(108 nodes) C2 domain network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITSN1	Intersectin 1. (1710 aa)
	RASA1	RAS p21 protein activator 1. (996 aa)
	SYT2	Synaptotagmin 2. (415 aa)
	WWC1	WW and C2 domain containing 1. (1119 aa)
	UNC13B	Unc-13 homolog B. (1625 aa)
	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1614 aa)
	SYTL4	Synaptotagmin like 4. (717 aa)
	PLCH2	Phosphoinositide phospholipase C. (1583 aa)
	PLCL2	Phosphoinositide phospholipase C. (1130 aa)
	ITCH	E3 ubiquitin-protein ligase. (874 aa)
	PKN1	Uncharacterized protein. (949 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1223 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1282 aa)
	SYT9	Uncharacterized protein. (519 aa)
	CPNE2	Copine 2. (544 aa)
	C2CD2	C2 calcium dependent domain containing 2. (916 aa)
	PLCD4	Phosphoinositide phospholipase C. (753 aa)
	LOC100226015	Uncharacterized protein. (536 aa)
	CAPN6	Uncharacterized protein; Belongs to the peptidase C2 family. (644 aa)
	SYT7	Synaptotagmin 7. (684 aa)
	WWC2	WW and C2 domain containing 2. (1194 aa)
	UNC13C	Unc-13 homolog C. (2206 aa)
	PLCB2	Phosphoinositide phospholipase C. (1306 aa)
	SYT1	Synaptotagmin I. (425 aa)
	SMURF1	E3 ubiquitin-protein ligase. (737 aa)
	WWP2	E3 ubiquitin-protein ligase. (877 aa)
	UNC13D	Unc-13 homolog D. (1057 aa)
	RASA2	Uncharacterized protein. (845 aa)
	CPNE9	Copine family member 9. (545 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1700 aa)
	SYT8	Synaptotagmin 8. (393 aa)
	SYT17	Synaptotagmin 17. (474 aa)
	CC2D2A	C2 domain-containing protein. (1543 aa)
	BCR	Uncharacterized protein. (1349 aa)
	INPP4A	Inositol polyphosphate-4-phosphatase type I A. (954 aa)
	HECW2	Uncharacterized protein. (1562 aa)
	H0ZL27_TAEGU	Phospholipase A2. (865 aa)
	LOC100224874	Phospholipase A2. (821 aa)
	H0ZL87_TAEGU	Phospholipase A2. (749 aa)
	PLA2G4F	Phospholipase A2. (858 aa)
	SYTL3	Synaptotagmin like 3. (617 aa)
	PLCH1	Phosphoinositide phospholipase C. (1725 aa)
	ESYT3	Extended synaptotagmin 3. (841 aa)
	SYT10	Synaptotagmin 10. (522 aa)
	WWP1	E3 ubiquitin-protein ligase. (925 aa)
	PLCZ1	Phosphoinositide phospholipase C. (662 aa)
	SYT16	Synaptotagmin 16. (586 aa)
	PRKCH	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (686 aa)
	C2CD3	C2 domain containing 3 centriole elongation regulator. (2194 aa)
	UVRAG	UV radiation resistance associated. (687 aa)
	H0ZL64_TAEGU	PLA2c domain-containing protein. (710 aa)
	PLCD3	Phosphoinositide phospholipase C. (830 aa)
	H0ZYF8_TAEGU	PLA2c domain-containing protein. (739 aa)
	DYSF	Uncharacterized protein. (2049 aa)
	SYT11	Synaptotagmin 11. (484 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1609 aa)
	PLCL1	Phosphoinositide phospholipase C. (1101 aa)
	RASA3	RAS p21 protein activator 3. (895 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (5193 aa)
	LOC100222362	Phosphoinositide phospholipase C. (1311 aa)
	SYDE2	Synapse defective Rho GTPase homolog 2. (987 aa)
	SYT14	Synaptotagmin 14. (816 aa)
	SMURF2	E3 ubiquitin-protein ligase. (777 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
	TOLLIP	Toll interacting protein. (280 aa)
	H0ZL67_TAEGU	Phospholipase A2. (798 aa)
	MYOF	Uncharacterized protein. (2058 aa)
	MCTP1	Multiple C2 and transmembrane domain containing 1. (926 aa)
	C2CD5	C2 calcium dependent domain containing 5. (1176 aa)
	ESYT2	Uncharacterized protein. (913 aa)
	CADPS2	Uncharacterized protein. (1301 aa)
	H0YPK2_TAEGU	Uncharacterized protein. (1716 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1606 aa)
	LOC100224303	C2 domain-containing protein. (487 aa)
	LOC100228479	Phosphoinositide phospholipase C. (1025 aa)
	CADPS	Uncharacterized protein. (1355 aa)
	SYT12	Synaptotagmin 12. (472 aa)
	ITSN2	Intersectin 2. (1782 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (763 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1212 aa)
	ABR	ABR activator of RhoGEF and GTPase. (861 aa)
	CPNE8	Copine 8. (639 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1502 aa)
	LOC100230025	Ras-GAP domain-containing protein. (860 aa)
	CAPN5	Calpain 5; Belongs to the peptidase C2 family. (700 aa)
	RAB11FIP2	RAB11 family interacting protein 2. (502 aa)
	RIMS2	Uncharacterized protein. (1488 aa)
	PLCD1	Phosphoinositide phospholipase C. (749 aa)
	CPNE4	Copine 4. (578 aa)
	MCTP2	Uncharacterized protein. (887 aa)
	RASAL1	RAS protein activator like 1. (956 aa)
	RASAL2	Uncharacterized protein. (1957 aa)
	RPH3A	Rabphilin 3A. (675 aa)
	SYT4	Uncharacterized protein. (571 aa)
	PRKCE	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
	CEP120	Centrosomal protein 120. (1009 aa)
	SYTL5	Synaptotagmin like 5. (757 aa)
	DAB2IP	DAB2 interacting protein. (1193 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (1284 aa)
	TC2N	C2 domain-containing protein. (500 aa)
	PRKCB	Protein kinase C beta; Belongs to the protein kinase superfamily. (673 aa)
	SYT6	Synaptotagmin 6. (520 aa)
	PLA2G4A	Phospholipase A2. (748 aa)
	NEDD4	E3 ubiquitin-protein ligase. (1302 aa)
	PLCE1	Phosphoinositide phospholipase C. (2331 aa)
	WWC3	WWC family member 3. (1186 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	SYDE2	ENSTGUP00000030746	ENSTGUP00000021147	ABR activator of RhoGEF and GTPase.	Synapse defective Rho GTPase homolog 2.	0.419
BCR	SYDE2	ENSTGUP00000010330	ENSTGUP00000021147	Uncharacterized protein.	Synapse defective Rho GTPase homolog 2.	0.419
CADPS	RIMS2	ENSTGUP00000029191	ENSTGUP00000033110	Uncharacterized protein.	Uncharacterized protein.	0.555
CADPS2	RIMS2	ENSTGUP00000024447	ENSTGUP00000033110	Uncharacterized protein.	Uncharacterized protein.	0.555
CAPN5	ITSN2	ENSTGUP00000031995	ENSTGUP00000029821	Calpain 5; Belongs to the peptidase C2 family.	Intersectin 2.	0.603
CAPN6	ITSN2	ENSTGUP00000006412	ENSTGUP00000029821	Uncharacterized protein; Belongs to the peptidase C2 family.	Intersectin 2.	0.603
DAB2IP	RASA1	ENSTGUP00000036524	ENSTGUP00000001217	DAB2 interacting protein.	RAS p21 protein activator 1.	0.479
ESYT2	ITSN1	ENSTGUP00000024312	ENSTGUP00000000534	Uncharacterized protein.	Intersectin 1.	0.618
ESYT2	ITSN2	ENSTGUP00000024312	ENSTGUP00000029821	Uncharacterized protein.	Intersectin 2.	0.618
ESYT3	ITSN1	ENSTGUP00000011871	ENSTGUP00000000534	Extended synaptotagmin 3.	Intersectin 1.	0.618
ESYT3	ITSN2	ENSTGUP00000011871	ENSTGUP00000029821	Extended synaptotagmin 3.	Intersectin 2.	0.618
H0YPK2_TAEGU	RIMS1	ENSTGUP00000025839	ENSTGUP00000026348	Uncharacterized protein.	Regulating synaptic membrane exocytosis 1.	0.712
H0YPK2_TAEGU	RIMS2	ENSTGUP00000025839	ENSTGUP00000033110	Uncharacterized protein.	Uncharacterized protein.	0.999
H0YPK2_TAEGU	SYT1	ENSTGUP00000025839	ENSTGUP00000007815	Uncharacterized protein.	Synaptotagmin I.	0.605
H0YPK2_TAEGU	SYT2	ENSTGUP00000025839	ENSTGUP00000001345	Uncharacterized protein.	Synaptotagmin 2.	0.605
H0ZL27_TAEGU	PLCG1	ENSTGUP00000011300	ENSTGUP00000004946	Phospholipase A2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.900
H0ZL27_TAEGU	PLCG2	ENSTGUP00000011300	ENSTGUP00000004589	Phospholipase A2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.901
HECW1	ITSN2	ENSTGUP00000001878	ENSTGUP00000029821	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	Intersectin 2.	0.586
HECW2	ITSN2	ENSTGUP00000011003	ENSTGUP00000029821	Uncharacterized protein.	Intersectin 2.	0.586
INPP4A	PIK3C2A	ENSTGUP00000010555	ENSTGUP00000008892	Inositol polyphosphate-4-phosphatase type I A.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.926