(54 nodes) Nucleotide excision repair network (Habropoda laboriosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WH47_03977	Replication factor C subunit 5. (329 aa)
	WH47_03910	Replication factor C subunit 4. (335 aa)
	WH47_03046	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
	WH47_06680	Cullin-4B; Belongs to the cullin family. (781 aa)
	WH47_06037	Chromatin accessibility complex protein 1. (174 aa)
	WH47_06101	TFIIH basal transcription factor complex helicase XPD subunit. (761 aa)
	WH47_09015	Uncharacterized protein. (154 aa)
	WH47_07767	Putative ATP-dependent RNA helicase DDX11. (731 aa)
	WH47_08135	DNA polymerase delta small subunit. (445 aa)
	WH47_08102	DNA polymerase delta small subunit. (448 aa)
	WH47_11370	DNA excision repair protein ERCC-6. (1044 aa)
	WH47_10589	DNA excision repair protein ERCC-1. (254 aa)
	WH47_11466	General transcription factor IIH subunit 1. (562 aa)
	WH47_00480	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa)
	WH47_09459	Putative bifunctional polynucleotide kinase/RNA ligase. (1155 aa)
	WH47_09788	DNA ligase. (2693 aa)
	WH47_12665	Replication factor C subunit 1. (927 aa)
	WH47_03608	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2166 aa)
	WH47_05466	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (338 aa)
	WH47_07578	Replication factor C subunit 2. (351 aa)
	WH47_06361	Replication factor C subunit 3. (355 aa)
	WH47_03491	Caltractin. (150 aa)
	WH47_03397	DNA repair protein complementing XP-A cells like protein. (274 aa)
	WH47_12320	DNA repair protein complementing XP-C cells like protein. (896 aa)
	WH47_11651	DNA polymerase epsilon subunit 3. (129 aa)
	WH47_09258	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (446 aa)
	WH47_07314	DNA polymerase. (1108 aa)
	WH47_12717	General transcription factor 3C polypeptide 6. (404 aa)
	WH47_12711	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (160 aa)
	WH47_10324	ATPase family AAA domain-containing protein 5. (1132 aa)
	WH47_00561	Cyclin-H; Belongs to the cyclin family. (455 aa)
	WH47_10025	Cyclin-dependent kinase 20. (331 aa)
	WH47_10016	General transcription factor IIH subunit 5. (67 aa)
	WH47_09938	Uncharacterized protein. (198 aa)
	WH47_09808	General transcription factor IIH subunit 3. (247 aa)
	WH47_04629	Coiled-coil domain-containing protein 94. (342 aa)
	WH47_04456	RING-box protein 1A. (110 aa)
	WH47_00215	DNA damage-binding protein 1. (1141 aa)
	WH47_00202	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (578 aa)
	WH47_12038	PRKR-interacting protein 1 like protein. (263 aa)
	WH47_12019	Replication protein A 32 kDa subunit. (249 aa)
	WH47_02395	Claspin like protein. (895 aa)
	WH47_03079	DNA polymerase epsilon subunit 4. (127 aa)
	WH47_01936	UV excision repair protein RAD23 like protein B. (365 aa)
	WH47_04755	DNA repair protein complementing XP-G cells. (1096 aa)
	WH47_02758	General transcription factor IIH subunit. (400 aa)
	WH47_04772	Uncharacterized protein. (568 aa)
	WH47_04771	Zinc finger protein 609. (934 aa)
	WH47_02738	Uncharacterized protein. (355 aa)
	WH47_02694	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (320 aa)
	WH47_02571	Spindle assembly abnormal protein 6 like protein. (664 aa)
	WH47_04116	Uncharacterized protein C16orf73 like protein. (474 aa)
	WH47_04145	Replication protein A 14 kDa subunit. (118 aa)
	WH47_03972	DNA excision repair protein haywire. (794 aa)

Your Current Organism:

Habropoda laboriosa

NCBI taxonomy Id: 597456
Other names: H. laboriosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WH47_00202	WH47_00215	A0A0L7R1H7	A0A0L7R1I9	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA damage-binding protein 1.	0.669
WH47_00202	WH47_00480	A0A0L7R1H7	A0A0L7QKB8	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.827
WH47_00202	WH47_01936	A0A0L7R1H7	A0A0L7QY16	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	UV excision repair protein RAD23 like protein B.	0.697
WH47_00202	WH47_02395	A0A0L7R1H7	A0A0L7R010	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Claspin like protein.	0.984
WH47_00202	WH47_02571	A0A0L7R1H7	A0A0L7QW73	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Spindle assembly abnormal protein 6 like protein.	0.915
WH47_00202	WH47_02738	A0A0L7R1H7	A0A0L7QXG5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.589
WH47_00202	WH47_03046	A0A0L7R1H7	A0A0L7QT91	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.974
WH47_00202	WH47_03079	A0A0L7R1H7	A0A0L7QYA3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase epsilon subunit 4.	0.634
WH47_00202	WH47_03397	A0A0L7R1H7	A0A0L7RBJ7	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA repair protein complementing XP-A cells like protein.	0.955
WH47_00202	WH47_03491	A0A0L7R1H7	A0A0L7RBX4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Caltractin.	0.635
WH47_00202	WH47_03608	A0A0L7R1H7	A0A0L7RHX3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.856
WH47_00202	WH47_03910	A0A0L7R1H7	A0A0L7QU14	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication factor C subunit 4.	0.879
WH47_00202	WH47_03972	A0A0L7R1H7	A0A0L7QUH7	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA excision repair protein haywire.	0.692
WH47_00202	WH47_03977	A0A0L7R1H7	A0A0L7QUI2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication factor C subunit 5.	0.843
WH47_00202	WH47_04145	A0A0L7R1H7	A0A0L7QV34	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication protein A 14 kDa subunit.	0.999
WH47_00202	WH47_04629	A0A0L7R1H7	A0A0L7R2H5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Coiled-coil domain-containing protein 94.	0.642
WH47_00202	WH47_04755	A0A0L7R1H7	A0A0L7QXK4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA repair protein complementing XP-G cells.	0.868
WH47_00202	WH47_06101	A0A0L7R1H7	A0A0L7QRM5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	TFIIH basal transcription factor complex helicase XPD subunit.	0.755
WH47_00202	WH47_06361	A0A0L7R1H7	A0A0L7RCN7	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication factor C subunit 3.	0.838
WH47_00202	WH47_06680	A0A0L7R1H7	A0A0L7QSG8	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Cullin-4B; Belongs to the cullin family.	0.617