(41 nodes) Neuron apoptotic process network (Taeniopygia guttata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	RB1	RB transcriptional corepressor 1. (931 aa)
	DNAJC5	DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
	DNAJC5G	J domain-containing protein. (661 aa)
	AIFM1	Uncharacterized protein. (593 aa)
	NEFL	Neurofilament light; Belongs to the intermediate filament family. (570 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16. (475 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (807 aa)
	FADD	Fas associated via death domain. (221 aa)
	ENSTGUP00000032655	annotation not available (422 aa)
	SNCB	Uncharacterized protein. (240 aa)
	AARS1	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (999 aa)
	ENSTGUP00000031473	annotation not available (499 aa)
	CDK5	Cyclin-dependent-like kinase 5. (808 aa)
	OXR1	Oxidation resistance 1. (893 aa)
	DNAJC5B	DnaJ heat shock protein family (Hsp40) member C5 beta. (196 aa)
	LOC100224555	Activity dependent neuroprotector homeobox. (1226 aa)
	APP	Amyloid beta precursor protein. (797 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	NES	IF rod domain-containing protein; Belongs to the intermediate filament family. (1641 aa)
	TNFRSF21	TNF receptor superfamily member 21. (658 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (702 aa)
	FAM162A	Protein FAM162A. (173 aa)
	ENSTGUP00000021519	annotation not available (333 aa)
	CLN8	TLC domain-containing protein. (300 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (420 aa)
	PIGT	Uncharacterized protein. (786 aa)
	BAX	BCL2 associated X, apoptosis regulator. (225 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (527 aa)
	ATM	Non-specific serine/threonine protein kinase. (2226 aa)
	TMTC4	Transmembrane O-mannosyltransferase targeting cadherins 4. (740 aa)
	CASP7	Uncharacterized protein; Belongs to the peptidase C14A family. (309 aa)
	ROCK1	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1358 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2370 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2076 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	ADNP	Activity-dependent neuroprotector homeobox protein isoform X1. (1226 aa)
	DLX1	Distal-less homeobox 1. (245 aa)
	BCL2L1	BCL2 like 1. (230 aa)
	DIABLO	Uncharacterized protein. (236 aa)
	NCSTN	Nicastrin. (879 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	APAF1	ENSTGUP00000037952	ENSTGUP00000009081	Uncharacterized protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.515
AIFM1	BCL2L1	ENSTGUP00000037952	ENSTGUP00000006866	Uncharacterized protein.	BCL2 like 1.	0.402
AIFM1	CASP9	ENSTGUP00000037952	ENSTGUP00000017449	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.559
AIFM1	DIABLO	ENSTGUP00000037952	ENSTGUP00000006354	Uncharacterized protein.	Uncharacterized protein.	0.558
APAF1	AIFM1	ENSTGUP00000009081	ENSTGUP00000037952	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.515
APAF1	ATM	ENSTGUP00000009081	ENSTGUP00000013001	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Non-specific serine/threonine protein kinase.	0.482
APAF1	BAX	ENSTGUP00000009081	ENSTGUP00000015983	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.760
APAF1	BCL2L1	ENSTGUP00000009081	ENSTGUP00000006866	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.830
APAF1	CASP7	ENSTGUP00000009081	ENSTGUP00000011206	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.885
APAF1	CASP9	ENSTGUP00000009081	ENSTGUP00000017449	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	DIABLO	ENSTGUP00000009081	ENSTGUP00000006354	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.941
APAF1	ENSTGUP00000021519	ENSTGUP00000009081	ENSTGUP00000021519	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	annotation not available	0.654
APAF1	ENSTGUP00000032655	ENSTGUP00000009081	ENSTGUP00000032655	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	annotation not available	0.654
APAF1	FADD	ENSTGUP00000009081	ENSTGUP00000034889	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas associated via death domain.	0.540
APAF1	TP63	ENSTGUP00000009081	ENSTGUP00000022691	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.531
APP	CDK5	ENSTGUP00000029357	ENSTGUP00000030783	Amyloid beta precursor protein.	Cyclin-dependent-like kinase 5.	0.504
APP	NCSTN	ENSTGUP00000029357	ENSTGUP00000004510	Amyloid beta precursor protein.	Nicastrin.	0.942
APP	NEFL	ENSTGUP00000029357	ENSTGUP00000037222	Amyloid beta precursor protein.	Neurofilament light; Belongs to the intermediate filament family.	0.457
APP	NGFR	ENSTGUP00000029357	ENSTGUP00000036482	Amyloid beta precursor protein.	Tumor necrosis factor receptor superfamily member 16.	0.776
APP	PSEN1	ENSTGUP00000029357	ENSTGUP00000027530	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.962