(13 nodes) Guanyl-nucleotide exchange factor complex network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ELMO2	Engulfment and cell motility 2. (732 aa)
	EIF2B3	Eukaryotic translation initiation factor 2B subunit gamma. (452 aa)
	ELMO1	Engulfment and cell motility 1. (727 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (904 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (244 aa)
	LAMTOR4	Ragulator complex protein LAMTOR4 isoform X1. (99 aa)
	LOC115492746	Ragulator complex protein LAMTOR4-like. (117 aa)
	KNDC1	Uncharacterized protein. (1910 aa)
	RIC1	RIC1 homolog, RAB6A GEF complex partner 1. (1419 aa)
	WDR41	WD repeat domain 41. (488 aa)
	LAMTOR3	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (124 aa)
	RGP1	RGP1 homolog, RAB6A GEF complex partner 1. (419 aa)
	LAMTOR2	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (125 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELMO1	ELMO2	ENSTGUP00000032324	ENSTGUP00000028906	Engulfment and cell motility 1.	Engulfment and cell motility 2.	0.901
ELMO2	ELMO1	ENSTGUP00000028906	ENSTGUP00000032324	Engulfment and cell motility 2.	Engulfment and cell motility 1.	0.901
LAMTOR1	LAMTOR2	ENSTGUP00000031802	ENSTGUP00000003776	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.999
LAMTOR1	LAMTOR3	ENSTGUP00000031802	ENSTGUP00000030181	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.999
LAMTOR1	LAMTOR4	ENSTGUP00000031802	ENSTGUP00000032512	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ragulator complex protein LAMTOR4 isoform X1.	0.997
LAMTOR1	LOC115492746	ENSTGUP00000031802	ENSTGUP00000033586	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ragulator complex protein LAMTOR4-like.	0.978
LAMTOR2	LAMTOR1	ENSTGUP00000003776	ENSTGUP00000031802	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.999
LAMTOR2	LAMTOR3	ENSTGUP00000003776	ENSTGUP00000030181	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.999
LAMTOR2	LAMTOR4	ENSTGUP00000003776	ENSTGUP00000032512	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Ragulator complex protein LAMTOR4 isoform X1.	0.996
LAMTOR2	LOC115492746	ENSTGUP00000003776	ENSTGUP00000033586	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Ragulator complex protein LAMTOR4-like.	0.969
LAMTOR3	LAMTOR1	ENSTGUP00000030181	ENSTGUP00000031802	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.999
LAMTOR3	LAMTOR2	ENSTGUP00000030181	ENSTGUP00000003776	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.999
LAMTOR3	LAMTOR4	ENSTGUP00000030181	ENSTGUP00000032512	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Ragulator complex protein LAMTOR4 isoform X1.	0.976
LAMTOR3	LOC115492746	ENSTGUP00000030181	ENSTGUP00000033586	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	Ragulator complex protein LAMTOR4-like.	0.778
LAMTOR4	LAMTOR1	ENSTGUP00000032512	ENSTGUP00000031802	Ragulator complex protein LAMTOR4 isoform X1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.997
LAMTOR4	LAMTOR2	ENSTGUP00000032512	ENSTGUP00000003776	Ragulator complex protein LAMTOR4 isoform X1.	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.996
LAMTOR4	LAMTOR3	ENSTGUP00000032512	ENSTGUP00000030181	Ragulator complex protein LAMTOR4 isoform X1.	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.976
LOC115492746	LAMTOR1	ENSTGUP00000033586	ENSTGUP00000031802	Ragulator complex protein LAMTOR4-like.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.978
LOC115492746	LAMTOR2	ENSTGUP00000033586	ENSTGUP00000003776	Ragulator complex protein LAMTOR4-like.	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.969
LOC115492746	LAMTOR3	ENSTGUP00000033586	ENSTGUP00000030181	Ragulator complex protein LAMTOR4-like.	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.778