STRINGSTRING
SIRT4 SIRT4 EGR1 EGR1 FGF1 FGF1 ADCYAP1R1 ADCYAP1R1 PDZD3 PDZD3 SIRT6 SIRT6 STARD4 STARD4 ATCAY ATCAY MFSD2A MFSD2A LOC115492493 LOC115492493 GUCA1B GUCA1B DGKQ DGKQ SLC7A11 SLC7A11 PDK4 PDK4 DAB2 DAB2 MTOR MTOR BRCA1 BRCA1 SOX9 SOX9 C1QTNF1 C1QTNF1 IL1B IL1B ABCD2 ABCD2 SIRT1 SIRT1 SEC14L5 SEC14L5 EIF6 EIF6 SLC27A4 SLC27A4 H6PD H6PD PPARG PPARG SOGA1 SOGA1 DDIT4 DDIT4 GPR50 GPR50 ERLIN2 ERLIN2 NCOR2 NCOR2 MST1 MST1 GNMT GNMT RORA RORA ABCG1 ABCG1 SIRT5 SIRT5 PPTC7 PPTC7 GPLD1 GPLD1 DYRK2 DYRK2 NCOR1 NCOR1 OGT OGT MTNR1A MTNR1A PDK3 PDK3 SREBF1 SREBF1 FOXK1 FOXK1 FH FH PCK1 PCK1 PDK1 PDK1 NOS2 NOS2 LONP2 LONP2 NR1H4 NR1H4 PODN PODN RANBP2 RANBP2 SREBF2 SREBF2 LOC100220316 LOC100220316 EP300 EP300 LEPR LEPR CAV3 CAV3 ACADM ACADM NR1H3 NR1H3 SNAI2 SNAI2 CRY1 CRY1 APPL2 APPL2 CYP7A1 CYP7A1 MAS1 MAS1 ETFBKMT ETFBKMT ACMSD ACMSD PPARA PPARA TSPO TSPO BEND3 BEND3 COQ3 COQ3 H0ZQ02_TAEGU H0ZQ02_TAEGU LACC1 LACC1 LPCAT3 LPCAT3 DUSP12 DUSP12 ZBTB20 ZBTB20 PGP PGP PRMT3 PRMT3 PTH PTH LOC100229817 LOC100229817 FMO4 FMO4 ATPSCKMT ATPSCKMT MIDN MIDN LPGAT1 LPGAT1 LOC115492014 LOC115492014 LOC115490537 LOC115490537 ADORA2B ADORA2B BMP6 BMP6 C1QTNF6 C1QTNF6 FGFR4 FGFR4 HTR2A HTR2A CD74 CD74 ADIPOQ ADIPOQ LHCGR LHCGR MYD88 MYD88 BCKDK BCKDK ARV1 ARV1 H0ZZ90_TAEGU H0ZZ90_TAEGU ENSTGUP00000021519 ENSTGUP00000021519 FLCN FLCN FMO5 FMO5 APOA1 APOA1 GUCA1B-2 GUCA1B-2 PPARD PPARD ABCG4 ABCG4 ZMPSTE24 ZMPSTE24 PTPN2 PTPN2 REST REST LOC100231703 LOC100231703 ENSTGUP00000024522 ENSTGUP00000024522 IGFBP4 IGFBP4 LOC115492493-2 LOC115492493-2 LOC100228336 LOC100228336 ENSTGUP00000025270 ENSTGUP00000025270 SCAP SCAP APOA4 APOA4 FGF19 FGF19 ENSTGUP00000025996 ENSTGUP00000025996 LOC115496245 LOC115496245 TYSND1 TYSND1 RD3 RD3 PSEN1 PSEN1 CAV1 CAV1 LEP LEP SEC14L2 SEC14L2 ENSTGUP00000028351 ENSTGUP00000028351 ENSTGUP00000028883 ENSTGUP00000028883 NCS1 NCS1 FOXK2 FOXK2 KAT2A KAT2A APP APP ENSTGUP00000029481 ENSTGUP00000029481 ATP2B4 ATP2B4 LOC100225533 LOC100225533 CLYBL CLYBL NR1D1 NR1D1 CDA CDA SLC35B4 SLC35B4 PDXP PDXP GUCA1C GUCA1C ENSTGUP00000032175 ENSTGUP00000032175 PIBF1 PIBF1 ENSTGUP00000032655 ENSTGUP00000032655 WDTC1 WDTC1 PMAIP1 PMAIP1 MLYCD MLYCD ENSTGUP00000033254 ENSTGUP00000033254 TTC39A TTC39A PID1 PID1 PRKAA1 PRKAA1 TIGAR TIGAR FAM3C FAM3C JMJD8 JMJD8 FABP5 FABP5 LCMT1 LCMT1 PPARGC1A PPARGC1A NKX1-1 NKX1-1 KAT2B KAT2B COX11 COX11 TSPO2 TSPO2 ERLIN1 ERLIN1 SLC45A3 SLC45A3 TTC39B TTC39B LOC115492668 LOC115492668 LOC100229618 LOC100229618 DNM1L DNM1L FMO1 FMO1 ANXA1 ANXA1 DNAJC30 DNAJC30
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT4NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (517 aa)
PDZD3PDZ domain containing 3. (434 aa)
SIRT6Sirtuin 6. (348 aa)
STARD4StAR related lipid transfer domain containing 4. (216 aa)
ATCAYATCAY kinesin light chain interacting caytaxin. (440 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (720 aa)
LOC115492493Uncharacterized protein. (199 aa)
GUCA1BGuanylate cyclase activator 1B. (198 aa)
DGKQDiacylglycerol kinase. (938 aa)
SLC7A11Solute carrier family 7 member 11. (503 aa)
PDK4Protein-serine/threonine kinase. (419 aa)
DAB2DAB adaptor protein 2. (716 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (1322 aa)
BRCA1Uncharacterized protein. (1803 aa)
SOX9SRY-box transcription factor 9. (474 aa)
C1QTNF1Uncharacterized protein. (276 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (299 aa)
ABCD2ATP binding cassette subfamily D member 2. (734 aa)
SIRT1Sirtuin 1. (750 aa)
SEC14L5SEC14 like lipid binding 5. (707 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (337 aa)
SLC27A4Solute carrier family 27 member 4. (631 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (790 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (473 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1715 aa)
DDIT4DNA damage inducible transcript 4. (192 aa)
GPR50G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa)
ERLIN2ER lipid raft associated 2. (444 aa)
NCOR2Nuclear receptor corepressor 2. (2480 aa)
MST1Macrophage stimulating 1. (705 aa)
GNMTGlycine N-methyltransferase. (173 aa)
RORARAR related orphan receptor A. (468 aa)
ABCG1ABC transporter domain-containing protein. (666 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (310 aa)
PPTC7Protein phosphatase; Belongs to the PP2C family. (297 aa)
GPLD1Zn_dep_PLPC domain-containing protein. (834 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (597 aa)
NCOR1Nuclear receptor corepressor 1. (2533 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa)
MTNR1AMel-1a melatonin receptor; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PDK3Protein-serine/threonine kinase. (406 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1120 aa)
FOXK1Forkhead box K1. (657 aa)
FHFumarate hydratase. (509 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PDK1Protein-serine/threonine kinase. (408 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1145 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. (851 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (473 aa)
PODNPodocan. (553 aa)
RANBP2RAN binding protein 2. (2969 aa)
SREBF2BHLH domain-containing protein. (1088 aa)
LOC100220316Adenylate kinase 4, mitochondrial. (244 aa)
EP300E1A binding protein p300. (2445 aa)
LEPRUncharacterized protein. (1135 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ACADMGeranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (730 aa)
NR1H3Uncharacterized protein. (418 aa)
SNAI2Uncharacterized protein. (268 aa)
CRY1Cryptochrome circadian regulator 1. (620 aa)
APPL2Uncharacterized protein. (658 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa)
ETFBKMTUncharacterized protein. (271 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
TSPOTranslocator protein. (167 aa)
BEND3BEN domain containing 3. (842 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (346 aa)
H0ZQ02_TAEGUUncharacterized protein. (480 aa)
LACC1Uncharacterized protein. (438 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (469 aa)
DUSP12Dual specificity phosphatase 12. (312 aa)
ZBTB20Zinc finger and BTB domain containing 20. (756 aa)
PGPPhosphoglycolate phosphatase. (318 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (530 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
LOC100229817Uncharacterized protein. (423 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (546 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (229 aa)
MIDNMidnolin. (743 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
LOC115492014ADP-ribosylation factor-like protein 2. (184 aa)
LOC115490537Leptin receptor-like. (1122 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (348 aa)
BMP6Bone morphogenetic protein 6. (414 aa)
C1QTNF6C1q and TNF related 6. (319 aa)
FGFR4Fibroblast growth factor receptor. (865 aa)
HTR2A5-hydroxytryptamine receptor 2A. (503 aa)
CD74Uncharacterized protein. (289 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (718 aa)
MYD88MYD88 innate immune signal transduction adaptor. (557 aa)
BCKDKBranched chain keto acid dehydrogenase kinase. (451 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (234 aa)
H0ZZ90_TAEGUUncharacterized protein. (505 aa)
ENSTGUP00000021519annotation not available (333 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (719 aa)
APOA1Uncharacterized protein. (264 aa)
GUCA1B-2Guanylyl cyclase-activating protein 2. (198 aa)
PPARDUncharacterized protein. (449 aa)
ABCG4ATP-binding cassette, subfamily G (WHITE), member 4. (817 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (469 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (420 aa)
RESTRE1 silencing transcription factor. (893 aa)
LOC100231703Photolyase/cryptochrome alpha/beta domain-containing protein. (595 aa)
ENSTGUP00000024522annotation not available (197 aa)
IGFBP4Insulin like growth factor binding protein 4. (333 aa)
LOC115492493-2Guanylyl cyclase-activating protein 1. (199 aa)
LOC100228336Guanylin. (109 aa)
ENSTGUP00000025270annotation not available (434 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein isoform X1. (1283 aa)
APOA4Apolipoprotein A-IV isoform X1. (367 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
ENSTGUP00000025996annotation not available (189 aa)
LOC115496245GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (251 aa)
TYSND1Peroxisomal leader peptide-processing protease. (516 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (234 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LEPTaeniopygia guttata leptin (LEP), mRNA. (168 aa)
SEC14L2SEC14 like lipid binding 2. (403 aa)
ENSTGUP00000028351annotation not available (712 aa)
ENSTGUP00000028883annotation not available (59 aa)
NCS1Putative frequenin. (411 aa)
FOXK2Forkhead box K2. (783 aa)
KAT2ALysine acetyltransferase 2A. (833 aa)
APPAmyloid beta precursor protein. (797 aa)
ENSTGUP00000029481annotation not available (483 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1338 aa)
LOC100225533Uncharacterized protein. (188 aa)
CLYBLHpcH_HpaI domain-containing protein. (336 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (553 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa)
SLC35B4Uncharacterized protein. (344 aa)
PDXPPyridoxal phosphate phosphatase. (415 aa)
GUCA1CUncharacterized protein. (240 aa)
ENSTGUP00000032175annotation not available (183 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (793 aa)
ENSTGUP00000032655annotation not available (422 aa)
WDTC1WD and tetratricopeptide repeats 1. (827 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (78 aa)
MLYCDMalonyl-CoA decarboxylase. (544 aa)
ENSTGUP00000033254annotation not available (279 aa)
TTC39ATetratricopeptide repeat domain 39A. (575 aa)
PID1Phosphotyrosine interaction domain containing 1. (217 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
TIGARUncharacterized protein. (284 aa)
FAM3CILEI domain-containing protein. (227 aa)
JMJD8Jumonji domain containing 8. (477 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (185 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (339 aa)
PPARGC1APPARG coactivator 1 alpha. (807 aa)
NKX1-1NK1 homeobox 1. (391 aa)
KAT2BLysine acetyltransferase 2B. (810 aa)
COX11Uncharacterized protein. (331 aa)
TSPO2Translocator protein 2. (164 aa)
ERLIN1PHB domain-containing protein. (347 aa)
SLC45A3Solute carrier family 45 member 3. (572 aa)
TTC39BTetratricopeptide repeat domain 39B. (586 aa)
LOC115492668Medium-chain specific acyl-CoA dehydrogenase, mitochondrial. (422 aa)
LOC100229618Alpha-1-antiproteinase-like isoform X1. (445 aa)
DNM1LUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
FMO1Flavin-containing monooxygenase. (530 aa)
ANXA1Annexin. (364 aa)
DNAJC30DnaJ homolog subfamily C member 30, mitochondrial. (222 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
Server load: low (24%) [HD]