STRINGSTRING
SPNS3 SPNS3 PLCG2 PLCG2 B2M B2M VAV3 VAV3 GRB2 GRB2 SYK SYK SHC1 SHC1 HRAS HRAS KRAS KRAS GRAP2 GRAP2 ENSTGUP00000034337 ENSTGUP00000034337 LOC100231469-2 LOC100231469-2 ENSTGUP00000030877 ENSTGUP00000030877 VAV2 VAV2 LOC105761003 LOC105761003 KLRG1 KLRG1 LOC100231469 LOC100231469 PIK3CB PIK3CB LOC100222362 LOC100222362 PIK3R2 PIK3R2 ENSTGUP00000020196 ENSTGUP00000020196 PIK3CA PIK3CA CSDE1 CSDE1 NRAS NRAS TREM2 TREM2 SOS1 SOS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPNS3Sphingolipid transporter 3 (putative). (498 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1223 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (170 aa)
VAV3Vav guanine nucleotide exchange factor 3. (846 aa)
GRB2Putative growth factor receptor-bound protein 2. (217 aa)
SYKTyrosine-protein kinase. (668 aa)
SHC1SHC adaptor protein 1. (609 aa)
HRASPutative v-Ha-ras Harvey sarcoma viral oncogene variant 2. (189 aa)
KRASGTPase KRas. (217 aa)
GRAP2Uncharacterized protein. (296 aa)
ENSTGUP00000034337annotation not available (812 aa)
LOC100231469-2Ig-like domain-containing protein; Belongs to the MHC class I family. (561 aa)
ENSTGUP00000030877annotation not available (147 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
LOC105761003Ig domain-containing protein. (305 aa)
KLRG1Killer cell lectin-like receptor subfamily G member 1. (191 aa)
LOC100231469Class I histocompatibility antigen, F10 alpha chain-like. (544 aa)
PIK3CBUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC100222362Phosphoinositide phospholipase C. (1311 aa)
PIK3R2Uncharacterized protein. (727 aa)
ENSTGUP000000201961-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1. (1281 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CSDE1Cold shock domain containing E1. (796 aa)
NRASNRAS proto-oncogene, GTPase. (280 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (262 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1322 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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