(41 nodes) Hedgehog signaling pathway network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSNK1A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
	PTCH1	Patched 1. (1443 aa)
	GAS1	Uncharacterized protein. (159 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (425 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	GLI3	Uncharacterized protein. (1575 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
	HHIP	Hedgehog interacting protein. (723 aa)
	GLI2	Uncharacterized protein. (1528 aa)
	CSNK1G1	Casein kinase 1 gamma 1. (464 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (902 aa)
	GRK3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (949 aa)
	SMURF1	E3 ubiquitin-protein ligase. (737 aa)
	PTCH2	Patched 2. (1310 aa)
	LRP2	LDL receptor related protein 2. (4616 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (768 aa)
	KIF7	Uncharacterized protein. (1360 aa)
	EVC2	EvC ciliary complex subunit 2. (1299 aa)
	EVC	EvC ciliary complex subunit 1. (906 aa)
	SUFU	Suppressor of fused homolog. (482 aa)
	SPOPL	Speckle type BTB/POZ protein like. (392 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	BOC	BOC cell adhesion associated, oncogene regulated. (1106 aa)
	GPR161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (546 aa)
	ARRB1	Arrestin beta 1. (420 aa)
	FBXW11	Uncharacterized protein. (563 aa)
	BTRC	Uncharacterized protein. (667 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
	SPOP	BTB domain-containing protein. (374 aa)
	CDON	Uncharacterized protein. (1245 aa)
	SMURF2	E3 ubiquitin-protein ligase. (777 aa)
	CSNK1G3	Protein kinase domain-containing protein. (451 aa)
	CSNK1G2	Casein kinase 1 gamma 2. (450 aa)
	CSNK1E	Protein kinase domain-containing protein. (482 aa)
	DHH	Desert hedgehog protein isoform X2. (414 aa)
	MGRN1	Mahogunin ring finger 1. (584 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (309 aa)
	GLI1	Uncharacterized protein. (1276 aa)
	IHH	Indian hedgehog signaling molecule. (408 aa)
	CSNK1D	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (415 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	GLI1	ENSTGUP00000013972	ENSTGUP00000031577	Arrestin beta 1.	Uncharacterized protein.	0.910
ARRB1	GLI2	ENSTGUP00000013972	ENSTGUP00000004751	Arrestin beta 1.	Uncharacterized protein.	0.907
ARRB1	GLI3	ENSTGUP00000013972	ENSTGUP00000001895	Arrestin beta 1.	Uncharacterized protein.	0.904
ARRB1	GPR161	ENSTGUP00000013972	ENSTGUP00000013835	Arrestin beta 1.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.931
ARRB1	GRK2	ENSTGUP00000013972	ENSTGUP00000006253	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.952
ARRB1	GRK3	ENSTGUP00000013972	ENSTGUP00000007823	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.867
ARRB1	SMO	ENSTGUP00000013972	ENSTGUP00000001924	Arrestin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.965
BOC	CDON	ENSTGUP00000013815	ENSTGUP00000019770	BOC cell adhesion associated, oncogene regulated.	Uncharacterized protein.	0.955
BOC	DHH	ENSTGUP00000013815	ENSTGUP00000026461	BOC cell adhesion associated, oncogene regulated.	Desert hedgehog protein isoform X2.	0.984
BOC	GAS1	ENSTGUP00000013815	ENSTGUP00000000632	BOC cell adhesion associated, oncogene regulated.	Uncharacterized protein.	0.948
BOC	HHIP	ENSTGUP00000013815	ENSTGUP00000002801	BOC cell adhesion associated, oncogene regulated.	Hedgehog interacting protein.	0.605
BOC	IHH	ENSTGUP00000013815	ENSTGUP00000038054	BOC cell adhesion associated, oncogene regulated.	Indian hedgehog signaling molecule.	0.981
BOC	LRP2	ENSTGUP00000013815	ENSTGUP00000008033	BOC cell adhesion associated, oncogene regulated.	LDL receptor related protein 2.	0.902
BOC	PTCH1	ENSTGUP00000013815	ENSTGUP00000000560	BOC cell adhesion associated, oncogene regulated.	Patched 1.	0.979
BOC	PTCH2	ENSTGUP00000013815	ENSTGUP00000007994	BOC cell adhesion associated, oncogene regulated.	Patched 2.	0.972
BOC	SHH	ENSTGUP00000013815	ENSTGUP00000000707	BOC cell adhesion associated, oncogene regulated.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.981
BOC	SMO	ENSTGUP00000013815	ENSTGUP00000001924	BOC cell adhesion associated, oncogene regulated.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.636
BTRC	CSNK1A1	ENSTGUP00000017175	ENSTGUP00000000252	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.564
BTRC	CSNK1D	ENSTGUP00000017175	ENSTGUP00000038100	Uncharacterized protein.	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	0.663
BTRC	CSNK1E	ENSTGUP00000017175	ENSTGUP00000025663	Uncharacterized protein.	Protein kinase domain-containing protein.	0.663