(24 nodes) Translesion synthesis by POLK network (Taeniopygia guttata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA2	Replication protein A2. (274 aa)
	KXD1	KxDL motif containing 1. (176 aa)
	MAD2L2	HORMA domain-containing protein. (203 aa)
	RFC2	Replication factor C subunit 2. (356 aa)
	ATAD5	ATPase family AAA domain containing 5. (1827 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (613 aa)
	POLK	DNA polymerase kappa. (866 aa)
	MEIOB	Uncharacterized protein. (472 aa)
	UBB	Ubiquitin B. (411 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1256 aa)
	RFC4	AAA domain-containing protein. (362 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3164 aa)
	RPA3	Uncharacterized protein. (244 aa)
	PCNA	Proliferating cell nuclear antigen. (269 aa)
	LOC115498157	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	RFC5	Replication factor C subunit 5. (527 aa)
	ENSTGUP00000032408	annotation not available (388 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (619 aa)
	ENSTGUP00000035639	annotation not available (89 aa)
	RFC1	Replication factor C subunit 1. (1325 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (566 aa)
	ENSTGUP00000037953	annotation not available (153 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ENSTGUP00000032408	ENSTGUP00000005092	ENSTGUP00000032408	ATPase family AAA domain containing 5.	annotation not available	0.710
ATAD5	LOC115498157	ENSTGUP00000005092	ENSTGUP00000029503	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.919
ATAD5	MAD2L2	ENSTGUP00000005092	ENSTGUP00000002407	ATPase family AAA domain containing 5.	HORMA domain-containing protein.	0.658
ATAD5	MEIOB	ENSTGUP00000005092	ENSTGUP00000006941	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.710
ATAD5	PCNA	ENSTGUP00000005092	ENSTGUP00000028759	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen.	0.919
ATAD5	POLK	ENSTGUP00000005092	ENSTGUP00000006376	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.662
ATAD5	REV1	ENSTGUP00000005092	ENSTGUP00000010413	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.670
ATAD5	REV3L	ENSTGUP00000005092	ENSTGUP00000012386	ATPase family AAA domain containing 5.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.771
ATAD5	RFC1	ENSTGUP00000005092	ENSTGUP00000036781	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.681
ATAD5	RFC2	ENSTGUP00000005092	ENSTGUP00000004002	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.979
ATAD5	RFC3	ENSTGUP00000005092	ENSTGUP00000012175	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.988
ATAD5	RFC4	ENSTGUP00000005092	ENSTGUP00000010809	ATPase family AAA domain containing 5.	AAA domain-containing protein.	0.992
ATAD5	RFC5	ENSTGUP00000005092	ENSTGUP00000031001	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.985
ATAD5	RPA1	ENSTGUP00000005092	ENSTGUP00000005967	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.710
ATAD5	RPA2	ENSTGUP00000005092	ENSTGUP00000000889	ATPase family AAA domain containing 5.	Replication protein A2.	0.576
ATAD5	RPA3	ENSTGUP00000005092	ENSTGUP00000027230	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.595
ATAD5	RPS27A	ENSTGUP00000005092	ENSTGUP00000007289	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.610
ENSTGUP00000032408	ATAD5	ENSTGUP00000032408	ENSTGUP00000005092	annotation not available	ATPase family AAA domain containing 5.	0.710
ENSTGUP00000032408	LOC115498157	ENSTGUP00000032408	ENSTGUP00000029503	annotation not available	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.795
ENSTGUP00000032408	MAD2L2	ENSTGUP00000032408	ENSTGUP00000002407	annotation not available	HORMA domain-containing protein.	0.482