61 items (Taeniopygia guttata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	EI24	EI24 autophagy associated transmembrane protein. (343 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (435 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (338 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (263 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (377 aa)
	GTSE1	Uncharacterized protein. (659 aa)
	AIFM2	Ferroptosis suppressor protein 1; A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical- trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end produ [...] (373 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (401 aa)
	BCL2L1	BCL2 like 1. (230 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (282 aa)
	CHEK2	Checkpoint kinase 2. (532 aa)
	ATR	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2658 aa)
	SIAH1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (384 aa)
	LOC100231625	TNFR-Cys domain-containing protein. (308 aa)
	PIDD1	P53-induced death domain protein 1. (894 aa)
	CD82	Tetraspanin. (265 aa)
	LOC100223333	Caspase 8. (459 aa)
	DDB2	Damage specific DNA binding protein 2. (464 aa)
	STEAP3	Uncharacterized protein. (488 aa)
	THBS1	Uncharacterized protein. (1173 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (405 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (347 aa)
	SESN1	Sestrin 1. (538 aa)
	ATM	Non-specific serine/threonine protein kinase. (2226 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (397 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (356 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (420 aa)
	GORAB	Uncharacterized protein. (380 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (247 aa)
	LOC115496180	Growth arrest and DNA damage-inducible protein GADD45 alpha. (157 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (286 aa)
	ADGRB1	Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1629 aa)
	SESN3	Uncharacterized protein. (488 aa)
	TSC2	TSC complex subunit 2. (1835 aa)
	LOC115498199	Uncharacterized protein. (373 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
	FAS	Uncharacterized protein. (363 aa)
	PERP	Uncharacterized protein. (196 aa)
	MDM4	MDM4 regulator of p53. (471 aa)
	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta. (224 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (309 aa)
	CCNG1	Cyclin G1; Belongs to the cyclin family. (295 aa)
	CASP8	Caspase 8. (480 aa)
	SRSF3	Uncharacterized protein. (242 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (78 aa)
	ZMAT3	Uncharacterized protein. (289 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (333 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (587 aa)
	LOC100221212	Uncharacterized protein. (189 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (190 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (383 aa)
	LOC115491438	Cyclin-dependent kinase 2. (298 aa)
	COP1	COP1 E3 ubiquitin ligase. (711 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (656 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	ATM	ENSTGUP00000009081	ENSTGUP00000013001	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Non-specific serine/threonine protein kinase.	0.482
APAF1	BCL2L1	ENSTGUP00000009081	ENSTGUP00000006866	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.830
APAF1	CASP3	ENSTGUP00000009081	ENSTGUP00000006879	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.948
APAF1	CASP8	ENSTGUP00000009081	ENSTGUP00000030393	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8.	0.884
APAF1	CASP9	ENSTGUP00000009081	ENSTGUP00000017449	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	DDB2	ENSTGUP00000009081	ENSTGUP00000010824	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Damage specific DNA binding protein 2.	0.441
APAF1	LOC100223333	ENSTGUP00000009081	ENSTGUP00000010625	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8.	0.891
APAF1	PIDD1	ENSTGUP00000009081	ENSTGUP00000010130	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	P53-induced death domain protein 1.	0.434
APAF1	TP73	ENSTGUP00000009081	ENSTGUP00000037525	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.531
ATM	APAF1	ENSTGUP00000013001	ENSTGUP00000009081	Non-specific serine/threonine protein kinase.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.482
ATM	ATR	ENSTGUP00000013001	ENSTGUP00000008840	Non-specific serine/threonine protein kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.999
ATM	CASP3	ENSTGUP00000013001	ENSTGUP00000006879	Non-specific serine/threonine protein kinase.	Caspase 3; Belongs to the peptidase C14A family.	0.406
ATM	CDK1	ENSTGUP00000013001	ENSTGUP00000005490	Non-specific serine/threonine protein kinase.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.648
ATM	CDK6	ENSTGUP00000013001	ENSTGUP00000001543	Non-specific serine/threonine protein kinase.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.574
ATM	CHEK1	ENSTGUP00000013001	ENSTGUP00000000812	Non-specific serine/threonine protein kinase.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.983
ATM	CHEK2	ENSTGUP00000013001	ENSTGUP00000008109	Non-specific serine/threonine protein kinase.	Checkpoint kinase 2.	0.995
ATM	COP1	ENSTGUP00000013001	ENSTGUP00000037355	Non-specific serine/threonine protein kinase.	COP1 E3 ubiquitin ligase.	0.714
ATM	LOC115491438	ENSTGUP00000013001	ENSTGUP00000036275	Non-specific serine/threonine protein kinase.	Cyclin-dependent kinase 2.	0.631
ATM	MDM2	ENSTGUP00000013001	ENSTGUP00000022070	Non-specific serine/threonine protein kinase.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.912
ATM	MDM4	ENSTGUP00000013001	ENSTGUP00000023572	Non-specific serine/threonine protein kinase.	MDM4 regulator of p53.	0.818