(18 nodes) Ubiquitin Mediated Degradation of Phosphorylated Cdc25A network (Taeniopygia guttata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSTGUP00000035639	annotation not available (89 aa)
	ENSTGUP00000037953	annotation not available (153 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4. (839 aa)
	ENSTGUP00000035718	annotation not available (293 aa)
	ENSTGUP00000034482	annotation not available (830 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (351 aa)
	ENSTGUP00000026893	annotation not available (392 aa)
	LOC115493039	Proteasome subunit beta type-5-like. (353 aa)
	PSMD10	26S proteasome non-ATPase regulatory subunit 10. (226 aa)
	PSMA7	Proteasome subunit alpha type. (255 aa)
	PSMC1	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (956 aa)
	LOC100190416	Proteasome subunit alpha type. (261 aa)
	CHEK2	Checkpoint kinase 2. (532 aa)
	PSME4	Proteasome activator subunit 4. (1822 aa)
	UBB	Ubiquitin B. (411 aa)
	KXD1	KxDL motif containing 1. (176 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHEK1	CHEK2	ENSTGUP00000000812	ENSTGUP00000008109	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Checkpoint kinase 2.	0.992
CHEK2	CHEK1	ENSTGUP00000008109	ENSTGUP00000000812	Checkpoint kinase 2.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.992
CHEK2	ENSTGUP00000035639	ENSTGUP00000008109	ENSTGUP00000035639	Checkpoint kinase 2.	annotation not available	0.432
ENSTGUP00000026893	ENSTGUP00000034482	ENSTGUP00000026893	ENSTGUP00000034482	annotation not available	annotation not available	0.928
ENSTGUP00000026893	ENSTGUP00000035639	ENSTGUP00000026893	ENSTGUP00000035639	annotation not available	annotation not available	0.752
ENSTGUP00000026893	ENSTGUP00000035718	ENSTGUP00000026893	ENSTGUP00000035718	annotation not available	annotation not available	0.899
ENSTGUP00000026893	ENSTGUP00000037953	ENSTGUP00000026893	ENSTGUP00000037953	annotation not available	annotation not available	0.752
ENSTGUP00000026893	LOC100190416	ENSTGUP00000026893	ENSTGUP00000008725	annotation not available	Proteasome subunit alpha type.	0.953
ENSTGUP00000026893	LOC115493039	ENSTGUP00000026893	ENSTGUP00000026645	annotation not available	Proteasome subunit beta type-5-like.	0.899
ENSTGUP00000026893	PSMA7	ENSTGUP00000026893	ENSTGUP00000022969	annotation not available	Proteasome subunit alpha type.	0.976
ENSTGUP00000026893	PSMC1	ENSTGUP00000026893	ENSTGUP00000012822	annotation not available	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.970
ENSTGUP00000026893	PSMC4	ENSTGUP00000026893	ENSTGUP00000037733	annotation not available	Proteasome 26S subunit, ATPase 4.	0.928
ENSTGUP00000026893	PSMD1	ENSTGUP00000026893	ENSTGUP00000010055	annotation not available	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	0.956
ENSTGUP00000026893	PSMD10	ENSTGUP00000026893	ENSTGUP00000024445	annotation not available	26S proteasome non-ATPase regulatory subunit 10.	0.889
ENSTGUP00000026893	PSME4	ENSTGUP00000026893	ENSTGUP00000007466	annotation not available	Proteasome activator subunit 4.	0.584
ENSTGUP00000026893	UBB	ENSTGUP00000026893	ENSTGUP00000007038	annotation not available	Ubiquitin B.	0.752
ENSTGUP00000034482	ENSTGUP00000026893	ENSTGUP00000034482	ENSTGUP00000026893	annotation not available	annotation not available	0.928
ENSTGUP00000034482	ENSTGUP00000035639	ENSTGUP00000034482	ENSTGUP00000035639	annotation not available	annotation not available	0.769
ENSTGUP00000034482	ENSTGUP00000035718	ENSTGUP00000034482	ENSTGUP00000035718	annotation not available	annotation not available	0.911
ENSTGUP00000034482	ENSTGUP00000037953	ENSTGUP00000034482	ENSTGUP00000037953	annotation not available	annotation not available	0.769