(72 nodes) Signaling by Insulin receptor network (Taeniopygia guttata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	INSR	Insulin receptor. (1323 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (150 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1322 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (453 aa)
	GAB1	GRB2 associated binding protein 1. (720 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
	ATP6AP1	Uncharacterized protein. (458 aa)
	FGFR1	Fibroblast growth factor receptor. (820 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (849 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ATP6V0D1	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (582 aa)
	ATP6AP1L	ATPase H+ transporting accessory protein 1 like. (343 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (818 aa)
	ATP6V0B	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family. (194 aa)
	CNST	Consortin, connexin sorting protein. (719 aa)
	PDE3B	Phosphodiesterase. (1112 aa)
	GRB2	Putative growth factor receptor-bound protein 2. (217 aa)
	LOC100227679	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	NRDC	Uncharacterized protein; Belongs to the peptidase M16 family. (1155 aa)
	KLB	Klotho beta. (1006 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (137 aa)
	LOC100190507	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	FGFR3	Fibroblast growth factor receptor. (794 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (844 aa)
	ATP6V0D2	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	KL	Klotho. (199 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (253 aa)
	GAB2	GRB2 associated binding protein 2. (680 aa)
	ATP6V1A	Uncharacterized protein. (668 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type 1. (432 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ATP6V1B1	V-type proton ATPase subunit B, kidney isoform. (503 aa)
	FLT3	Protein kinase domain-containing protein. (1019 aa)
	ATP6V1G1	V-type H+-transporting ATPase subunit G. (133 aa)
	SHC1	SHC adaptor protein 1. (609 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGFR4	Fibroblast growth factor receptor. (865 aa)
	PIK3R2	Uncharacterized protein. (727 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1022 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (545 aa)
	PIK3CB	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ATP6V1E1	Putative ATPase H+ transporting lysosomal 31 kDa V1 subunit E. (226 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	FGFR2	Fibroblast growth factor receptor. (891 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (480 aa)
	ENSTGUP00000026806	annotation not available (421 aa)
	FGF4	Fibroblast growth factor 4. (194 aa)
	ATP6V1D	ATPase H+ transporting V1 subunit D. (246 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (555 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1877 aa)
	ATP6V1F	V-type H+-transporting ATPase subunit F. (227 aa)
	ATP6V1C2	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (392 aa)
	ENSTGUP00000031299	annotation not available (304 aa)
	ENSTGUP00000031619	annotation not available (271 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (861 aa)
	ENSTGUP00000034340	V-type proton ATPase catalytic subunit A. (613 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (396 aa)
	ATP6V1G3	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (162 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
	ENSTGUP00000036441	annotation not available (119 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (529 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	ATP6V0A1	ENSTGUP00000004468	ENSTGUP00000032498	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.983
ATP6AP1	ATP6V0A2	ENSTGUP00000004468	ENSTGUP00000005390	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.978
ATP6AP1	ATP6V0A4	ENSTGUP00000004468	ENSTGUP00000011774	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.983
ATP6AP1	ATP6V0B	ENSTGUP00000004468	ENSTGUP00000007770	Uncharacterized protein.	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family.	0.974
ATP6AP1	ATP6V0C	ENSTGUP00000004468	ENSTGUP00000003350	Uncharacterized protein.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.995
ATP6AP1	ATP6V0D1	ENSTGUP00000004468	ENSTGUP00000006060	Uncharacterized protein.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.991
ATP6AP1	ATP6V0D2	ENSTGUP00000004468	ENSTGUP00000012100	Uncharacterized protein.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.991
ATP6AP1	ATP6V1A	ENSTGUP00000004468	ENSTGUP00000013753	Uncharacterized protein.	Uncharacterized protein.	0.842
ATP6AP1	ATP6V1B1	ENSTGUP00000004468	ENSTGUP00000017579	Uncharacterized protein.	V-type proton ATPase subunit B, kidney isoform.	0.917
ATP6AP1	ATP6V1B2	ENSTGUP00000004468	ENSTGUP00000020909	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.917
ATP6AP1	ATP6V1C1	ENSTGUP00000004468	ENSTGUP00000012502	Uncharacterized protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.902
ATP6AP1	ATP6V1C2	ENSTGUP00000004468	ENSTGUP00000030785	Uncharacterized protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.892
ATP6AP1	ATP6V1D	ENSTGUP00000004468	ENSTGUP00000029282	Uncharacterized protein.	ATPase H+ transporting V1 subunit D.	0.950
ATP6AP1	ATP6V1E1	ENSTGUP00000004468	ENSTGUP00000022829	Uncharacterized protein.	Putative ATPase H+ transporting lysosomal 31 kDa V1 subunit E.	0.963
ATP6AP1	ATP6V1F	ENSTGUP00000004468	ENSTGUP00000030592	Uncharacterized protein.	V-type H+-transporting ATPase subunit F.	0.913
ATP6AP1	ATP6V1G1	ENSTGUP00000004468	ENSTGUP00000019191	Uncharacterized protein.	V-type H+-transporting ATPase subunit G.	0.889
ATP6AP1	ATP6V1G3	ENSTGUP00000004468	ENSTGUP00000034797	Uncharacterized protein.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.886
ATP6AP1	ATP6V1H	ENSTGUP00000004468	ENSTGUP00000026633	Uncharacterized protein.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.996
ATP6AP1	CNST	ENSTGUP00000004468	ENSTGUP00000008652	Uncharacterized protein.	Consortin, connexin sorting protein.	0.823
ATP6AP1	ENSTGUP00000031619	ENSTGUP00000004468	ENSTGUP00000031619	Uncharacterized protein.	annotation not available	0.842