(15 nodes) Regulation of transcription elongation from RNA polymerase II promoter network (Agaricus bisporus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	K5W576_AGABU	Uncharacterized protein. (296 aa)
	K5W4U4_AGABU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (370 aa)
	K5XME3_AGABU	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (118 aa)
	K5XTJ8_AGABU	CDC73_C domain-containing protein. (407 aa)
	K5XP64_AGABU	AAA domain-containing protein; Belongs to the AAA ATPase family. (402 aa)
	K5WK63_AGABU	Protein kinase domain-containing protein. (574 aa)
	K5VVJ4_AGABU	Plus3 domain-containing protein. (520 aa)
	K5W0X3_AGABU	CCHC-type domain-containing protein. (315 aa)
	K5W4G4_AGABU	AAA domain-containing protein; Belongs to the AAA ATPase family. (399 aa)
	K5Y4A1_AGABU	Uncharacterized protein. (1061 aa)
	K5WXQ3_AGABU	Uncharacterized protein. (649 aa)
	K5XA39_AGABU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (331 aa)
	K5XB02_AGABU	XRN_M domain-containing protein. (345 aa)
	K5XGS5_AGABU	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1427 aa)
	K5XK47_AGABU	Uncharacterized protein. (151 aa)

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VVJ4_AGABU	K5XGS5_AGABU	K5VVJ4	K5XGS5	Plus3 domain-containing protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.939
K5VVJ4_AGABU	K5XME3_AGABU	K5VVJ4	K5XME3	Plus3 domain-containing protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.939
K5VVJ4_AGABU	K5XTJ8_AGABU	K5VVJ4	K5XTJ8	Plus3 domain-containing protein.	CDC73_C domain-containing protein.	0.997
K5VVJ4_AGABU	K5Y4A1_AGABU	K5VVJ4	K5Y4A1	Plus3 domain-containing protein.	Uncharacterized protein.	0.974
K5W0X3_AGABU	K5XB02_AGABU	K5W0X3	K5XB02	CCHC-type domain-containing protein.	XRN_M domain-containing protein.	0.946
K5W4G4_AGABU	K5XP64_AGABU	K5W4G4	K5XP64	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
K5W4U4_AGABU	K5WK63_AGABU	K5W4U4	K5WK63	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.756
K5W4U4_AGABU	K5WXQ3_AGABU	K5W4U4	K5WXQ3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.838
K5W4U4_AGABU	K5XA39_AGABU	K5W4U4	K5XA39	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.755
K5W4U4_AGABU	K5XME3_AGABU	K5W4U4	K5XME3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.870
K5W4U4_AGABU	K5Y4A1_AGABU	K5W4U4	K5Y4A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.666
K5WK63_AGABU	K5W4U4_AGABU	K5WK63	K5W4U4	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.756
K5WK63_AGABU	K5XA39_AGABU	K5WK63	K5XA39	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.491
K5WK63_AGABU	K5XGS5_AGABU	K5WK63	K5XGS5	Protein kinase domain-containing protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.537
K5WK63_AGABU	K5XME3_AGABU	K5WK63	K5XME3	Protein kinase domain-containing protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.813
K5WK63_AGABU	K5XTJ8_AGABU	K5WK63	K5XTJ8	Protein kinase domain-containing protein.	CDC73_C domain-containing protein.	0.521
K5WK63_AGABU	K5Y4A1_AGABU	K5WK63	K5Y4A1	Protein kinase domain-containing protein.	Uncharacterized protein.	0.723
K5WXQ3_AGABU	K5W4U4_AGABU	K5WXQ3	K5W4U4	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.838
K5WXQ3_AGABU	K5XME3_AGABU	K5WXQ3	K5XME3	Uncharacterized protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.722
K5WXQ3_AGABU	K5Y4A1_AGABU	K5WXQ3	K5Y4A1	Uncharacterized protein.	Uncharacterized protein.	0.674