(91 nodes) Regulation of cell migration network (Habropoda laboriosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WH47_08141	Leucine-rich repeat-containing protein 16A. (1462 aa)
	WH47_09210	Sortilin-related receptor. (2353 aa)
	WH47_07780	Integrin beta; Belongs to the integrin beta chain family. (794 aa)
	WH47_08510	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (174 aa)
	WH47_04368	Phosphoinositide phospholipase C. (1167 aa)
	WH47_06700	Protein sprint. (1377 aa)
	WH47_06620	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
	WH47_06098	GTP cyclohydrolase 1. (269 aa)
	WH47_05159	Laminin subunit alpha. (65 aa)
	WH47_05158	Laminin subunit alpha. (2726 aa)
	WH47_02986	Ubiquitin-conjugating enzyme E2 variant 2. (144 aa)
	WH47_05447	Protein patched. (1328 aa)
	WH47_01859	DnaJ like protein subfamily C member 13. (2177 aa)
	WH47_01817	Protein ECT2. (1002 aa)
	WH47_05214	Ras-related protein Rap-2c. (181 aa)
	WH47_04051	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (541 aa)
	WH47_03904	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (177 aa)
	WH47_03830	Protein FAM110B. (371 aa)
	WH47_04049	Neuroligin-4, Y-linked. (776 aa)
	WH47_04110	TLD domain-containing protein KIAA1609 like protein. (506 aa)
	WH47_04163	Non-specific serine/threonine protein kinase. (525 aa)
	WH47_04268	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
	WH47_03725	Protein spitz. (216 aa)
	WH47_03123	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (359 aa)
	WH47_04436	Fibroblast growth factor 17; Belongs to the heparin-binding growth factors family. (225 aa)
	WH47_02701	Tyrosine-protein phosphatase non-receptor type 4. (898 aa)
	WH47_00765	F-box/WD repeat-containing protein 1A. (538 aa)
	WH47_06273	Plexin-A1. (500 aa)
	WH47_04950	Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1994 aa)
	WH47_06723	Protein vein. (415 aa)
	WH47_06725	Pro-neuregulin-2, membrane-bound isoform. (187 aa)
	WH47_07935	Zinc transporter SLC39A7. (399 aa)
	WH47_07959	Netrin receptor UNC5B. (990 aa)
	WH47_08369	Down syndrome cell adhesion molecule-like protein Dscam2. (3669 aa)
	WH47_07856	FH1/FH2 domain-containing protein 3. (1142 aa)
	WH47_07859	Uncharacterized protein. (1747 aa)
	WH47_05924	Receptor protein-tyrosine kinase. (1373 aa)
	WH47_11000	Uncharacterized protein. (267 aa)
	WH47_09644	CCAAT/enhancer-binding protein. (362 aa)
	WH47_10887	Protein sprouty. (431 aa)
	WH47_09584	Vascular endothelial growth factor like protein; Belongs to the PDGF/VEGF growth factor family. (794 aa)
	WH47_10779	Roundabout like protein 2. (1339 aa)
	WH47_09544	Protein FAM89A. (476 aa)
	WH47_06515	Protein enabled like protein. (693 aa)
	WH47_06406	Leucine-rich repeats and immunoglobulin-like domains protein 2. (576 aa)
	WH47_03435	Shootin-1. (609 aa)
	WH47_03313	UBA domain-containing protein. (290 aa)
	WH47_03347	Ras-like GTP-binding protein Rho1. (192 aa)
	WH47_03311	E3 ubiquitin-protein ligase CBL. (454 aa)
	WH47_03251	Integrin beta; Belongs to the integrin beta chain family. (818 aa)
	WH47_03272	Semaphorin-1A; Belongs to the semaphorin family. (768 aa)
	WH47_03221	Non-specific serine/threonine protein kinase. (1146 aa)
	WH47_03240	Apoptosis 1 inhibitor. (401 aa)
	WH47_10387	Nuclear receptor coactivator 2. (1612 aa)
	WH47_11647	Protein FAM60A. (397 aa)
	WH47_09263	Semaphorin-1A; Belongs to the semaphorin family. (796 aa)
	WH47_11592	Tyrosine 3-monooxygenase. (528 aa)
	WH47_00381	Plexin-A4. (1534 aa)
	WH47_11818	Ras-responsive element-binding protein 1. (1456 aa)
	WH47_11780	TBC1 domain family member. (992 aa)
	WH47_00865	Hypoxia-inducible factor 1-alpha. (863 aa)
	WH47_08959	Heterogeneous nuclear ribonucleoprotein 27C. (396 aa)
	WH47_07315	ADP-ribosylation factor-like protein 1; Belongs to the small GTPase superfamily. Arf family. (164 aa)
	WH47_07328	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase. (428 aa)
	WH47_12815	Protein FAM102A. (677 aa)
	WH47_01018	Angio-associated migratory cell protein. (414 aa)
	WH47_01436	Origin recognition complex subunit 3. (652 aa)
	WH47_12789	Dual specificity mitogen-activated protein kinase kinase 7. (756 aa)
	WH47_12749	Mitogen-activated protein kinase. (593 aa)
	WH47_10301	Signal transducing adapter molecule 1. (491 aa)
	WH47_10200	Disintegrin and metalloproteinase domain-containing protein 10. (979 aa)
	WH47_10137	Protein virilizer. (1489 aa)
	WH47_00529	Paired amphipathic helix protein Sin3a. (1471 aa)
	WH47_02322	Cell division cycle and apoptosis regulator protein 1. (1083 aa)
	WH47_02389	SLIT-ROBO Rho GTPase-activating protein 1. (1206 aa)
	WH47_12542	Tyrosine kinase receptor Cad96Ca; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1667 aa)
	WH47_01556	Slit like protein 2 protein. (949 aa)
	WH47_00295	Dual specificity protein phosphatase 10. (330 aa)
	WH47_00330	A disintegrin and metalloproteinase with thrombospondin motifs 2. (757 aa)
	WH47_00294	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (258 aa)
	WH47_04707	Protein slit. (1394 aa)
	WH47_01353	Angiomotin. (1089 aa)
	WH47_09840	Plexin-B. (1970 aa)
	WH47_00047	annotation not available (422 aa)
	WH47_00366	Semaphorin-2A. (555 aa)
	WH47_12670	FGFR1 oncogene partner. (499 aa)
	WH47_00371	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (831 aa)
	WH47_10930	Serine/threonine-protein kinase mig-15. (1256 aa)
	WH47_11237	Semaphorin-5B. (1071 aa)
	WH47_08464	Bone morphogenetic protein 10. (337 aa)
	WH47_08472	Insulin receptor substrate 1-B. (1227 aa)

Your Current Organism:

Habropoda laboriosa

NCBI taxonomy Id: 597456
Other names: H. laboriosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WH47_00047	WH47_00381	A0A0L7QJS4	A0A0L7R8Y7	annotation not available	Plexin-A4.	0.470
WH47_00047	WH47_00865	A0A0L7QJS4	A0A0L7R7C1	annotation not available	Hypoxia-inducible factor 1-alpha.	0.487
WH47_00047	WH47_03240	A0A0L7QJS4	A0A0L7RAY5	annotation not available	Apoptosis 1 inhibitor.	0.756
WH47_00047	WH47_03251	A0A0L7QJS4	A0A0L7RB76	annotation not available	Integrin beta; Belongs to the integrin beta chain family.	0.614
WH47_00047	WH47_03347	A0A0L7QJS4	A0A0L7RBE8	annotation not available	Ras-like GTP-binding protein Rho1.	0.525
WH47_00047	WH47_03904	A0A0L7QJS4	A0A0L7QUK5	annotation not available	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.563
WH47_00047	WH47_04163	A0A0L7QJS4	A0A0L7QV36	annotation not available	Non-specific serine/threonine protein kinase.	0.928
WH47_00047	WH47_04268	A0A0L7QJS4	A0A0L7QVD9	annotation not available	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family.	0.971
WH47_00047	WH47_04368	A0A0L7QJS4	A0A0L7QR48	annotation not available	Phosphoinositide phospholipase C.	0.918
WH47_00047	WH47_05924	A0A0L7QJS4	A0A0L7RET2	annotation not available	Receptor protein-tyrosine kinase.	0.516
WH47_00047	WH47_06273	A0A0L7QJS4	A0A0L7RJT2	annotation not available	Plexin-A1.	0.433
WH47_00047	WH47_07780	A0A0L7QJS4	A0A0L7QNK2	annotation not available	Integrin beta; Belongs to the integrin beta chain family.	0.614
WH47_00047	WH47_08472	A0A0L7QJS4	A0A0L7QN05	annotation not available	Insulin receptor substrate 1-B.	0.628
WH47_00047	WH47_09210	A0A0L7QJS4	A0A0L7QN67	annotation not available	Sortilin-related receptor.	0.668
WH47_00047	WH47_09840	A0A0L7QJS4	A0A0L7R3A5	annotation not available	Plexin-B.	0.436
WH47_00047	WH47_12749	A0A0L7QJS4	A0A0L7R4Z0	annotation not available	Mitogen-activated protein kinase.	0.623
WH47_00047	WH47_12789	A0A0L7QJS4	A0A0L7R527	annotation not available	Dual specificity mitogen-activated protein kinase kinase 7.	0.419
WH47_00047	WH47_12815	A0A0L7QJS4	A0A0L7R5H9	annotation not available	Protein FAM102A.	0.843
WH47_00294	WH47_03240	A0A0L7R1W1	A0A0L7RAY5	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Apoptosis 1 inhibitor.	0.491
WH47_00294	WH47_03251	A0A0L7R1W1	A0A0L7RB76	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Integrin beta; Belongs to the integrin beta chain family.	0.526