(56 nodes) Positive regulation of canonical Wnt signaling pathway network (Taeniopygia guttata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	TTC21B	Tetratricopeptide repeat domain 21B. (1283 aa)
	CSNK1D	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (415 aa)
	TBL1X	Uncharacterized protein. (557 aa)
	PIN1	Peptidylprolyl cis/trans isomerase, NIMA-interacting 1. (156 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (506 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3513 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (117 aa)
	BAMBI	BMP and activin membrane bound inhibitor. (261 aa)
	TMEM9	Transmembrane protein 9. (264 aa)
	RSPO1	R-spondin 1. (258 aa)
	DLX5	Distal-less homeobox 5. (290 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (239 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
	CSNK1G1	Casein kinase 1 gamma 1. (464 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (950 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1266 aa)
	PRDM15	PR/SET domain 15. (1183 aa)
	TMEM198	Transmembrane protein 198. (402 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (360 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (963 aa)
	NLE1	Notchless homolog 1. (509 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (910 aa)
	RNF220	Ring finger protein 220. (591 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (508 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1168 aa)
	LRRK1	Leucine rich repeat kinase 1. (1998 aa)
	LOC100225657	Wnt ligand secretion mediator. (541 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	GPC5	Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (300 aa)
	RSPO3	R-spondin 3. (275 aa)
	LYPD6	LY6/PLAUR domain containing 6. (185 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2801 aa)
	USP47	USP domain-containing protein; Belongs to the peptidase C19 family. (1447 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	LRRK2	Leucine rich repeat kinase 2. (2509 aa)
	ENSTGUP00000022179	annotation not available (345 aa)
	AMER1	Uncharacterized protein. (1144 aa)
	CSNK1G3	Protein kinase domain-containing protein. (451 aa)
	DKK2	Dickkopf_N domain-containing protein. (269 aa)
	RNF146	Ring finger protein 146. (347 aa)
	ILK	Integrin linked kinase. (676 aa)
	WNK2	WNK lysine deficient protein kinase 2. (2249 aa)
	XIAP	X-linked inhibitor of apoptosis. (495 aa)
	FAM53B	Family with sequence similarity 53 member B. (465 aa)
	USP8	Uncharacterized protein; Belongs to the peptidase C19 family. (1115 aa)
	GID8	GID complex subunit 8 homolog. (228 aa)
	CAPRIN2	C1q domain-containing protein. (1187 aa)
	RPS12	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (277 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (1079 aa)
	LOC100218614	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1084 aa)
	CSNK1E	Protein kinase domain-containing protein. (482 aa)
	LOC100225657-2	Protein wntless homolog. (541 aa)
	CSNK1G2	Casein kinase 1 gamma 2. (450 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	TMEM198	ENSTGUP00000023391	ENSTGUP00000006367	Uncharacterized protein.	Transmembrane protein 198.	0.487
AMER1	WNT3A	ENSTGUP00000023391	ENSTGUP00000019039	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411
CAV1	CAV3	ENSTGUP00000027745	ENSTGUP00000010724	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV1	WNT3A	ENSTGUP00000027745	ENSTGUP00000019039	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.549
CAV3	CAV1	ENSTGUP00000010724	ENSTGUP00000027745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV3	WNT3A	ENSTGUP00000010724	ENSTGUP00000019039	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.593
CSNK1D	RPS12	ENSTGUP00000038100	ENSTGUP00000029629	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.	0.633
CSNK1E	RPS12	ENSTGUP00000025663	ENSTGUP00000029629	Protein kinase domain-containing protein.	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.	0.633
DAAM1	DAAM2	ENSTGUP00000029241	ENSTGUP00000025966	Dishevelled associated activator of morphogenesis 1.	Dishevelled associated activator of morphogenesis 2.	0.901
DAAM2	DAAM1	ENSTGUP00000025966	ENSTGUP00000029241	Dishevelled associated activator of morphogenesis 2.	Dishevelled associated activator of morphogenesis 1.	0.901
DKK2	RSPO3	ENSTGUP00000024425	ENSTGUP00000012128	Dickkopf_N domain-containing protein.	R-spondin 3.	0.416
LGR4	LGR5	ENSTGUP00000004861	ENSTGUP00000007410	Leucine rich repeat containing G protein-coupled receptor 4.	Leucine rich repeat containing G protein-coupled receptor 5.	0.968
LGR4	RSPO1	ENSTGUP00000004861	ENSTGUP00000001588	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 1.	0.999
LGR4	RSPO3	ENSTGUP00000004861	ENSTGUP00000012128	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 3.	0.984
LGR5	LGR4	ENSTGUP00000007410	ENSTGUP00000004861	Leucine rich repeat containing G protein-coupled receptor 5.	Leucine rich repeat containing G protein-coupled receptor 4.	0.968
LGR5	RSPO1	ENSTGUP00000007410	ENSTGUP00000001588	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 1.	0.995
LGR5	RSPO3	ENSTGUP00000007410	ENSTGUP00000012128	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 3.	0.980
LOC100225657	WNT3A	ENSTGUP00000010544	ENSTGUP00000019039	Wnt ligand secretion mediator.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.769
LOC100225657-2	WNT3A	ENSTGUP00000024829	ENSTGUP00000019039	Protein wntless homolog.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.769
RNF146	TNKS	ENSTGUP00000033288	ENSTGUP00000005031	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.940