(43 nodes) c4 zinc finger in nuclear hormone receptors network (Taeniopygia guttata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RXRG	Uncharacterized protein. (484 aa)
	LOC115491390	Nuclear receptor subfamily 4 group A member 1. (574 aa)
	LOC115491412	Vitamin D3 receptor. (429 aa)
	LOC100221284	Vitamin D receptor. (429 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (397 aa)
	ESRRG	Estrogen related receptor gamma. (517 aa)
	PPARD	Uncharacterized protein. (449 aa)
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (1010 aa)
	HNF4A	Uncharacterized protein. (464 aa)
	THRA	Thyroid hormone receptor alpha. (408 aa)
	PGR	Progesterone receptor. (776 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (601 aa)
	NR2C1	Nuclear receptor subfamily 2 group C member 1. (640 aa)
	RORA	RAR related orphan receptor A. (468 aa)
	NR2E3	Uncharacterized protein. (404 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (499 aa)
	LOC100227703	Uncharacterized protein. (457 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (473 aa)
	RARB	Uncharacterized protein. (526 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (573 aa)
	AR	Androgen receptor. (684 aa)
	LOC100227863	Uncharacterized protein. (507 aa)
	RORB	RAR related orphan receptor B. (464 aa)
	LOC100221315	Nuclear receptor domain-containing protein. (465 aa)
	ENSTGUP00000029122	annotation not available (306 aa)
	ESR2	Uncharacterized protein. (568 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (574 aa)
	NR3C1	Uncharacterized protein. (813 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (553 aa)
	RXRA	Retinoid X receptor alpha. (503 aa)
	NR2F2	Nuclear receptor subfamily 2 group F member 2. (415 aa)
	LOC100231563	Nuclear receptor subfamily 4 group A member 1. (574 aa)
	THRB	Uncharacterized protein. (402 aa)
	NR6A1	Nuclear receptor subfamily 6 group A member 1 isoform X1. (472 aa)
	RARG	NR LBD domain-containing protein. (426 aa)
	RARA	NR LBD domain-containing protein. (507 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (473 aa)
	NR1H3	Uncharacterized protein. (418 aa)
	NR2C2	Nuclear receptor subfamily 2 group C member 2. (593 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (621 aa)
	HNF4G	Hepatocyte nuclear factor 4 gamma. (454 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	NR4A2	Nuclear receptor domain-containing protein. (598 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSTGUP00000002859	ENSTGUP00000011604	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.728
AR	ESR2	ENSTGUP00000002859	ENSTGUP00000029826	Androgen receptor.	Uncharacterized protein.	0.451
AR	NR3C1	ENSTGUP00000002859	ENSTGUP00000030597	Androgen receptor.	Uncharacterized protein.	0.641
AR	NR3C2	ENSTGUP00000002859	ENSTGUP00000025990	Androgen receptor.	Nuclear receptor subfamily 3 group C member 2.	0.624
AR	PGR	ENSTGUP00000002859	ENSTGUP00000031224	Androgen receptor.	Progesterone receptor.	0.647
ENSTGUP00000029122	LOC100221284	ENSTGUP00000029122	ENSTGUP00000020085	annotation not available	Vitamin D receptor.	0.683
ENSTGUP00000029122	LOC100227863	ENSTGUP00000029122	ENSTGUP00000000987	annotation not available	Uncharacterized protein.	0.810
ENSTGUP00000029122	LOC115491412	ENSTGUP00000029122	ENSTGUP00000017389	annotation not available	Vitamin D3 receptor.	0.683
ENSTGUP00000029122	NR1D2	ENSTGUP00000029122	ENSTGUP00000003445	annotation not available	Nuclear receptor subfamily 1 group D member 2.	0.475
ENSTGUP00000029122	NR1H3	ENSTGUP00000029122	ENSTGUP00000010811	annotation not available	Uncharacterized protein.	0.902
ENSTGUP00000029122	NR1H4	ENSTGUP00000029122	ENSTGUP00000009262	annotation not available	Nuclear receptor subfamily 1 group H member 4.	0.818
ENSTGUP00000029122	PPARA	ENSTGUP00000029122	ENSTGUP00000012160	annotation not available	Peroxisome proliferator activated receptor alpha.	0.801
ENSTGUP00000029122	PPARD	ENSTGUP00000029122	ENSTGUP00000022654	annotation not available	Uncharacterized protein.	0.727
ENSTGUP00000029122	PPARG	ENSTGUP00000029122	ENSTGUP00000004204	annotation not available	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.858
ENSTGUP00000029122	RARA	ENSTGUP00000029122	ENSTGUP00000038607	annotation not available	NR LBD domain-containing protein.	0.662
ENSTGUP00000029122	RARB	ENSTGUP00000029122	ENSTGUP00000003501	annotation not available	Uncharacterized protein.	0.662
ENSTGUP00000029122	RARG	ENSTGUP00000029122	ENSTGUP00000038138	annotation not available	NR LBD domain-containing protein.	0.662
ENSTGUP00000029122	THRA	ENSTGUP00000029122	ENSTGUP00000027126	annotation not available	Thyroid hormone receptor alpha.	0.641
ENSTGUP00000029122	THRB	ENSTGUP00000029122	ENSTGUP00000036792	annotation not available	Uncharacterized protein.	0.641
ESR1	AR	ENSTGUP00000011604	ENSTGUP00000002859	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Androgen receptor.	0.728