(30 nodes) Exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5-phosphomonoesters network (Agaricus bisporus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	K5Y6K2_AGABU	Endo/exonuclease/phosphatase domain-containing protein. (438 aa)
	K5VMF2_AGABU	Exonuclease domain-containing protein. (567 aa)
	K5VQK1_AGABU	Uncharacterized protein. (320 aa)
	K5W0X3_AGABU	CCHC-type domain-containing protein. (315 aa)
	K5W3Y3_AGABU	DRMBL domain-containing protein. (866 aa)
	K5W7Y3_AGABU	Exonuclease domain-containing protein. (416 aa)
	K5WAW9_AGABU	Uncharacterized protein. (525 aa)
	K5Y5Q7_AGABU	3'-5' exonuclease domain-containing protein. (374 aa)
	K5Y267_AGABU	DNA polymerase. (1089 aa)
	K5XSY3_AGABU	RNB domain-containing protein. (831 aa)
	K5XRW0_AGABU	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2236 aa)
	K5XK70_AGABU	Uncharacterized protein. (331 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1119 aa)
	K5XGZ6_AGABU	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (326 aa)
	K5XFR4_AGABU	Endo/exonuclease/phosphatase domain-containing protein. (641 aa)
	K5XEA1_AGABU	Uncharacterized protein. (456 aa)
	K5XB02_AGABU	XRN_M domain-containing protein. (345 aa)
	K5X8K3_AGABU	Uncharacterized protein. (320 aa)
	K5X8H1_AGABU	Uncharacterized protein. (293 aa)
	K5X7R0_AGABU	Uncharacterized protein. (569 aa)
	K5X6P9_AGABU	Uncharacterized protein. (81 aa)
	K5X012_AGABU	Exonuclease domain-containing protein. (189 aa)
	K5WXI4_AGABU	HRDC domain-containing protein. (882 aa)
	K5WXA7_AGABU	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (1257 aa)
	K5WWJ6_AGABU	Endo/exonuclease/phosphatase domain-containing protein. (607 aa)
	K5WWH5_AGABU	Uncharacterized protein; Belongs to the RNR ribonuclease family. (995 aa)
	K5WUK8_AGABU	Uncharacterized protein. (345 aa)
	K5WT04_AGABU	3'-5' exonuclease domain-containing protein. (415 aa)
	K5WSG5_AGABU	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (731 aa)
	K5WMD0_AGABU	zf-C2HE domain-containing protein. (263 aa)

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VMF2_AGABU	K5WWH5_AGABU	K5VMF2	K5WWH5	Exonuclease domain-containing protein.	Uncharacterized protein; Belongs to the RNR ribonuclease family.	0.441
K5VMF2_AGABU	K5WXA7_AGABU	K5VMF2	K5WXA7	Exonuclease domain-containing protein.	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	0.403
K5VMF2_AGABU	K5X012_AGABU	K5VMF2	K5X012	Exonuclease domain-containing protein.	Exonuclease domain-containing protein.	0.959
K5VQK1_AGABU	K5W3Y3_AGABU	K5VQK1	K5W3Y3	Uncharacterized protein.	DRMBL domain-containing protein.	0.522
K5VQK1_AGABU	K5WMD0_AGABU	K5VQK1	K5WMD0	Uncharacterized protein.	zf-C2HE domain-containing protein.	0.551
K5VQK1_AGABU	K5WSG5_AGABU	K5VQK1	K5WSG5	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.984
K5VQK1_AGABU	K5WT04_AGABU	K5VQK1	K5WT04	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.987
K5VQK1_AGABU	K5X012_AGABU	K5VQK1	K5X012	Uncharacterized protein.	Exonuclease domain-containing protein.	0.448
K5VQK1_AGABU	K5X8H1_AGABU	K5VQK1	K5X8H1	Uncharacterized protein.	Uncharacterized protein.	0.806
K5VQK1_AGABU	K5XEA1_AGABU	K5VQK1	K5XEA1	Uncharacterized protein.	Uncharacterized protein.	0.585
K5VQK1_AGABU	K5XFR4_AGABU	K5VQK1	K5XFR4	Uncharacterized protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.629
K5VQK1_AGABU	K5XGZ6_AGABU	K5VQK1	K5XGZ6	Uncharacterized protein.	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.629
K5VQK1_AGABU	K5XRW0_AGABU	K5VQK1	K5XRW0	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.848
K5VQK1_AGABU	K5Y267_AGABU	K5VQK1	K5Y267	Uncharacterized protein.	DNA polymerase.	0.873
K5VQK1_AGABU	K5Y5Q7_AGABU	K5VQK1	K5Y5Q7	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.987
K5W0X3_AGABU	K5WWH5_AGABU	K5W0X3	K5WWH5	CCHC-type domain-containing protein.	Uncharacterized protein; Belongs to the RNR ribonuclease family.	0.405
K5W0X3_AGABU	K5X7R0_AGABU	K5W0X3	K5X7R0	CCHC-type domain-containing protein.	Uncharacterized protein.	0.976
K5W0X3_AGABU	K5XB02_AGABU	K5W0X3	K5XB02	CCHC-type domain-containing protein.	XRN_M domain-containing protein.	0.946
K5W3Y3_AGABU	K5VQK1_AGABU	K5W3Y3	K5VQK1	DRMBL domain-containing protein.	Uncharacterized protein.	0.522
K5W3Y3_AGABU	K5WSG5_AGABU	K5W3Y3	K5WSG5	DRMBL domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.739