(26 nodes) Regulation of morphogenesis of a branching structure network (Taeniopygia guttata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LHX1	LIM homeobox 1. (406 aa)
	SIRT6	Sirtuin 6. (348 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
	AR	Androgen receptor. (684 aa)
	SOX9	SRY-box transcription factor 9. (474 aa)
	SIX2	SIX homeobox 2. (287 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (950 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LOC105759937	Uncharacterized protein. (638 aa)
	NTN4	Netrin 4. (615 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (462 aa)
	LHX5	LIM homeobox 5. (420 aa)
	MDK	Midkine. (139 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (621 aa)
	SULF1	Extracellular sulfatase. (1120 aa)
	HOXD13	Homeobox domain-containing protein. (312 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	LRRK2	Leucine rich repeat kinase 2. (2509 aa)
	SIX4	SIX homeobox 4. (749 aa)
	SOX8	SRY-box transcription factor 8. (470 aa)
	GDNF	Glial cell derived neurotrophic factor. (218 aa)
	FKBPL	FKBP prolyl isomerase like. (598 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (744 aa)
	SIX1	Homeobox protein SIX1. (282 aa)
	BTBD7	BTB domain containing 7. (1159 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	MDK	ENSTGUP00000010275	ENSTGUP00000010974	Angiotensinogen; Belongs to the serpin family.	Midkine.	0.410
AR	CTNNB1	ENSTGUP00000002859	ENSTGUP00000004945	Androgen receptor.	Catenin beta 1.	0.882
AR	ESR1	ENSTGUP00000002859	ENSTGUP00000011604	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.728
CTNNB1	AR	ENSTGUP00000004945	ENSTGUP00000002859	Catenin beta 1.	Androgen receptor.	0.882
CTNNB1	ESR1	ENSTGUP00000004945	ENSTGUP00000011604	Catenin beta 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.604
CTNNB1	SMO	ENSTGUP00000004945	ENSTGUP00000001924	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.438
CTNNB1	SOX8	ENSTGUP00000004945	ENSTGUP00000026132	Catenin beta 1.	SRY-box transcription factor 8.	0.581
CTNNB1	SOX9	ENSTGUP00000004945	ENSTGUP00000002966	Catenin beta 1.	SRY-box transcription factor 9.	0.644
ESR1	AR	ENSTGUP00000011604	ENSTGUP00000002859	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Androgen receptor.	0.728
ESR1	CTNNB1	ENSTGUP00000011604	ENSTGUP00000004945	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Catenin beta 1.	0.604
FGF7	GDNF	ENSTGUP00000019495	ENSTGUP00000029452	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Glial cell derived neurotrophic factor.	0.406
FGF7	HGF	ENSTGUP00000019495	ENSTGUP00000002672	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.559
GDNF	FGF7	ENSTGUP00000029452	ENSTGUP00000019495	Glial cell derived neurotrophic factor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
GDNF	HGF	ENSTGUP00000029452	ENSTGUP00000002672	Glial cell derived neurotrophic factor.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.490
GDNF	SMO	ENSTGUP00000029452	ENSTGUP00000001924	Glial cell derived neurotrophic factor.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.506
HGF	FGF7	ENSTGUP00000002672	ENSTGUP00000019495	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.559
HGF	GDNF	ENSTGUP00000002672	ENSTGUP00000029452	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Glial cell derived neurotrophic factor.	0.490
HGF	LGR4	ENSTGUP00000002672	ENSTGUP00000004861	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Leucine rich repeat containing G protein-coupled receptor 4.	0.425
LGR4	HGF	ENSTGUP00000004861	ENSTGUP00000002672	Leucine rich repeat containing G protein-coupled receptor 4.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.425
MDK	AGT	ENSTGUP00000010974	ENSTGUP00000010275	Midkine.	Angiotensinogen; Belongs to the serpin family.	0.410