(104 nodes) Insulin signaling pathway network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MKNK2	MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (470 aa)
	INSR	Insulin receptor. (1323 aa)
	SHC3	SHC adaptor protein 3. (632 aa)
	RHEB	Uncharacterized protein. (254 aa)
	SHC2	PID domain-containing protein. (600 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
	NRAS	NRAS proto-oncogene, GTPase. (280 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (698 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1322 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (1322 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	LOC100222691	SH2 domain-containing protein. (1057 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	SOCS3	Suppressor of cytokine signaling 3. (209 aa)
	GCK	Hexokinase-4 isoform X1. (465 aa)
	FASN	Fatty acid synthase. (2514 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (382 aa)
	SH2B2	SH2B adaptor protein 2. (708 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (117 aa)
	PHKA1	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1207 aa)
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	PYGB	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (835 aa)
	PHKG1	Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (388 aa)
	GINS4	Protein phosphatase 1 regulatory subunit. (523 aa)
	TSC1	Uncharacterized protein. (1175 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	RPS6KB2	Ribosomal protein S6 kinase beta-2 isoform X1. (671 aa)
	PPP1CA	Serine/threonine-protein phosphatase. (512 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2241 aa)
	SHC4	SHC adaptor protein 4. (634 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1120 aa)
	G6PC2	Glucose-6-phosphatase catalytic subunit 2. (154 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
	PHKA2	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1191 aa)
	IRS1	Insulin receptor substrate 1. (1233 aa)
	LOC100221185	Uncharacterized protein. (738 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	MKNK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
	PDE3B	Phosphodiesterase. (1112 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (314 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
	GRB2	Putative growth factor receptor-bound protein 2. (217 aa)
	IRS2	Insulin receptor substrate 2. (1192 aa)
	PRKAR2A	Uncharacterized protein. (399 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (273 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (137 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (399 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	LOC105758501	EF-hand domain-containing protein. (153 aa)
	HRAS	Putative v-Ha-ras Harvey sarcoma viral oncogene variant 2. (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (765 aa)
	FOXO1	Forkhead box O1. (785 aa)
	GYS2	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (771 aa)
	PYGL	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (855 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	CBLB	Cbl proto-oncogene B. (1025 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type 1. (432 aa)
	MAPK10	Mitogen-activated protein kinase. (472 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
	HK1	Hexokinase 1. (927 aa)
	SHC1	SHC adaptor protein 1. (609 aa)
	FLOT1	Flotillin-1. (451 aa)
	INPPL1	Uncharacterized protein. (1323 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
	PIK3R2	Uncharacterized protein. (727 aa)
	G6PC3	Glucose-6-phosphatase 3 isoform X1. (351 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (533 aa)
	PIK3CB	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	TSC2	TSC complex subunit 2. (1835 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2345 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (591 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (1062 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (301 aa)
	HK2	Hexokinase 2. (917 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (254 aa)
	SOCS4	Suppressor of cytokine signaling 4. (436 aa)
	PPP1R3A	CBM21 domain-containing protein. (1121 aa)
	IRS4	Uncharacterized protein. (1150 aa)
	CRK	Uncharacterized protein. (305 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	CRKL	Uncharacterized protein. (303 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (555 aa)
	PRKAG1	5'-AMP-activated protein kinase, regulatory gamma subunit. (296 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1877 aa)
	MAPK1	Mitogen-activated protein kinase. (369 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (412 aa)
	PPP1R3E	Protein phosphatase 1 regulatory subunit 3A/B/C/D/E. (301 aa)
	CALM1	Calmodulin 2; Belongs to the calmodulin family. (243 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (561 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (400 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (807 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (470 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit 3D. (306 aa)
	PHKB	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1092 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	KRAS	GTPase KRas. (217 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSTGUP00000022961	ENSTGUP00000007445	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.901
ACACA	FASN	ENSTGUP00000022961	ENSTGUP00000003991	Acetyl-CoA carboxylase alpha.	Fatty acid synthase.	0.966
ACACA	PRKAA1	ENSTGUP00000022961	ENSTGUP00000033501	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.926
ACACA	PRKAA2	ENSTGUP00000022961	ENSTGUP00000009883	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.926
ACACA	PRKAB1	ENSTGUP00000022961	ENSTGUP00000009543	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit beta 1.	0.915
ACACA	PRKAB2	ENSTGUP00000022961	ENSTGUP00000034132	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.913
ACACA	PRKAG1	ENSTGUP00000022961	ENSTGUP00000029994	Acetyl-CoA carboxylase alpha.	5'-AMP-activated protein kinase, regulatory gamma subunit.	0.909
ACACA	PRKAG2	ENSTGUP00000022961	ENSTGUP00000000615	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.909
ACACA	PRKAG3	ENSTGUP00000022961	ENSTGUP00000033809	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.909
ACACA	SREBF1	ENSTGUP00000022961	ENSTGUP00000007557	Acetyl-CoA carboxylase alpha.	Sterol regulatory element binding transcription factor 1.	0.499
ACACB	ACACA	ENSTGUP00000007445	ENSTGUP00000022961	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.901
ACACB	FASN	ENSTGUP00000007445	ENSTGUP00000003991	Acetyl-CoA carboxylase beta.	Fatty acid synthase.	0.954
ACACB	PRKAA1	ENSTGUP00000007445	ENSTGUP00000033501	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.926
ACACB	PRKAA2	ENSTGUP00000007445	ENSTGUP00000009883	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.926
ACACB	PRKAB1	ENSTGUP00000007445	ENSTGUP00000009543	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 1.	0.915
ACACB	PRKAB2	ENSTGUP00000007445	ENSTGUP00000034132	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.913
ACACB	PRKAG1	ENSTGUP00000007445	ENSTGUP00000029994	Acetyl-CoA carboxylase beta.	5'-AMP-activated protein kinase, regulatory gamma subunit.	0.909
ACACB	PRKAG2	ENSTGUP00000007445	ENSTGUP00000000615	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.909
ACACB	PRKAG3	ENSTGUP00000007445	ENSTGUP00000033809	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.909
AKT1	AKT3	ENSTGUP00000031570	ENSTGUP00000021438	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901