(12 nodes) HDR through Single Strand Annealing (SSA), and RecQ zinc-binding network (Habropoda laboriosa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	WH47_06876	ATP-dependent DNA helicase Q5. (1517 aa)
	WH47_05658	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (854 aa)
	WH47_04145	Replication protein A 14 kDa subunit. (118 aa)
	WH47_04116	Uncharacterized protein C16orf73 like protein. (474 aa)
	WH47_12019	Replication protein A 32 kDa subunit. (249 aa)
	WH47_00202	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (578 aa)
	WH47_04533	Tudor domain-containing protein 3. (680 aa)
	WH47_09938	Uncharacterized protein. (198 aa)
	WH47_06535	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa)
	WH47_05555	Bloom syndrome protein like protein. (1294 aa)
	WH47_08556	RecQ-mediated genome instability protein 1. (581 aa)
	WH47_08585	DNA repair protein RAD52 like protein. (292 aa)

Your Current Organism:

Habropoda laboriosa

NCBI taxonomy Id: 597456
Other names: H. laboriosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WH47_00202	WH47_04145	A0A0L7R1H7	A0A0L7QV34	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication protein A 14 kDa subunit.	0.999
WH47_00202	WH47_04533	A0A0L7R1H7	A0A0L7R281	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Tudor domain-containing protein 3.	0.842
WH47_00202	WH47_05555	A0A0L7R1H7	A0A0L7RF53	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Bloom syndrome protein like protein.	0.996
WH47_00202	WH47_05658	A0A0L7R1H7	A0A0L7QQI5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.928
WH47_00202	WH47_06535	A0A0L7R1H7	A0A0L7RD08	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.993
WH47_00202	WH47_06876	A0A0L7R1H7	A0A0L7QQE0	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	ATP-dependent DNA helicase Q5.	0.875
WH47_00202	WH47_08556	A0A0L7R1H7	A0A0L7RH73	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	RecQ-mediated genome instability protein 1.	0.991
WH47_00202	WH47_08585	A0A0L7R1H7	A0A0L7RHE1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA repair protein RAD52 like protein.	0.998
WH47_00202	WH47_09938	A0A0L7R1H7	A0A0L7R3G3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.987
WH47_00202	WH47_12019	A0A0L7R1H7	A0A0L7R123	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication protein A 32 kDa subunit.	0.987
WH47_04116	WH47_04145	A0A0L7QVE7	A0A0L7QV34	Uncharacterized protein C16orf73 like protein.	Replication protein A 14 kDa subunit.	0.973
WH47_04116	WH47_04533	A0A0L7QVE7	A0A0L7R281	Uncharacterized protein C16orf73 like protein.	Tudor domain-containing protein 3.	0.842
WH47_04116	WH47_05555	A0A0L7QVE7	A0A0L7RF53	Uncharacterized protein C16orf73 like protein.	Bloom syndrome protein like protein.	0.976
WH47_04116	WH47_05658	A0A0L7QVE7	A0A0L7QQI5	Uncharacterized protein C16orf73 like protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.875
WH47_04116	WH47_06535	A0A0L7QVE7	A0A0L7RD08	Uncharacterized protein C16orf73 like protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.944
WH47_04116	WH47_06876	A0A0L7QVE7	A0A0L7QQE0	Uncharacterized protein C16orf73 like protein.	ATP-dependent DNA helicase Q5.	0.875
WH47_04116	WH47_08556	A0A0L7QVE7	A0A0L7RH73	Uncharacterized protein C16orf73 like protein.	RecQ-mediated genome instability protein 1.	0.856
WH47_04116	WH47_08585	A0A0L7QVE7	A0A0L7RHE1	Uncharacterized protein C16orf73 like protein.	DNA repair protein RAD52 like protein.	0.974
WH47_04116	WH47_09938	A0A0L7QVE7	A0A0L7R3G3	Uncharacterized protein C16orf73 like protein.	Uncharacterized protein.	0.915
WH47_04116	WH47_12019	A0A0L7QVE7	A0A0L7R123	Uncharacterized protein C16orf73 like protein.	Replication protein A 32 kDa subunit.	0.915