STRINGSTRING
ADRA1B ADRA1B SCN4B SCN4B TPM4 TPM4 SLC9A1 SLC9A1 CREB3L3 CREB3L3 GNAI3 GNAI3 PPP2CA PPP2CA MAPK13 MAPK13 PPP2CB PPP2CB SLC8A1 SLC8A1 PPP1CB PPP1CB CACNA2D1 CACNA2D1 GNAI1 GNAI1 PIK3CG PIK3CG ATP1B4 ATP1B4 CAMK2B CAMK2B ADCY9 ADCY9 MAPK12 MAPK12 MAPK11 MAPK11 ATP2A3 ATP2A3 ADRA1A ADRA1A PPP2R2A PPP2R2A ADCY5 ADCY5 PRKCA PRKCA CACNG4 CACNG4 CACNG1 CACNG1 ATP2B2 ATP2B2 CACNA2D2 CACNA2D2 PPP2R5D PPP2R5D ATP2A2 ATP2A2 PPP1CA PPP1CA PPP1CC PPP1CC MYL2 MYL2 CACNA2D3 CACNA2D3 PPP2R3A PPP2R3A ADCY1 ADCY1 PLCB2 PLCB2 ADCY2 ADCY2 ATP1B3 ATP1B3 ADCY7 ADCY7 ATF2 ATF2 LOC105758501 LOC105758501 AGT AGT ATF4 ATF4 CREB3L1 CREB3L1 CACNG2 CACNG2 CREB3L2 CREB3L2 LOC100223115 LOC100223115 ACTC1 ACTC1 PPP2R3C PPP2R3C PPP2R5E PPP2R5E PPP2R1A PPP2R1A PRKACB PRKACB LOC100227551 LOC100227551 CACNA2D4 CACNA2D4 PPP2R2C PPP2R2C ADRB1 ADRB1 CACNA1C CACNA1C CREM CREM ENSTGUP00000020975 ENSTGUP00000020975 AKT3 AKT3 CREB1 CREB1 CAMK2A CAMK2A CACNG3 CACNG3 PLCB1 PLCB1 CREB3 CREB3 ATP1A1 ATP1A1 FXYD2 FXYD2 GNAS GNAS CAMK2G CAMK2G ENSTGUP00000024467 ENSTGUP00000024467 ATP2B1 ATP2B1 CACNG5 CACNG5 PPP2R3B PPP2R3B KCNQ1 KCNQ1 TPM1 TPM1 H1A0E2_TAEGU H1A0E2_TAEGU ADCY6 ADCY6 PLN PLN ADCY8 ADCY8 PPP2R2B PPP2R2B GNAI2 GNAI2 ADRA1D ADRA1D RYR2 RYR2 RAPGEF4 RAPGEF4 RPS6KA5 RPS6KA5 CREB3L4 CREB3L4 ATP1A2 ATP1A2 LOC115491504 LOC115491504 TPM3 TPM3 ATP2A1 ATP2A1 PPP2R5A PPP2R5A SLC8A3 SLC8A3 ATP2B4 ATP2B4 PPP2R5C PPP2R5C PLCB4 PLCB4 CACNA1S CACNA1S MAPK1 MAPK1 AKT1 AKT1 CACNB2 CACNB2 AGTR2 AGTR2 CALM1 CALM1 TNNC1 TNNC1 ADRB2 ADRB2 CACNA1D CACNA1D MYH7 MYH7 AGTR1 AGTR1 CREB5 CREB5 ATP1B1 ATP1B1 MAPK14 MAPK14 CACNB4 CACNB4 LOC100230245 LOC100230245 MYL4 MYL4 CACNB1 CACNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADRA1BAdrenoceptor alpha 1B. (489 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (289 aa)
TPM4Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (803 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (449 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAPK13Mitogen-activated protein kinase. (361 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (933 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CACNA2D1VWFA domain-containing protein. (1085 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (323 aa)
CAMK2BProtein kinase domain-containing protein. (542 aa)
ADCY9Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1347 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (952 aa)
ADRA1AAdrenoceptor alpha 1A. (464 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (481 aa)
ADCY5Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1216 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (226 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1245 aa)
CACNA2D2VGCC_alpha2 domain-containing protein. (1113 aa)
PPP2R5DSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (614 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1043 aa)
PPP1CASerine/threonine-protein phosphatase. (512 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
MYL2Myosin light chain 2. (165 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1103 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1132 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1142 aa)
PLCB2Phosphoinositide phospholipase C. (1306 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1140 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1048 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (485 aa)
LOC105758501EF-hand domain-containing protein. (153 aa)
AGTAngiotensinogen; Belongs to the serpin family. (462 aa)
ATF4Activating transcription factor 4. (354 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (505 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (521 aa)
LOC100223115Protein phosphatase 2 regulatory subunit Bdelta. (455 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
PPP2R3CEF-hand_13 domain-containing protein. (450 aa)
PPP2R5ESerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (516 aa)
PPP2R1AUncharacterized protein. (587 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
LOC100227551Uncharacterized protein. (186 aa)
CACNA2D4VWFA domain-containing protein. (1098 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (502 aa)
ADRB1Beta-1 adrenergic receptor isoform X2. (459 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2148 aa)
CREMcAMP responsive element modulator. (125 aa)
ENSTGUP00000020975LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3-like. (1251 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (533 aa)
CREB1cAMP responsive element binding protein 1. (324 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2. (507 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (401 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
CREB3BZIP domain-containing protein. (428 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1327 aa)
FXYD2Sodium/potassium-transporting ATPase subunit gamma. (78 aa)
GNASGNAS complex locus. (414 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma; Belongs to the protein kinase superfamily. (597 aa)
ENSTGUP00000024467Myosin heavy chain 6/7. (1925 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (279 aa)
PPP2R3BUncharacterized protein. (581 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (691 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
H1A0E2_TAEGUUncharacterized protein. (1815 aa)
ADCY6Guanylate cyclase domain-containing protein. (1156 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1319 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
GNAI2G protein subunit alpha i2. (356 aa)
ADRA1DAdrenoceptor alpha 1D. (511 aa)
RYR2Ryanodine receptor 2. (4939 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1026 aa)
RPS6KA5Ribosomal protein S6 kinase. (784 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (320 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha-2. (1020 aa)
LOC115491504Cyclic nucleotide-binding domain-containing protein. (932 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (294 aa)
ATP2A1Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1. (1187 aa)
PPP2R5ASerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (477 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1338 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (577 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1212 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1849 aa)
MAPK1Mitogen-activated protein kinase. (369 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (651 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CALM1Calmodulin 2; Belongs to the calmodulin family. (243 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (176 aa)
ADRB2Adrenergic receptor beta-2. (402 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (295 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CACNB4SH3 domain-containing protein. (478 aa)
LOC100230245Uncharacterized protein. (359 aa)
MYL4Uncharacterized protein. (203 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (501 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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