(40 nodes) Recycling pathway of L1 network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DNM3	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (833 aa)
	LOC115492856	Adaptor related protein complex 2 subunit sigma 1. (147 aa)
	LOC115492856-2	AP-2 complex subunit sigma. (185 aa)
	TUBA8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
	DNM2-2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (829 aa)
	LOC115497576	Tubulin beta-4B chain. (495 aa)
	LOC100223131	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
	TUBB2A	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
	LOC100218848	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (615 aa)
	TUBAL3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (480 aa)
	NUMB	NUMB endocytic adaptor protein. (671 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1181 aa)
	ENSTGUP00000028988	annotation not available (856 aa)
	DNM2	Dynamin 2. (400 aa)
	LOC100229883	Actin, cytoplasmic type 5. (459 aa)
	SHTN1	Shootin 1. (682 aa)
	LOC100229883-2	Uncharacterized protein. (459 aa)
	MSN	Moesin. (580 aa)
	TUBB4B	Tubulin beta 4B class IVb. (445 aa)
	HMCN1	Hemicentin 1. (1361 aa)
	DPYSL2	Dihydropyrimidinase like 2. (739 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
	SRC	Tyrosine-protein kinase. (553 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (966 aa)
	AP2M1	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (437 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1139 aa)
	EZR	Ezrin. (586 aa)
	TUBA1B	Tubulin alpha-1A chain. (457 aa)
	HMCN1-2	Hemicentin-1. (116 aa)
	RDX	Radixin. (594 aa)
	ACTG1	Actin, cytoplasmic 2. (681 aa)
	DNM1	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (852 aa)
	ACTB	Uncharacterized protein. (462 aa)
	LOC100229371	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (246 aa)
	LOC100223640	Uncharacterized protein. (1193 aa)
	ENSTGUP00000025387	annotation not available (1018 aa)
	TUBB6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	LOC115490530	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSTGUP00000023808	ENSTGUP00000030258	Uncharacterized protein.	Actin, cytoplasmic 2.	0.901
ACTB	EZR	ENSTGUP00000023808	ENSTGUP00000011392	Uncharacterized protein.	Ezrin.	0.924
ACTB	LOC100218848	ENSTGUP00000023808	ENSTGUP00000026959	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.489
ACTB	LOC100223131	ENSTGUP00000023808	ENSTGUP00000021688	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.490
ACTB	LOC100229371	ENSTGUP00000023808	ENSTGUP00000025301	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.489
ACTB	LOC100229883-2	ENSTGUP00000023808	ENSTGUP00000037065	Uncharacterized protein.	Uncharacterized protein.	0.901
ACTB	LOC115490530	ENSTGUP00000023808	ENSTGUP00000016238	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.487
ACTB	MSN	ENSTGUP00000023808	ENSTGUP00000002920	Uncharacterized protein.	Moesin.	0.923
ACTB	RDX	ENSTGUP00000023808	ENSTGUP00000031699	Uncharacterized protein.	Radixin.	0.922
ACTB	TUBA1B	ENSTGUP00000023808	ENSTGUP00000032907	Uncharacterized protein.	Tubulin alpha-1A chain.	0.486
ACTB	TUBA8	ENSTGUP00000023808	ENSTGUP00000020332	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.496
ACTB	TUBAL3	ENSTGUP00000023808	ENSTGUP00000027973	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.500
ACTG1	ACTB	ENSTGUP00000030258	ENSTGUP00000023808	Actin, cytoplasmic 2.	Uncharacterized protein.	0.901
ACTG1	EZR	ENSTGUP00000030258	ENSTGUP00000011392	Actin, cytoplasmic 2.	Ezrin.	0.924
ACTG1	LOC100218848	ENSTGUP00000030258	ENSTGUP00000026959	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.487
ACTG1	LOC100223131	ENSTGUP00000030258	ENSTGUP00000021688	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.488
ACTG1	LOC100229371	ENSTGUP00000030258	ENSTGUP00000025301	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.487
ACTG1	LOC100229883-2	ENSTGUP00000030258	ENSTGUP00000037065	Actin, cytoplasmic 2.	Uncharacterized protein.	0.901
ACTG1	LOC115490530	ENSTGUP00000030258	ENSTGUP00000016238	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.485
ACTG1	MSN	ENSTGUP00000030258	ENSTGUP00000002920	Actin, cytoplasmic 2.	Moesin.	0.923