(121 nodes) Regulation of plasma membrane bounded cell projection assembly network (Taeniopygia guttata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSTGUP00000021025	annotation not available (174 aa)
	IFT88	Uncharacterized protein. (826 aa)
	SDCCAG8	Uncharacterized protein. (745 aa)
	LOC115491418	Growth differentiation factor 11. (377 aa)
	ENSTGUP00000020077	annotation not available (435 aa)
	EVL	WH1 domain-containing protein. (423 aa)
	ABI3	ABI gene family member 3 isoform X1. (430 aa)
	ENSTGUP00000017345	annotation not available (744 aa)
	LOC115490575	Bridging integrator 3-like. (207 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (142 aa)
	SYNE2	KASH domain-containing protein. (7018 aa)
	H0ZR88_TAEGU	Uncharacterized protein. (743 aa)
	KLF5	Kruppel like factor 5. (445 aa)
	PLEK2	Pleckstrin 2. (355 aa)
	CLRN1	Clarin 1. (232 aa)
	MSTN	Myostatin. (375 aa)
	FXR1	FMR1 autosomal homolog 1. (677 aa)
	HRG	Uncharacterized protein. (626 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	SLIT2	Slit guidance ligand 2. (1541 aa)
	IFT20	Uncharacterized protein. (132 aa)
	ABITRAM	Actin binding transcription modulator. (203 aa)
	CDK10	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (381 aa)
	CDKL5	Cyclin dependent kinase like 5. (990 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
	H0ZAP7_TAEGU	Uncharacterized protein. (551 aa)
	MYO10	Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2060 aa)
	EPS8L2	EPS8 like 2. (736 aa)
	LOC100226244	Uncharacterized protein. (191 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
	C15orf62	Chromosome 15 open reading frame 62. (265 aa)
	GPM6A	Glycoprotein M6A. (278 aa)
	ODF2L	Uncharacterized protein. (611 aa)
	ENTR1	Uncharacterized protein. (99 aa)
	TESK1	Testis associated actin remodelling kinase 1. (692 aa)
	ACTR2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (407 aa)
	LOC105759042	Protein kinase domain-containing protein. (559 aa)
	TENM1	Teneurin transmembrane protein 1. (2713 aa)
	PALM	Paralemmin. (418 aa)
	SYNE1	Spectrin repeat containing nuclear envelope protein 1. (2828 aa)
	H1A1Z5_TAEGU	Uncharacterized protein. (761 aa)
	SH3YL1	SH3 and SYLF domain containing 1. (397 aa)
	LOC100225382	Uncharacterized protein. (1621 aa)
	PODXL	Uncharacterized protein. (602 aa)
	ENSTGUP00000024315	annotation not available (176 aa)
	CDC42EP1	CDC42 effector protein 1. (412 aa)
	COBL	Uncharacterized protein. (1393 aa)
	ANLN	Anillin actin binding protein. (1285 aa)
	HTT	Uncharacterized protein. (3107 aa)
	ARHGAP24	Rho GTPase activating protein 24. (747 aa)
	FAM98A	Family with sequence similarity 98 member A. (571 aa)
	LOC100224661	Uncharacterized protein. (444 aa)
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (277 aa)
	MYO3B	Myosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1231 aa)
	RCC2	Protein RCC2. (1203 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	ENSTGUP00000027764	annotation not available (358 aa)
	WASL	WASP like actin nucleation promoting factor. (507 aa)
	ENSTGUP00000028627	annotation not available (369 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (914 aa)
	ENSTGUP00000029281	annotation not available (729 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (836 aa)
	CCL19	C-C motif chemokine ligand 19. (152 aa)
	ENSTGUP00000030506	annotation not available (469 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (763 aa)
	H0Z7S6_TAEGU	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2037 aa)
	TAPT1	Transmembrane anterior posterior transformation 1. (600 aa)
	CEP97	Uncharacterized protein. (862 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ENSTGUP00000032088	annotation not available (1434 aa)
	TENM2	Tox-GHH domain-containing protein. (2763 aa)
	BRK1	Chromosome 3 open reading frame 10. (176 aa)
	ENSTGUP00000033254	annotation not available (279 aa)
	ENSTGUP00000033523	annotation not available (393 aa)
	FNBP1L	Formin binding protein 1 like. (605 aa)
	CDC42EP3	CDC42 effector protein 3. (255 aa)
	BIN3	Bridging integrator 3. (319 aa)
	NDEL1	NudE neurodevelopment protein 1 like 1. (356 aa)
	RIPOR2	PL48 domain-containing protein. (1132 aa)
	LOC115494026	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1. (786 aa)
	MIEN1	Taeniopygia guttata migration and invasion enhancer 1 (MIEN1), mRNA. (302 aa)
	MAP4	Uncharacterized protein. (1103 aa)
	CEP120	Centrosomal protein 120. (1009 aa)
	CDC42	Cell division cycle 42. (302 aa)
	BBS4	Bardet-Biedl syndrome 4. (565 aa)
	ENSTGUP00000036780	annotation not available (1050 aa)
	FMR1	Fragile X mental retardation 1. (548 aa)
	MPHOSPH9	Uncharacterized protein. (1104 aa)
	BCAS3	BCAS3 microtubule associated cell migration factor. (946 aa)
	IFT140	Intraflagellar transport 140. (1476 aa)
	AGRN	Agrin. (2076 aa)
	EPS8L3	EPS8 like 3. (521 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (736 aa)
	LOC100221351	C-C motif chemokine 16. (127 aa)
	CCP110	Centriolar coiled-coil protein 110. (1026 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1292 aa)
	DEF8	Differentially expressed in FDCP 8 homolog. (671 aa)
	TBC1D30	TBC1 domain family member 30. (847 aa)
	PLCE1	Phosphoinositide phospholipase C. (2331 aa)
	CDC42EP4	CDC42 effector protein 4. (317 aa)
	ATMIN	ATM interactor. (789 aa)
	WASF2	WASP family member 2. (500 aa)
	MYO3A	Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1649 aa)
	KIF24	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1329 aa)
	H0YUH5_TAEGU	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1052 aa)
	EPHA2	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (718 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (1322 aa)
	H0YW59_TAEGU	Uncharacterized protein. (246 aa)
	WRAP73	WD repeat containing, antisense to TP73. (447 aa)
	FRMD7	FERM domain containing 7. (702 aa)
	PLEKHM1	Uncharacterized protein. (1031 aa)
	DYNC2LI1	Dynein cytoplasmic 2 light intermediate chain 1. (355 aa)
	ODF2	Uncharacterized protein. (821 aa)
	TWF2	Twinfilin actin binding protein 2. (415 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1541 aa)
	TWF1	Twinfilin actin binding protein 1. (434 aa)
	TBC1D7	Rab-GAP TBC domain-containing protein. (293 aa)
	SRF	Serum response factor. (485 aa)
	ZMYND10	Zinc finger MYND-type containing 10. (447 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI3	ACTR2	ENSTGUP00000019355	ENSTGUP00000021594	ABI gene family member 3 isoform X1.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.635
ABI3	BRK1	ENSTGUP00000019355	ENSTGUP00000032771	ABI gene family member 3 isoform X1.	Chromosome 3 open reading frame 10.	0.891
ABI3	CYFIP1	ENSTGUP00000019355	ENSTGUP00000038181	ABI gene family member 3 isoform X1.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.870
ABI3	DEF8	ENSTGUP00000019355	ENSTGUP00000038214	ABI gene family member 3 isoform X1.	Differentially expressed in FDCP 8 homolog.	0.439
ABI3	ENSTGUP00000028627	ENSTGUP00000019355	ENSTGUP00000028627	ABI gene family member 3 isoform X1.	annotation not available	0.494
ABI3	ENSTGUP00000030506	ENSTGUP00000019355	ENSTGUP00000030506	ABI gene family member 3 isoform X1.	annotation not available	0.494
ABI3	WASF2	ENSTGUP00000019355	ENSTGUP00000000989	ABI gene family member 3 isoform X1.	WASP family member 2.	0.743
ABI3	WASL	ENSTGUP00000019355	ENSTGUP00000028587	ABI gene family member 3 isoform X1.	WASP like actin nucleation promoting factor.	0.494
ACTR2	ABI3	ENSTGUP00000021594	ENSTGUP00000019355	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	ABI gene family member 3 isoform X1.	0.635
ACTR2	ARF6	ENSTGUP00000021594	ENSTGUP00000013587	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.400
ACTR2	BRK1	ENSTGUP00000021594	ENSTGUP00000032771	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Chromosome 3 open reading frame 10.	0.849
ACTR2	CAPZB	ENSTGUP00000021594	ENSTGUP00000026302	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.665
ACTR2	CDC42	ENSTGUP00000021594	ENSTGUP00000036310	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Cell division cycle 42.	0.811
ACTR2	CYFIP1	ENSTGUP00000021594	ENSTGUP00000038181	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.779
ACTR2	ENSTGUP00000028627	ENSTGUP00000021594	ENSTGUP00000028627	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	annotation not available	0.883
ACTR2	ENSTGUP00000030506	ENSTGUP00000021594	ENSTGUP00000030506	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	annotation not available	0.883
ACTR2	FNBP1L	ENSTGUP00000021594	ENSTGUP00000033824	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Formin binding protein 1 like.	0.490
ACTR2	H0Z7S6_TAEGU	ENSTGUP00000021594	ENSTGUP00000030975	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.446
ACTR2	LOC100226244	ENSTGUP00000021594	ENSTGUP00000007228	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Uncharacterized protein.	0.566
ACTR2	MYO10	ENSTGUP00000021594	ENSTGUP00000007574	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.446