(30 nodes) Negative regulation of protein kinase B signaling network (Taeniopygia guttata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DAG1	Dystroglycan 1. (896 aa)
	NOP53	Ribosome biogenesis protein NOP53-like. (461 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1334 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (405 aa)
	ENSTGUP00000031580	annotation not available (272 aa)
	PLEKHA1	Uncharacterized protein. (411 aa)
	CIB1	Calcium and integrin binding 1. (213 aa)
	ENSTGUP00000029281	annotation not available (729 aa)
	PKHD1	Uncharacterized protein. (3650 aa)
	SLC9A3R1	SLC9A3 regulator 1. (333 aa)
	ENSTGUP00000024315	annotation not available (176 aa)
	TSC2	TSC complex subunit 2. (1835 aa)
	PIK3CB	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	MAGI2-2	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1. (136 aa)
	LOC115491418	Growth differentiation factor 11. (377 aa)
	OTUD3	OTU deubiquitinase 3. (376 aa)
	LOC115493455	a_DG1_N2 domain-containing protein. (579 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	MSTN	Myostatin. (375 aa)
	PTPRJ	Uncharacterized protein. (1335 aa)
	SH2B3	SH2B adaptor protein 3. (579 aa)
	INPP5K	IPPc domain-containing protein. (475 aa)
	BANK1	Uncharacterized protein. (823 aa)
	SIRT1	Sirtuin 1. (750 aa)
	EPHA2	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1. (1630 aa)
	LEMD2	LEM domain containing 2. (739 aa)
	PHLDA3	Pleckstrin homology like domain family A member 3. (158 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (473 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FLCN	TSC2	ENSTGUP00000021587	ENSTGUP00000021638	UDENN FLCN/SMCR8-type domain-containing protein.	TSC complex subunit 2.	0.522
MAGI2	MAGI2-2	ENSTGUP00000036432	ENSTGUP00000020459	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1.	0.900
MAGI2-2	MAGI2	ENSTGUP00000020459	ENSTGUP00000036432	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.900
PPARA	SIRT1	ENSTGUP00000012160	ENSTGUP00000003586	Peroxisome proliferator activated receptor alpha.	Sirtuin 1.	0.677
SIRT1	PPARA	ENSTGUP00000003586	ENSTGUP00000012160	Sirtuin 1.	Peroxisome proliferator activated receptor alpha.	0.677
SIRT1	TSC2	ENSTGUP00000003586	ENSTGUP00000021638	Sirtuin 1.	TSC complex subunit 2.	0.561
TSC2	FLCN	ENSTGUP00000021638	ENSTGUP00000021587	TSC complex subunit 2.	UDENN FLCN/SMCR8-type domain-containing protein.	0.522
TSC2	SIRT1	ENSTGUP00000021638	ENSTGUP00000003586	TSC complex subunit 2.	Sirtuin 1.	0.561