. (771 aa)
	ADAM10	ADAM metallopeptidase domain 10. (911 aa)
	NELL2	Neural EGFL like 2. (816 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (817 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	MST1	Macrophage stimulating 1. (705 aa)
	LOC100224101	Uncharacterized protein; Belongs to the semaphorin family. (765 aa)
	MMP28	Matrix metallopeptidase 28. (463 aa)
	NELL1	Neural EGFL like 1. (808 aa)
	RYK	Receptor like tyrosine kinase. (696 aa)
	LOC100219655	semaphorin-7A. (1169 aa)
	SEMA6C	Semaphorin 6C. (963 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	OXSR1	Oxidative stress responsive kinase 1. (551 aa)
	CXCL8-2	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (184 aa)
	LOC100226999	Semaphorin-4C. (860 aa)
	JAM3	Uncharacterized protein. (312 aa)
	SEMA4C	Sema domain-containing protein; Belongs to the semaphorin family. (907 aa)
	ATOH7	Atonal bHLH transcription factor 7. (151 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	CX3CR1	ENSTGUP00000006279	ENSTGUP00000018257	ADAM metallopeptidase domain 10.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.510
ANGPT2	CSF1R	ENSTGUP00000013276	ENSTGUP00000000996	Angiopoietin 2.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.736
ANGPT2	KDR	ENSTGUP00000013276	ENSTGUP00000029011	Angiopoietin 2.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.822
ANGPT2	LOC100222345	ENSTGUP00000013276	ENSTGUP00000001591	Angiopoietin 2.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.504
ANGPT2	MET	ENSTGUP00000013276	ENSTGUP00000005389	Angiopoietin 2.	MET proto-oncogene, receptor tyrosine kinase.	0.680
ANGPT2	PDGFB	ENSTGUP00000013276	ENSTGUP00000020140	Angiopoietin 2.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.481
ANGPT2	PGF	ENSTGUP00000013276	ENSTGUP00000018869	Angiopoietin 2.	Placental growth factor; Belongs to the PDGF/VEGF growth factor family.	0.592
ANGPT2	THBS1	ENSTGUP00000013276	ENSTGUP00000011992	Angiopoietin 2.	Uncharacterized protein.	0.480
ANGPT2	VEGFC	ENSTGUP00000013276	ENSTGUP00000006624	Angiopoietin 2.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.489
CCL19	CCR6	ENSTGUP00000030305	ENSTGUP00000009852	C-C motif chemokine ligand 19.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.438
CCL19	CCR7	ENSTGUP00000030305	ENSTGUP00000002421	C-C motif chemokine ligand 19.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.880
CCL19	CX3CR1	ENSTGUP00000030305	ENSTGUP00000018257	C-C motif chemokine ligand 19.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.603
CCL19	CXCL12	ENSTGUP00000030305	ENSTGUP00000018339	C-C motif chemokine ligand 19.	Putative stromal cell derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family.	0.863
CCL19	CXCL14	ENSTGUP00000030305	ENSTGUP00000017507	C-C motif chemokine ligand 19.	Uncharacterized protein.	0.427
CCL19	CXCL8	ENSTGUP00000030305	ENSTGUP00000001780	C-C motif chemokine ligand 19.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.486
CCL19	CXCL8-2	ENSTGUP00000030305	ENSTGUP00000034706	C-C motif chemokine ligand 19.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.666
CCL19	CXCL8-3	ENSTGUP00000030305	ENSTGUP00000037995	C-C motif chemokine ligand 19.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.427
CCL19	LOC100218724	ENSTGUP00000030305	ENSTGUP00000031646	C-C motif chemokine ligand 19.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.563
CCL19	LOC100222345	ENSTGUP00000030305	ENSTGUP00000001591	C-C motif chemokine ligand 19.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.625
CCL19	LOC100223328	ENSTGUP00000030305	ENSTGUP00000001587	C-C motif chemokine ligand 19.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.488