STRINGSTRING
HIF1A HIF1A ESR1 ESR1 IGF2 IGF2 INS INS IRS1 IRS1 IGFBP1 IGFBP1 TLR4 TLR4 MTOR MTOR IGFBP2 IGFBP2 AQP4 AQP4 PDGFB PDGFB RPS6 RPS6 IGFBP3 IGFBP3 MMP9 MMP9 GSK3B GSK3B PLAU PLAU ALB ALB MBP MBP MIF MIF BDNF BDNF TSC2 TSC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (621 aa)
IGF2IlGF domain-containing protein. (225 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (137 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
IGFBP1Insulin like growth factor binding protein 1. (277 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (842 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (1322 aa)
IGFBP2Insulin like growth factor binding protein 2. (310 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (337 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (278 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (254 aa)
IGFBP3Insulin like growth factor binding protein 3. (286 aa)
MMP9Matrix metallopeptidase 9. (723 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PLAUUncharacterized protein. (457 aa)
ALBUncharacterized protein. (615 aa)
MBPMyelin basic protein. (326 aa)
MIFMacrophage migration inhibitory factor. (114 aa)
BDNFBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (254 aa)
TSC2TSC complex subunit 2. (1835 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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