STRINGSTRING
ENSTGUP00000031619 ENSTGUP00000031619 DDR2 DDR2 SMAD4 SMAD4 ENSTGUP00000032655 ENSTGUP00000032655 PMAIP1 PMAIP1 ENSTGUP00000033254 ENSTGUP00000033254 LOC105760891 LOC105760891 PINK1 PINK1 SUV39H1 SUV39H1 PICK1 PICK1 BACH1 BACH1 ATP6V1A ATP6V1A FAM167A FAM167A ADAM17 ADAM17 HIF1A HIF1A GUCY1A2 GUCY1A2 MYC MYC FOXO3 FOXO3 FOXO1 FOXO1 SCFD1 SCFD1 AQP1 AQP1 TIGAR TIGAR CCDC115 CCDC115 ENSTGUP00000033975 ENSTGUP00000033975 ENSTGUP00000034340 ENSTGUP00000034340 NARF NARF LOC100225337 LOC100225337 ENSTGUP00000034670 ENSTGUP00000034670 ENSTGUP00000034861 ENSTGUP00000034861 PIN1 PIN1 VHL VHL RBPJ RBPJ NOP53 NOP53 STOX1 STOX1 PLAT PLAT P2RX3 P2RX3 NFE2L2 NFE2L2 HP1BP3 HP1BP3 LOXL3 LOXL3 ARNT ARNT AIFM1 AIFM1 TGFB3 TGFB3 TGFB2 TGFB2 WDR83 WDR83 WTIP WTIP ENSTGUP00000031243 ENSTGUP00000031243 TMEM199 TMEM199 LOC100228395 LOC100228395 EDN1 EDN1 MYOCD MYOCD GUCY1A1 GUCY1A1 TSC1 TSC1 SRF SRF DDIT4 DDIT4 ATP6AP1 ATP6AP1 PLEKHN1 PLEKHN1 TGFBR2 TGFBR2 SIRT1 SIRT1 NPEPPS NPEPPS LOC100231082 LOC100231082 EDNRA EDNRA SUV39H2 SUV39H2 MTOR MTOR NDNF NDNF SLC9A1 SLC9A1 OPRD1 OPRD1 PAM PAM CITED4 CITED4 CRYAB CRYAB HYOU1 HYOU1 LONP1 LONP1 EGR1 EGR1 GUCY1B1 GUCY1B1 ATP6V1G1 ATP6V1G1 PGF PGF EGLN3 EGLN3 NDRG1 NDRG1 ENSTGUP00000018634 ENSTGUP00000018634 ENSTGUP00000020053 ENSTGUP00000020053 ENSTGUP00000020418 ENSTGUP00000020418 ENSTGUP00000020434 ENSTGUP00000020434 BNIP3 BNIP3 CYGB CYGB ENSTGUP00000021498 ENSTGUP00000021498 ENSTGUP00000021519 ENSTGUP00000021519 LIMD1 LIMD1 ADO ADO FAS FAS TM9SF4 TM9SF4 FAM162A FAM162A PPARD PPARD ENSTGUP00000023270 ENSTGUP00000023270 MDM4 MDM4 REST REST TERT TERT ENSTGUP00000024216 ENSTGUP00000024216 ENSTGUP00000024337 ENSTGUP00000024337 EEF2K EEF2K ENSTGUP00000024522 ENSTGUP00000024522 NGB NGB SCAP SCAP FUNDC1 FUNDC1 LOC115496245 LOC115496245 CIAO3 CIAO3 ENSTGUP00000026806 ENSTGUP00000026806 LOC100231082-2 LOC100231082-2 NDUFS2 NDUFS2 LOC100219522 LOC100219522 CAV1 CAV1 CPEB1 CPEB1 CHRNB2 CHRNB2 FABP1 FABP1 EPAS1 EPAS1 ENSTGUP00000029110 ENSTGUP00000029110 KCNK2 KCNK2 LOC100221863 LOC100221863 FNDC1 FNDC1 LOC100217613 LOC100217613 HSP90B1 HSP90B1 MB MB TXN2 TXN2 CAV3 CAV3 ATF4 ATF4 EGLN1 EGLN1 EP300 EP300 LOC100220316 LOC100220316 CPEB2 CPEB2 TH TH MYOD1 MYOD1 NOS2 NOS2 TXNRD2 TXNRD2 VEGFD VEGFD ARNT2 ARNT2 SLC7A5 SLC7A5 HIF1AN HIF1AN MMP2 MMP2 ALKBH5 ALKBH5 PDK3 PDK3 H0Z8Z3_TAEGU H0Z8Z3_TAEGU VEGFC VEGFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSTGUP00000031619annotation not available (271 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (1179 aa)
SMAD4SMAD family member 4. (514 aa)
ENSTGUP00000032655annotation not available (422 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (78 aa)
ENSTGUP00000033254annotation not available (279 aa)
LOC105760891Cytosolic iron-sulfur assembly component 3 isoform X1. (475 aa)
PINK1PTEN induced kinase 1. (515 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (353 aa)
PICK1Uncharacterized protein. (435 aa)
BACH1BTB domain and CNC homolog 1. (766 aa)
ATP6V1AUncharacterized protein. (668 aa)
FAM167AFamily with sequence similarity 167 member A. (172 aa)
ADAM17ADAM metallopeptidase domain 17. (918 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (716 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
FOXO3Fork-head domain-containing protein. (663 aa)
FOXO1Forkhead box O1. (785 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (632 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
TIGARUncharacterized protein. (284 aa)
CCDC115Coiled-coil domain-containing protein 115 isoform X1. (211 aa)
ENSTGUP00000033975annotation not available (497 aa)
ENSTGUP00000034340V-type proton ATPase catalytic subunit A. (613 aa)
NARFFe_hyd_SSU domain-containing protein; Belongs to the NARF family. (496 aa)
LOC100225337Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (787 aa)
ENSTGUP00000034670annotation not available (523 aa)
ENSTGUP00000034861annotation not available (675 aa)
PIN1Peptidylprolyl cis/trans isomerase, NIMA-interacting 1. (156 aa)
VHLUncharacterized protein. (166 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (508 aa)
NOP53Ribosome biogenesis protein NOP53-like. (461 aa)
STOX1Stork_head domain-containing protein. (850 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (558 aa)
P2RX3Purinergic receptor P2X 3. (774 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (623 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (557 aa)
LOXL3Lysyl oxidase like 3. (772 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (785 aa)
AIFM1Uncharacterized protein. (593 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (533 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (433 aa)
WDR83WD repeat domain 83. (316 aa)
WTIPWilms tumor protein 1-interacting protein isoform X1. (615 aa)
ENSTGUP00000031243annotation not available (686 aa)
TMEM199Transmembrane protein 199. (432 aa)
LOC100228395Uncharacterized protein. (502 aa)
EDN1Endothelin 1. (202 aa)
MYOCDMyocardin. (875 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
TSC1Uncharacterized protein. (1175 aa)
SRFSerum response factor. (485 aa)
DDIT4DNA damage inducible transcript 4. (192 aa)
ATP6AP1Uncharacterized protein. (458 aa)
PLEKHN1PH domain-containing protein. (847 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
SIRT1Sirtuin 1. (750 aa)
NPEPPSAminopeptidase. (830 aa)
LOC100231082Uncharacterized protein. (873 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (404 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (1322 aa)
NDNFNeuron derived neurotrophic factor. (589 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (803 aa)
OPRD1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (382 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (914 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (204 aa)
CRYABCrystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (174 aa)
HYOU1Hypoxia up-regulated 1. (903 aa)
LONP1Uncharacterized protein. (937 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
GUCY1B1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa)
ATP6V1G1V-type H+-transporting ATPase subunit G. (133 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (255 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (432 aa)
NDRG1N-myc downstream regulated 1. (402 aa)
ENSTGUP00000018634annotation not available (359 aa)
ENSTGUP00000020053annotation not available (495 aa)
ENSTGUP00000020418annotation not available (134 aa)
ENSTGUP00000020434annotation not available (505 aa)
BNIP3BCL2 interacting protein 3. (275 aa)
CYGBCytoglobin; Belongs to the globin family. (276 aa)
ENSTGUP00000021498annotation not available (382 aa)
ENSTGUP00000021519annotation not available (333 aa)
LIMD1LIM domains containing 1. (588 aa)
ADO2-aminoethanethiol dioxygenase. (222 aa)
FASUncharacterized protein. (363 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (667 aa)
FAM162AProtein FAM162A. (173 aa)
PPARDUncharacterized protein. (449 aa)
ENSTGUP00000023270annotation not available (573 aa)
MDM4MDM4 regulator of p53. (471 aa)
RESTRE1 silencing transcription factor. (893 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1343 aa)
ENSTGUP00000024216annotation not available (311 aa)
ENSTGUP00000024337annotation not available (242 aa)
EEF2KEukaryotic elongation factor 2 kinase. (736 aa)
ENSTGUP00000024522annotation not available (197 aa)
NGBNeuroglobin; Belongs to the globin family. (161 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein isoform X1. (1283 aa)
FUNDC1FUN14 domain containing 1. (167 aa)
LOC115496245GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (251 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (475 aa)
ENSTGUP00000026806annotation not available (421 aa)
LOC100231082-2Discoidin domain-containing receptor 2-like. (873 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial. (703 aa)
LOC100219522NAD-dependent protein deacetylase sirtuin-2-like. (455 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CPEB1Uncharacterized protein. (590 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (706 aa)
FABP1FABP domain-containing protein. (184 aa)
EPAS1Endothelial PAS domain protein 1. (866 aa)
ENSTGUP00000029110annotation not available (193 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (422 aa)
LOC100221863Uncharacterized protein. (511 aa)
FNDC1Fibronectin type III domain containing 1. (1083 aa)
LOC100217613BH4_AAA_HYDROXYL_2 domain-containing protein. (459 aa)
HSP90B1HATPase_c domain-containing protein. (794 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
TXN2Putative thioredoxin 2 variant 3. (158 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ATF4Activating transcription factor 4. (354 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (434 aa)
EP300E1A binding protein p300. (2445 aa)
LOC100220316Adenylate kinase 4, mitochondrial. (244 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (833 aa)
THTyrosine hydroxylase. (491 aa)
MYOD1Myogenic factor. (294 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1145 aa)
TXNRD2Thioredoxin reductase 2. (480 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (770 aa)
SLC7A5Solute carrier family 7 member 5. (522 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (393 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (383 aa)
PDK3Protein-serine/threonine kinase. (406 aa)
H0Z8Z3_TAEGUUncharacterized protein; Belongs to the peptidase S9B family. (672 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (468 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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