(42 nodes) Tryptophan metabolism network (Agaricus bisporus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	K5VK66_AGABU	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (526 aa)
	K5VKB7_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (504 aa)
	K5VLQ1_AGABU	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (527 aa)
	K5VSR3_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (501 aa)
	K5VT68_AGABU	Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
	K5VVC1_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (534 aa)
	K5VWW4_AGABU	Aminotran_1_2 domain-containing protein. (460 aa)
	K5W3S9_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (504 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (445 aa)
	K5WJ18_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (506 aa)
	K5WQM7_AGABU	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
	K5WUB1_AGABU	Uncharacterized protein. (552 aa)
	K5WW32_AGABU	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (519 aa)
	K5WWP9_AGABU	Transket_pyr domain-containing protein. (951 aa)
	K5WZ39_AGABU	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (297 aa)
	K5X036_AGABU	Uncharacterized protein. (420 aa)
	K5X2H6_AGABU	Lipoyl-binding domain-containing protein. (432 aa)
	K5X3G1_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (500 aa)
	K5X3J1_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (503 aa)
	K5X3K2_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (507 aa)
	K5X3K8_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (502 aa)
	K5X5H2_AGABU	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (746 aa)
	K5X6Y0_AGABU	Aminotran_1_2 domain-containing protein. (455 aa)
	K5X7S5_AGABU	Uncharacterized protein. (447 aa)
	K5X8L3_AGABU	Dihydrolipoyl dehydrogenase. (508 aa)
	K5XBA3_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (505 aa)
	K5XCC6_AGABU	Uncharacterized protein. (516 aa)
	K5XDL6_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (502 aa)
	K5XFE9_AGABU	CN hydrolase domain-containing protein. (339 aa)
	K5XG22_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (508 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (502 aa)
	K5XH36_AGABU	Uncharacterized protein. (462 aa)
	K5XIG6_AGABU	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (742 aa)
	K5XJT2_AGABU	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (491 aa)
	K5XRJ5_AGABU	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (502 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (174 aa)
	K5XTB6_AGABU	Amidase domain-containing protein. (566 aa)
	K5XV58_AGABU	Uncharacterized protein. (496 aa)
	K5XXY6_AGABU	Aminotran_1_2 domain-containing protein. (432 aa)
	K5XY93_AGABU	Aminotran_1_2 domain-containing protein. (534 aa)
	K5XYC4_AGABU	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (411 aa)
	K5Y254_AGABU	Amidase domain-containing protein. (554 aa)

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	K5XRP7	K5XH30	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.878
BNA1	BNA5	K5XRP7	K5W7D8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.989
BNA1	K5WW32_AGABU	K5XRP7	K5WW32	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.910
BNA1	K5X5H2_AGABU	K5XRP7	K5X5H2	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	0.910
BNA1	K5XIG6_AGABU	K5XRP7	K5XIG6	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	0.910
BNA4	BNA1	K5XH30	K5XRP7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.878
BNA4	BNA5	K5XH30	K5W7D8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.996
BNA4	K5XXY6_AGABU	K5XH30	K5XXY6	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.966
BNA5	BNA1	K5W7D8	K5XRP7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.989
BNA5	BNA4	K5W7D8	K5XH30	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.996
BNA5	K5WUB1_AGABU	K5W7D8	K5WUB1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.930
BNA5	K5WW32_AGABU	K5W7D8	K5WW32	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.906
BNA5	K5X5H2_AGABU	K5W7D8	K5X5H2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	0.906
BNA5	K5X7S5_AGABU	K5W7D8	K5X7S5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.930
BNA5	K5XH36_AGABU	K5W7D8	K5XH36	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.930
BNA5	K5XIG6_AGABU	K5W7D8	K5XIG6	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	0.906
BNA5	K5XV58_AGABU	K5W7D8	K5XV58	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.930
BNA5	K5XXY6_AGABU	K5W7D8	K5XXY6	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminotran_1_2 domain-containing protein.	0.968
K5VK66_AGABU	K5X2H6_AGABU	K5VK66	K5X2H6	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Lipoyl-binding domain-containing protein.	0.400
K5VK66_AGABU	K5XFE9_AGABU	K5VK66	K5XFE9	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	CN hydrolase domain-containing protein.	0.909