(139 nodes) Regulation of leukocyte differentiation network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSF1	Macrophage colony-stimulating factor 1 precursor. (498 aa)
	TBX21	T-box transcription factor 21. (599 aa)
	ENSTGUP00000023546	annotation not available (228 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (420 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	ENSTGUP00000024522	annotation not available (197 aa)
	ENSTGUP00000024904	annotation not available (141 aa)
	LYN	Tyrosine-protein kinase. (605 aa)
	FBXW9	Uncharacterized protein. (526 aa)
	KLF10	Kruppel like factor 10. (455 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (317 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (797 aa)
	RASGRP1	RAS guanyl releasing protein 1. (792 aa)
	METTL3	Methyltransferase like 3. (449 aa)
	NLRP3	NACHT domain-containing protein. (901 aa)
	ENSTGUP00000027497	annotation not available (154 aa)
	PTPRC	Uncharacterized protein. (1194 aa)
	CBFB	Core-binding factor subunit beta. (408 aa)
	LOC115491434	USP8_interact domain-containing protein. (317 aa)
	ZC3H12A	C3H1-type domain-containing protein. (609 aa)
	ENSTGUP00000028794	annotation not available (369 aa)
	ENSTGUP00000028843	annotation not available (398 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (370 aa)
	CEBPB	CCAAT/enhancer-binding protein. (324 aa)
	TESC	Calcineurin B homologous protein 3 isoform X4. (337 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (938 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (259 aa)
	CCL19	C-C motif chemokine ligand 19. (152 aa)
	CASP8	Caspase 8. (480 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (840 aa)
	C1QC	Complement C1q subcomponent subunit C isoform X2. (310 aa)
	TCF7	Transcription factor 7. (462 aa)
	ANXA1	Annexin. (364 aa)
	IHH	Indian hedgehog signaling molecule. (408 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (653 aa)
	ENSTGUP00000037877	annotation not available (494 aa)
	LOC100228958	WD_REPEATS_REGION domain-containing protein. (783 aa)
	GAS6	Growth arrest specific 6. (704 aa)
	RHOH	Ras homolog family member H. (191 aa)
	ENSTGUP00000036756	annotation not available (99 aa)
	OCSTAMP	Osteoclast stimulatory transmembrane protein. (476 aa)
	XBP1	X-box binding protein 1. (260 aa)
	CYP26B1	Uncharacterized protein; Belongs to the cytochrome P450 family. (511 aa)
	LOC100218724	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	FBN1	Uncharacterized protein. (2931 aa)
	IL34	Uncharacterized protein. (226 aa)
	LEF1	Lymphoid enhancer binding factor 1. (412 aa)
	CEBPB-2	CCAAT enhancer binding protein beta. (324 aa)
	CARD11	Caspase recruitment domain family member 11. (1167 aa)
	MITF	Melanocyte inducing transcription factor. (535 aa)
	MALT1	MALT1 paracaspase. (878 aa)
	ENSTGUP00000033254	annotation not available (279 aa)
	PGLYRP2	N-acetylmuramoyl-L-alanine amidase. (493 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (690 aa)
	DUSP10	Dual specificity phosphatase 10. (481 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (199 aa)
	IGSF3	Immunoglobulin superfamily member 3. (1183 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (117 aa)
	ENSTGUP00000034023	annotation not available (490 aa)
	LRRC17	Uncharacterized protein. (438 aa)
	CD83	CD83 antigen. (246 aa)
	IKZF3	IKAROS family zinc finger 3. (561 aa)
	FADD	Fas associated via death domain. (221 aa)
	SMAD7	MH1 domain-containing protein. (392 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (644 aa)
	LOC100223311	Uncharacterized protein. (742 aa)
	PPARGC1B	PPARG coactivator 1 beta. (988 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	SYK	Tyrosine-protein kinase. (668 aa)
	PRELID1	PRELI domain containing 1. (215 aa)
	CRTAM	Cytotoxic and regulatory T cell molecule. (410 aa)
	IL19	Interleukin 19. (177 aa)
	IL10	Interleukin 10. (165 aa)
	SLC46A2	Solute carrier family 46 member 2. (452 aa)
	DROSHA	Drosha ribonuclease III. (1336 aa)
	IL7R	Interleukin 7 receptor. (460 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1322 aa)
	GATA3	GATA binding protein 3. (443 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (1322 aa)
	HLX	H2.0 like homeobox. (425 aa)
	FGL2	Fibrinogen like 2. (481 aa)
	SOX13	SRY-box transcription factor 13. (555 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
	HAX1	Uncharacterized protein. (275 aa)
	RC3H1	Uncharacterized protein. (1124 aa)
	VSIR	Ig-like domain-containing protein. (310 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	SASH3	Uncharacterized protein. (568 aa)
	TMEM131L	Transmembrane 131 like. (1615 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (817 aa)
	FOXN1	Fork-head domain-containing protein. (590 aa)
	SH3RF1	SH3 domain containing ring finger 1. (873 aa)
	FANCD2	FA complementation group D2. (1445 aa)
	LOC115496886	Protein kinase domain-containing protein. (554 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	FANCA	FA complementation group A. (1427 aa)
	PCID2	PCI domain containing 2. (400 aa)
	BCL6	BCL6 transcription repressor. (729 aa)
	NFAM1	Uncharacterized protein. (269 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (229 aa)
	LOC100223333	Caspase 8. (459 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (475 aa)
	GPR137B	G protein-coupled receptor 137B. (385 aa)
	LIF	LIF interleukin 6 family cytokine. (211 aa)
	MDK	Midkine. (139 aa)
	FBXO7	F-box protein 7. (527 aa)
	TOX	Thymocyte selection associated high mobility group box. (539 aa)
	MYB	MYB proto-oncogene, transcription factor. (764 aa)
	IL7	Uncharacterized protein. (179 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (553 aa)
	TMEM64	Transmembrane protein 64. (713 aa)
	PPP2R3C	EF-hand_13 domain-containing protein. (450 aa)
	TNFAIP6	TNF alpha induced protein 6. (296 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (472 aa)
	PRDM1	PR/SET domain 1. (789 aa)
	RB1	RB transcriptional corepressor 1. (931 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (501 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (711 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
	IL17A	Uncharacterized protein. (150 aa)
	CD4	Ig-like domain-containing protein. (396 aa)
	LAG3	Ig-like domain-containing protein. (344 aa)
	H1A1H3_TAEGU	Pentaxin. (227 aa)
	NFKBID	NF-kappa-B inhibitor delta. (391 aa)
	ENSTGUP00000019236	annotation not available (293 aa)
	ENSTGUP00000019351	annotation not available (381 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1299 aa)
	FSTL3	Follistatin-related protein 3. (246 aa)
	CD74	Uncharacterized protein. (289 aa)
	FBXW7	F-box and WD repeat domain containing 7. (745 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (245 aa)
	CREB1	cAMP responsive element binding protein 1. (324 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1214 aa)
	ZFPM1	Uncharacterized protein. (1560 aa)
	SOCS5	Suppressor of cytokine signaling 5. (535 aa)
	LOC105760451	CASPASE_P20 domain-containing protein. (760 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	CEBPB	ENSTGUP00000020549	ENSTGUP00000029463	Adiponectin, C1Q and collagen domain containing.	CCAAT/enhancer-binding protein.	0.473
ADIPOQ	CEBPB-2	ENSTGUP00000020549	ENSTGUP00000032270	Adiponectin, C1Q and collagen domain containing.	CCAAT enhancer binding protein beta.	0.473
ADIPOQ	IL10	ENSTGUP00000020549	ENSTGUP00000001118	Adiponectin, C1Q and collagen domain containing.	Interleukin 10.	0.485
AMBRA1	TRAF6	ENSTGUP00000019891	ENSTGUP00000024238	Autophagy and beclin 1 regulator 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.970
ANXA1	CSF1	ENSTGUP00000038342	ENSTGUP00000022274	Annexin.	Macrophage colony-stimulating factor 1 precursor.	0.522
BCL6	CD4	ENSTGUP00000009713	ENSTGUP00000013698	BCL6 transcription repressor.	Ig-like domain-containing protein.	0.499
BCL6	TBX21	ENSTGUP00000009713	ENSTGUP00000023254	BCL6 transcription repressor.	T-box transcription factor 21.	0.463
C1QC	CD74	ENSTGUP00000031620	ENSTGUP00000020182	Complement C1q subcomponent subunit C isoform X2.	Uncharacterized protein.	0.469
CARD11	CTLA4	ENSTGUP00000032603	ENSTGUP00000010068	Caspase recruitment domain family member 11.	Cytotoxic T-lymphocyte associated protein 4.	0.502
CARD11	FADD	ENSTGUP00000032603	ENSTGUP00000034889	Caspase recruitment domain family member 11.	Fas associated via death domain.	0.407
CARD11	LOC100223311	ENSTGUP00000032603	ENSTGUP00000000140	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.885
CARD11	LOC105760451	ENSTGUP00000032603	ENSTGUP00000022673	Caspase recruitment domain family member 11.	CASPASE_P20 domain-containing protein.	0.833
CARD11	LOC115496886	ENSTGUP00000032603	ENSTGUP00000007063	Caspase recruitment domain family member 11.	Protein kinase domain-containing protein.	0.471
CARD11	MALT1	ENSTGUP00000032603	ENSTGUP00000033187	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.885
CARD11	RIPK2	ENSTGUP00000032603	ENSTGUP00000012150	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.471
CARD11	SYK	ENSTGUP00000032603	ENSTGUP00000000435	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.556
CARD11	TRAF6	ENSTGUP00000032603	ENSTGUP00000024238	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.807
CARD11	ZAP70	ENSTGUP00000032603	ENSTGUP00000000339	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.655
CASP10	CASP8	ENSTGUP00000010628	ENSTGUP00000030393	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8.	0.835
CASP10	ENSTGUP00000024904	ENSTGUP00000010628	ENSTGUP00000024904	Caspase 10; Belongs to the peptidase C14A family.	annotation not available	0.414