STRINGSTRING
FGF8 FGF8 FGF1 FGF1 MAP2 MAP2 FGF9 FGF9 FGF5 FGF5 PDGFRA PDGFRA FGF12 FGF12 ROR2 ROR2 FGF10 FGF10 GDNF GDNF ASCL1 ASCL1 FGF4 FGF4 PAX6 PAX6 FGF19 FGF19 ITGA6 ITGA6 FGF2 FGF2 DLX2 DLX2 BDNF BDNF MAG MAG FGF7 FGF7 FGF18 FGF18 CD44 CD44 FGF6 FGF6 CXCR4 CXCR4 FGF14 FGF14 ROR1-2 ROR1-2 LOC100218935 LOC100218935 PROM1 PROM1 FGF20 FGF20 WNT5A WNT5A TBR1 TBR1 DCX DCX FGF16 FGF16 FGF3 FGF3 VCAM1 VCAM1 BECN1 BECN1 STAT3 STAT3 FGF13 FGF13 EGFR EGFR IRF1 IRF1 SHH SHH FGF22 FGF22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
MAP2Microtubule-associated protein. (1946 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1109 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (938 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
GDNFGlial cell derived neurotrophic factor. (218 aa)
ASCL1Achaete-scute complex protein. (218 aa)
FGF4Fibroblast growth factor 4. (194 aa)
PAX6Paired box 6. (447 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
ITGA6Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1102 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
DLX2Distal-less homeobox 2. (341 aa)
BDNFBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (254 aa)
MAGMyelin associated glycoprotein. (541 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CD44CD44 molecule (Indian blood group). (775 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (446 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
ROR1-2Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
LOC100218935Uncharacterized protein. (797 aa)
PROM1Prominin 1. (870 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
TBR1T-box brain transcription factor 1. (642 aa)
DCXDoublecortin. (365 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
VCAM1Vascular cell adhesion molecule 1. (542 aa)
BECN1Uncharacterized protein. (449 aa)
STAT3Signal transducer and activator of transcription. (811 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (453 aa)
EGFRReceptor protein-tyrosine kinase. (1222 aa)
IRF1Interferon regulatory factor. (315 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (425 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (150 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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