(38 nodes) Transcription elongation factor complex, and RNA polymerase II CTD heptapeptide repeat kinase activity network (Agaricus bisporus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	K5VL85_AGABU	Uncharacterized protein. (203 aa)
	K5VNB3_AGABU	Uncharacterized protein. (916 aa)
	K5VTD2_AGABU	Uncharacterized protein. (428 aa)
	K5VVJ4_AGABU	Plus3 domain-containing protein. (520 aa)
	K5W1N4_AGABU	Uncharacterized protein. (1346 aa)
	K5WK63_AGABU	Protein kinase domain-containing protein. (574 aa)
	K5WNX6_AGABU	Uncharacterized protein. (539 aa)
	K5WQ49_AGABU	Protein kinase domain-containing protein. (380 aa)
	K5WT98_AGABU	Uncharacterized protein. (602 aa)
	K5WTY7_AGABU	Uncharacterized protein. (106 aa)
	K5WUH3_AGABU	Spt5-NGN domain-containing protein. (440 aa)
	K5WUX7_AGABU	mRNA_triPase domain-containing protein. (291 aa)
	K5WY59_AGABU	CID domain-containing protein. (271 aa)
	K5WYF1_AGABU	Uncharacterized protein. (336 aa)
	K5WYM2_AGABU	Uncharacterized protein. (1087 aa)
	K5X196_AGABU	Uncharacterized protein. (382 aa)
	K5X3G8_AGABU	Uncharacterized protein. (948 aa)
	K5X3H4_AGABU	Uncharacterized protein. (401 aa)
	K5X3Q1_AGABU	mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family. (452 aa)
	K5X4Q2_AGABU	Uncharacterized protein. (848 aa)
	K5X5M6_AGABU	Uncharacterized protein. (1217 aa)
	K5X746_AGABU	Uncharacterized protein. (336 aa)
	K5XA39_AGABU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (331 aa)
	K5XAP5_AGABU	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (427 aa)
	K5XE97_AGABU	Uncharacterized protein. (433 aa)
	K5XFW9_AGABU	EAF domain-containing protein. (476 aa)
	K5XGS5_AGABU	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1427 aa)
	K5XGS8_AGABU	Uncharacterized protein. (315 aa)
	K5XIY9_AGABU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
	K5XJX1_AGABU	Uncharacterized protein. (237 aa)
	K5XKR3_AGABU	Uncharacterized protein. (716 aa)
	K5XS56_AGABU	Uncharacterized protein; Belongs to the SKP1 family. (114 aa)
	K5XTH0_AGABU	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (1130 aa)
	K5XTJ8_AGABU	CDC73_C domain-containing protein. (407 aa)
	K5XU83_AGABU	TFIIS N-terminal domain-containing protein. (376 aa)
	K5XVN9_AGABU	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (684 aa)
	K5Y3Z0_AGABU	Uncharacterized protein; Belongs to the cyclin family. (331 aa)
	K5Y4A1_AGABU	Uncharacterized protein. (1061 aa)

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VL85_AGABU	K5VTD2_AGABU	K5VL85	K5VTD2	Uncharacterized protein.	Uncharacterized protein.	0.605
K5VL85_AGABU	K5WUH3_AGABU	K5VL85	K5WUH3	Uncharacterized protein.	Spt5-NGN domain-containing protein.	0.605
K5VL85_AGABU	K5X5M6_AGABU	K5VL85	K5X5M6	Uncharacterized protein.	Uncharacterized protein.	0.605
K5VL85_AGABU	K5XKR3_AGABU	K5VL85	K5XKR3	Uncharacterized protein.	Uncharacterized protein.	0.605
K5VL85_AGABU	K5XTH0_AGABU	K5VL85	K5XTH0	Uncharacterized protein.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.605
K5VL85_AGABU	K5XVN9_AGABU	K5VL85	K5XVN9	Uncharacterized protein.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.602
K5VL85_AGABU	K5Y3Z0_AGABU	K5VL85	K5Y3Z0	Uncharacterized protein.	Uncharacterized protein; Belongs to the cyclin family.	0.622
K5VNB3_AGABU	K5WK63_AGABU	K5VNB3	K5WK63	Uncharacterized protein.	Protein kinase domain-containing protein.	0.401
K5VNB3_AGABU	K5X3Q1_AGABU	K5VNB3	K5X3Q1	Uncharacterized protein.	mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family.	0.430
K5VNB3_AGABU	K5XA39_AGABU	K5VNB3	K5XA39	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.401
K5VNB3_AGABU	K5XGS5_AGABU	K5VNB3	K5XGS5	Uncharacterized protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.413
K5VNB3_AGABU	K5Y4A1_AGABU	K5VNB3	K5Y4A1	Uncharacterized protein.	Uncharacterized protein.	0.497
K5VTD2_AGABU	K5VL85_AGABU	K5VTD2	K5VL85	Uncharacterized protein.	Uncharacterized protein.	0.605
K5VTD2_AGABU	K5VVJ4_AGABU	K5VTD2	K5VVJ4	Uncharacterized protein.	Plus3 domain-containing protein.	0.711
K5VTD2_AGABU	K5W1N4_AGABU	K5VTD2	K5W1N4	Uncharacterized protein.	Uncharacterized protein.	0.512
K5VTD2_AGABU	K5WK63_AGABU	K5VTD2	K5WK63	Uncharacterized protein.	Protein kinase domain-containing protein.	0.684
K5VTD2_AGABU	K5WT98_AGABU	K5VTD2	K5WT98	Uncharacterized protein.	Uncharacterized protein.	0.528
K5VTD2_AGABU	K5WUX7_AGABU	K5VTD2	K5WUX7	Uncharacterized protein.	mRNA_triPase domain-containing protein.	0.486
K5VTD2_AGABU	K5WYM2_AGABU	K5VTD2	K5WYM2	Uncharacterized protein.	Uncharacterized protein.	0.723
K5VTD2_AGABU	K5X196_AGABU	K5VTD2	K5X196	Uncharacterized protein.	Uncharacterized protein.	0.492