STRINGSTRING
SMAD6 SMAD6 TGFBR1 TGFBR1 JAG1 JAG1 PITX2 PITX2 MKS1 MKS1 TGFBR2 TGFBR2 CHD7 CHD7 BMP5 BMP5 BMPR2 BMPR2 WNT11 WNT11 ENSTGUP00000020434 ENSTGUP00000020434 SEMA3C SEMA3C ENSTGUP00000021519 ENSTGUP00000021519 ZFPM1 ZFPM1 CHD8 CHD8 ENG ENG SMO SMO CITED4 CITED4 SMAD7 SMAD7 ZFPM2 ZFPM2 SAV1 SAV1 CCN1 CCN1 TBX20 TBX20 ACVR1 ACVR1 DHRS3 DHRS3 NSD2 NSD2 NKX2-5 NKX2-5 BMP7 BMP7 HAND1 HAND1 TBX3 TBX3 CHD9 CHD9 SMAD4 SMAD4 ENSTGUP00000032655 ENSTGUP00000032655 SLIT3 SLIT3 FGF8 FGF8 NRP2 NRP2 SLIT2 SLIT2 TBX2 TBX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD6SMAD family member 6. (477 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
PITX2Homeobox protein. (360 aa)
MKS1Uncharacterized protein. (570 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
CHD7Chromodomain helicase DNA binding protein 7. (3012 aa)
BMP5Bone morphogenetic protein 5. (453 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
ENSTGUP00000020434annotation not available (505 aa)
SEMA3CUncharacterized protein; Belongs to the semaphorin family. (751 aa)
ENSTGUP00000021519annotation not available (333 aa)
ZFPM1Uncharacterized protein. (1560 aa)
CHD8Chromodomain helicase DNA binding protein 8. (1744 aa)
ENGEndoglin. (631 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (204 aa)
SMAD7MH1 domain-containing protein. (392 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1179 aa)
SAV1Salvador family WW domain containing protein 1. (379 aa)
CCN1Cellular communication network factor 1. (412 aa)
TBX20T-box transcription factor 20. (440 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (647 aa)
DHRS3Dehydrogenase/reductase 3. (324 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1428 aa)
NKX2-5Homeobox domain-containing protein. (329 aa)
BMP7Bone morphogenetic protein 7. (459 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (202 aa)
TBX3T-box transcription factor TBX3. (731 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2890 aa)
SMAD4SMAD family member 4. (514 aa)
ENSTGUP00000032655annotation not available (422 aa)
SLIT3Slit guidance ligand 3. (1516 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (960 aa)
SLIT2Slit guidance ligand 2. (1541 aa)
TBX2TBX domain-containing protein. (653 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.