(100 nodes) Microtubule cytoskeleton network (Agaricus bisporus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	K5VKN7_AGABU	Spindle pole body component. (984 aa)
	K5VM58_AGABU	Uncharacterized protein. (247 aa)
	K5VMR8_AGABU	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1600 aa)
	K5VSJ3_AGABU	Uncharacterized protein. (273 aa)
	K5VTA4_AGABU	Uncharacterized protein. (219 aa)
	K5VXN9_AGABU	Uncharacterized protein. (660 aa)
	K5VXW7_AGABU	Uncharacterized protein. (517 aa)
	K5VYT8_AGABU	Uncharacterized protein. (310 aa)
	K5VZM6_AGABU	Uncharacterized protein. (444 aa)
	K5W404_AGABU	Uncharacterized protein. (189 aa)
	K5W4A5_AGABU	Uncharacterized protein. (239 aa)
	K5W4W7_AGABU	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (76 aa)
	K5W9W8_AGABU	Uncharacterized protein. (3415 aa)
	K5WAH9_AGABU	Nudix hydrolase domain-containing protein. (693 aa)
	K5WAL4_AGABU	Uncharacterized protein. (660 aa)
	K5WJ64_AGABU	Peptidase C50 domain-containing protein. (1697 aa)
	K5WNC2_AGABU	Uncharacterized protein. (92 aa)
	K5WPQ3_AGABU	DUF155 domain-containing protein. (404 aa)
	K5WQ37_AGABU	Uncharacterized protein. (479 aa)
	K5WQ71_AGABU	Ubiquitin carboxyl-terminal hydrolase. (820 aa)
	K5WTC1_AGABU	Uncharacterized protein; Belongs to the actin family. (618 aa)
	K5WUM1_AGABU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (409 aa)
	K5WV82_AGABU	Uncharacterized protein. (172 aa)
	K5WW03_AGABU	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (870 aa)
	K5WWV6_AGABU	Uncharacterized protein. (732 aa)
	K5WX38_AGABU	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	K5WX70_AGABU	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (810 aa)
	K5WXF5_AGABU	Cnn_1N domain-containing protein. (1002 aa)
	K5WXQ1_AGABU	Uncharacterized protein. (450 aa)
	K5WXZ3_AGABU	Alpha-L-AF_C domain-containing protein. (649 aa)
	K5WYB7_AGABU	Uncharacterized protein. (1240 aa)
	K5WZ82_AGABU	Uncharacterized protein. (411 aa)
	K5WZG7_AGABU	Uncharacterized protein. (501 aa)
	K5WZJ4_AGABU	Uncharacterized protein. (233 aa)
	K5X178_AGABU	CAP-Gly domain-containing protein. (202 aa)
	K5X1H5_AGABU	Uncharacterized protein. (211 aa)
	K5X1P7_AGABU	Uncharacterized protein. (161 aa)
	K5X305_AGABU	Uncharacterized protein. (330 aa)
	K5X310_AGABU	UBIQUITIN_CONJUGAT_2 domain-containing protein. (267 aa)
	K5X338_AGABU	DUF155 domain-containing protein. (111 aa)
	K5X398_AGABU	Uncharacterized protein. (759 aa)
	K5X3C6_AGABU	Uncharacterized protein. (1160 aa)
	K5X4H4_AGABU	Uncharacterized protein. (1128 aa)
	K5X4L2_AGABU	GFA domain-containing protein. (150 aa)
	K5X600_AGABU	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (393 aa)
	K5X621_AGABU	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2014 aa)
	K5X635_AGABU	Uncharacterized protein. (209 aa)
	K5X6U4_AGABU	Uncharacterized protein. (1119 aa)
	K5X6Z6_AGABU	Uncharacterized protein. (333 aa)
	K5X7W5_AGABU	Uncharacterized protein. (568 aa)
	K5X833_AGABU	Protein kinase domain-containing protein. (1263 aa)
	K5X8J4_AGABU	Uncharacterized protein. (96 aa)
	K5X8Q1_AGABU	CAP-Gly domain-containing protein. (1279 aa)
	K5X9F0_AGABU	GFA domain-containing protein. (163 aa)
	K5X9S5_AGABU	Uncharacterized protein; Belongs to the peptidase S10 family. (602 aa)
	K5XAA2_AGABU	Uncharacterized protein. (183 aa)
	K5XAN1_AGABU	Spindle pole body component. (843 aa)
	K5XB19_AGABU	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
	K5XBH6_AGABU	Uncharacterized protein. (1069 aa)
	K5XC59_AGABU	CAP-Gly domain-containing protein. (1055 aa)
	K5XCG4_AGABU	Uncharacterized protein. (111 aa)
	K5XDL5_AGABU	DUF4203 domain-containing protein. (288 aa)
	K5XDU7_AGABU	TOG domain-containing protein. (2557 aa)
	K5XDV6_AGABU	Uncharacterized protein. (176 aa)
	K5XEF9_AGABU	Uncharacterized protein. (1931 aa)
	K5XF75_AGABU	Uncharacterized protein. (2236 aa)
	K5XFC6_AGABU	WD_REPEATS_REGION domain-containing protein. (691 aa)
	PAC1	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (437 aa)
	K5XHC8_AGABU	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (946 aa)
	K5XHS1_AGABU	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (454 aa)
	K5XJ66_AGABU	HORMA domain-containing protein. (207 aa)
	K5XJS0_AGABU	Uncharacterized protein. (883 aa)
	K5XJS2_AGABU	DHC_N1 domain-containing protein. (1184 aa)
	K5XJU0_AGABU	Uncharacterized protein. (686 aa)
	K5XL31_AGABU	Spindle pole body component. (712 aa)
	K5XL89_AGABU	Uncharacterized protein. (184 aa)
	K5XNS0_AGABU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (291 aa)
	K5XPV6_AGABU	PNPLA domain-containing protein. (1002 aa)
	K5XQY0_AGABU	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (636 aa)
	K5XRX2_AGABU	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	K5XS07_AGABU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (291 aa)
	K5XS34_AGABU	Serine/threonine-protein kinase. (928 aa)
	K5XT77_AGABU	GH16 domain-containing protein. (326 aa)
	K5XU91_AGABU	Uncharacterized protein. (382 aa)
	K5XX93_AGABU	Uncharacterized protein. (558 aa)
	K5XXT4_AGABU	RRM domain-containing protein. (218 aa)
	K5XZF1_AGABU	Rab-GAP TBC domain-containing protein. (309 aa)
	K5XZG4_AGABU	Uncharacterized protein. (427 aa)
	K5XZK7_AGABU	TOG domain-containing protein. (549 aa)
	K5XZM2_AGABU	Uncharacterized protein. (558 aa)
	K5Y2M7_AGABU	Uncharacterized protein. (237 aa)
	K5Y377_AGABU	Uncharacterized protein. (751 aa)
	K5Y3C0_AGABU	Uncharacterized protein. (177 aa)
	K5Y3W0_AGABU	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1157 aa)
	K5Y3Z5_AGABU	Uncharacterized protein. (2141 aa)
	K5Y5T5_AGABU	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (977 aa)
	K5Y6I5_AGABU	NUDE_C domain-containing protein. (632 aa)
	K5Y6S1_AGABU	INCENP_ARK-bind domain-containing protein. (1122 aa)
	K5Y7Q6_AGABU	Uncharacterized protein. (167 aa)
	K5Y7S9_AGABU	TPX2 domain-containing protein. (405 aa)

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VKN7_AGABU	K5VSJ3_AGABU	K5VKN7	K5VSJ3	Spindle pole body component.	Uncharacterized protein.	0.810
K5VKN7_AGABU	K5X3C6_AGABU	K5VKN7	K5X3C6	Spindle pole body component.	Uncharacterized protein.	0.991
K5VKN7_AGABU	K5XAA2_AGABU	K5VKN7	K5XAA2	Spindle pole body component.	Uncharacterized protein.	0.835
K5VKN7_AGABU	K5XAN1_AGABU	K5VKN7	K5XAN1	Spindle pole body component.	Spindle pole body component.	0.988
K5VKN7_AGABU	K5XHS1_AGABU	K5VKN7	K5XHS1	Spindle pole body component.	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	0.973
K5VKN7_AGABU	K5XL31_AGABU	K5VKN7	K5XL31	Spindle pole body component.	Spindle pole body component.	0.994
K5VKN7_AGABU	K5Y377_AGABU	K5VKN7	K5Y377	Spindle pole body component.	Uncharacterized protein.	0.734
K5VKN7_AGABU	K5Y3W0_AGABU	K5VKN7	K5Y3W0	Spindle pole body component.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.439
K5VM58_AGABU	K5W9W8_AGABU	K5VM58	K5W9W8	Uncharacterized protein.	Uncharacterized protein.	0.496
K5VM58_AGABU	K5WJ64_AGABU	K5VM58	K5WJ64	Uncharacterized protein.	Peptidase C50 domain-containing protein.	0.621
K5VM58_AGABU	K5WUM1_AGABU	K5VM58	K5WUM1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.890
K5VM58_AGABU	K5WW03_AGABU	K5VM58	K5WW03	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.926
K5VM58_AGABU	K5WX38_AGABU	K5VM58	K5WX38	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.978
K5VM58_AGABU	K5WX70_AGABU	K5VM58	K5WX70	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.723
K5VM58_AGABU	K5WXQ1_AGABU	K5VM58	K5WXQ1	Uncharacterized protein.	Uncharacterized protein.	0.496
K5VM58_AGABU	K5WYB7_AGABU	K5VM58	K5WYB7	Uncharacterized protein.	Uncharacterized protein.	0.631
K5VM58_AGABU	K5WZ82_AGABU	K5VM58	K5WZ82	Uncharacterized protein.	Uncharacterized protein.	0.687
K5VM58_AGABU	K5X398_AGABU	K5VM58	K5X398	Uncharacterized protein.	Uncharacterized protein.	0.680
K5VM58_AGABU	K5X3C6_AGABU	K5VM58	K5X3C6	Uncharacterized protein.	Uncharacterized protein.	0.442
K5VM58_AGABU	K5X6Z6_AGABU	K5VM58	K5X6Z6	Uncharacterized protein.	Uncharacterized protein.	0.420