(17 nodes) Triglyceride homeostasis network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ABCG8	ATP binding cassette subfamily G member 8. (678 aa)
	SIRT1	Sirtuin 1. (750 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (505 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (525 aa)
	PNPLA8	Patatin like phospholipase domain containing 8. (742 aa)
	LIPC	Lipase C, hepatic type. (499 aa)
	MED13	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2179 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (473 aa)
	ANGPTL3	Fibrinogen C-terminal domain-containing protein. (459 aa)
	ANGPTL4	Angiopoietin like 4. (659 aa)
	APOA1	Uncharacterized protein. (264 aa)
	PLA2G12B	Phospholipase A2 group XIIB. (202 aa)
	ENSTGUP00000028883	annotation not available (59 aa)
	FITM2	Fat storage inducing transmembrane protein 2. (271 aa)
	XBP1	X-box binding protein 1. (260 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (641 aa)
	FUNDC2	FUN14 domain containing 2. (276 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG5	ABCG8	ENSTGUP00000036826	ENSTGUP00000037476	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.998
ABCG5	APOA1	ENSTGUP00000036826	ENSTGUP00000022325	ATP binding cassette subfamily G member 5.	Uncharacterized protein.	0.557
ABCG5	NR1H4	ENSTGUP00000036826	ENSTGUP00000009262	ATP binding cassette subfamily G member 5.	Nuclear receptor subfamily 1 group H member 4.	0.589
ABCG8	ABCG5	ENSTGUP00000037476	ENSTGUP00000036826	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.998
ABCG8	APOA1	ENSTGUP00000037476	ENSTGUP00000022325	ATP binding cassette subfamily G member 8.	Uncharacterized protein.	0.526
ABCG8	NR1H4	ENSTGUP00000037476	ENSTGUP00000009262	ATP binding cassette subfamily G member 8.	Nuclear receptor subfamily 1 group H member 4.	0.536
APOA1	ABCG5	ENSTGUP00000022325	ENSTGUP00000036826	Uncharacterized protein.	ATP binding cassette subfamily G member 5.	0.557
APOA1	ABCG8	ENSTGUP00000022325	ENSTGUP00000037476	Uncharacterized protein.	ATP binding cassette subfamily G member 8.	0.526
APOA1	CETP	ENSTGUP00000022325	ENSTGUP00000005255	Uncharacterized protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.909
APOA1	LIPC	ENSTGUP00000022325	ENSTGUP00000006311	Uncharacterized protein.	Lipase C, hepatic type.	0.679
APOA1	PLA2G12B	ENSTGUP00000022325	ENSTGUP00000022662	Uncharacterized protein.	Phospholipase A2 group XIIB.	0.609
APOA1	SCARB1	ENSTGUP00000022325	ENSTGUP00000005161	Uncharacterized protein.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.875
CETP	APOA1	ENSTGUP00000005255	ENSTGUP00000022325	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Uncharacterized protein.	0.909
CETP	LIPC	ENSTGUP00000005255	ENSTGUP00000006311	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Lipase C, hepatic type.	0.698
CETP	SCARB1	ENSTGUP00000005255	ENSTGUP00000005161	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.422
LIPC	APOA1	ENSTGUP00000006311	ENSTGUP00000022325	Lipase C, hepatic type.	Uncharacterized protein.	0.679
LIPC	CETP	ENSTGUP00000006311	ENSTGUP00000005255	Lipase C, hepatic type.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.698
NR1H4	ABCG5	ENSTGUP00000009262	ENSTGUP00000036826	Nuclear receptor subfamily 1 group H member 4.	ATP binding cassette subfamily G member 5.	0.589
NR1H4	ABCG8	ENSTGUP00000009262	ENSTGUP00000037476	Nuclear receptor subfamily 1 group H member 4.	ATP binding cassette subfamily G member 8.	0.536
PLA2G12B	APOA1	ENSTGUP00000022662	ENSTGUP00000022325	Phospholipase A2 group XIIB.	Uncharacterized protein.	0.609