(18 nodes) Propanoate metabolism network (Agaricus bisporus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	K5VW61_AGABU	MaoC-like domain-containing protein. (876 aa)
	K5W6P2_AGABU	Transket_pyr domain-containing protein. (343 aa)
	K5WJB4_AGABU	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (677 aa)
	K5WPV1_AGABU	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (685 aa)
	K5WS49_AGABU	Acetyl-coenzyme A synthetase. (662 aa)
	K5WWH0_AGABU	Uncharacterized protein. (335 aa)
	K5WZ39_AGABU	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (297 aa)
	K5X2G9_AGABU	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (530 aa)
	K5X3Y0_AGABU	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (483 aa)
	K5X6D2_AGABU	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (415 aa)
	K5X7Q0_AGABU	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (442 aa)
	K5X8L3_AGABU	Dihydrolipoyl dehydrogenase. (508 aa)
	K5XBN8_AGABU	Uncharacterized protein. (481 aa)
	K5XGM2_AGABU	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (489 aa)
	K5XJ46_AGABU	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (330 aa)
	K5XRW3_AGABU	Uncharacterized protein. (563 aa)
	K5XYC4_AGABU	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (411 aa)
	K5Y601_AGABU	Aldedh domain-containing protein. (546 aa)

Your Current Organism:

Agaricus bisporus

NCBI taxonomy Id: 597362
Other names: A. bisporus var. burnettii JB137-S8, Agaricus bisporus var. burnettii JB137-S8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
K5VW61_AGABU	K5WJB4_AGABU	K5VW61	K5WJB4	MaoC-like domain-containing protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.974
K5VW61_AGABU	K5WPV1_AGABU	K5VW61	K5WPV1	MaoC-like domain-containing protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.974
K5VW61_AGABU	K5WS49_AGABU	K5VW61	K5WS49	MaoC-like domain-containing protein.	Acetyl-coenzyme A synthetase.	0.572
K5VW61_AGABU	K5WZ39_AGABU	K5VW61	K5WZ39	MaoC-like domain-containing protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.966
K5VW61_AGABU	K5XGM2_AGABU	K5VW61	K5XGM2	MaoC-like domain-containing protein.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.954
K5VW61_AGABU	K5XRW3_AGABU	K5VW61	K5XRW3	MaoC-like domain-containing protein.	Uncharacterized protein.	0.966
K5VW61_AGABU	K5XYC4_AGABU	K5VW61	K5XYC4	MaoC-like domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.551
K5W6P2_AGABU	K5X2G9_AGABU	K5W6P2	K5X2G9	Transket_pyr domain-containing protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.995
K5W6P2_AGABU	K5X6D2_AGABU	K5W6P2	K5X6D2	Transket_pyr domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.484
K5W6P2_AGABU	K5X7Q0_AGABU	K5W6P2	K5X7Q0	Transket_pyr domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
K5W6P2_AGABU	K5X8L3_AGABU	K5W6P2	K5X8L3	Transket_pyr domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.995
K5W6P2_AGABU	K5XJ46_AGABU	K5W6P2	K5XJ46	Transket_pyr domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.642
K5W6P2_AGABU	K5XYC4_AGABU	K5W6P2	K5XYC4	Transket_pyr domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.499
K5WJB4_AGABU	K5VW61_AGABU	K5WJB4	K5VW61	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	MaoC-like domain-containing protein.	0.974
K5WJB4_AGABU	K5WPV1_AGABU	K5WJB4	K5WPV1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.912
K5WJB4_AGABU	K5WS49_AGABU	K5WJB4	K5WS49	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acetyl-coenzyme A synthetase.	0.954
K5WJB4_AGABU	K5WWH0_AGABU	K5WJB4	K5WWH0	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Uncharacterized protein.	0.826
K5WJB4_AGABU	K5WZ39_AGABU	K5WJB4	K5WZ39	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.974
K5WJB4_AGABU	K5X2G9_AGABU	K5WJB4	K5X2G9	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.934
K5WJB4_AGABU	K5X7Q0_AGABU	K5WJB4	K5X7Q0	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.433