(94 nodes) MAPK signaling pathway - fly network (Habropoda laboriosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WH47_06348	Protein lozenge. (629 aa)
	WH47_03474	Importin-7. (1025 aa)
	WH47_03497	Exportin-1. (974 aa)
	WH47_03345	Uncharacterized protein. (1855 aa)
	WH47_11162	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	WH47_12162	Uncharacterized protein. (1861 aa)
	WH47_11171	EF-hand domain-containing protein. (450 aa)
	WH47_11436	Protein son of sevenless. (1331 aa)
	WH47_10498	Dual specificity mitogen-activated protein kinase kinase dSOR1; Belongs to the protein kinase superfamily. (415 aa)
	WH47_11818	Ras-responsive element-binding protein 1. (1456 aa)
	WH47_11881	Kinase suppressor of Ras 2. (894 aa)
	WH47_12362	Uncharacterized protein. (236 aa)
	WH47_11834	Dual oxidase. (1406 aa)
	WH47_12364	Tyrosine-protein kinase receptor. (2495 aa)
	WH47_11919	Protein daughter of sevenless. (565 aa)
	WH47_00429	Ras-related protein Rac1. (151 aa)
	WH47_00796	Dual specificity mitogen-activated protein kinase kinase 6. (336 aa)
	WH47_10930	Serine/threonine-protein kinase mig-15. (1256 aa)
	WH47_11483	Ras GTPase-activating protein 1. (929 aa)
	WH47_11503	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (279 aa)
	WH47_11482	Ras-like protein 1. (317 aa)
	WH47_09030	Ras-GEF domain-containing family member 1B. (477 aa)
	WH47_09034	Nuclear receptor subfamily 2 group E member 1. (421 aa)
	WH47_09074	Nuclear receptor subfamily 2 group E member 1. (364 aa)
	WH47_09031	Ras-GEF domain-containing family member 1B. (121 aa)
	WH47_11343	C2H2-type domain-containing protein. (233 aa)
	WH47_09734	Transcription factor kayak. (421 aa)
	WH47_09154	Protein giant-lens. (347 aa)
	WH47_10481	Transcription factor AP-1. (263 aa)
	WH47_07769	Uncharacterized protein. (496 aa)
	WH47_07770	Mitogen-activated protein kinase kinase kinase 9. (1119 aa)
	WH47_07797	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (205 aa)
	WH47_07801	SHC-transforming protein 1. (443 aa)
	WH47_08009	Ras-related C3 botulinum toxin substrate 1. (195 aa)
	WH47_05733	Tyrosine-protein kinase. (432 aa)
	WH47_02987	Tyrosine-protein kinase. (507 aa)
	WH47_01797	Homeobox protein prospero. (157 aa)
	WH47_05419	Ubiquitin-conjugating enzyme E2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family. (85 aa)
	WH47_05190	Receptor protein-tyrosine kinase. (1428 aa)
	WH47_01796	Homeobox protein prospero. (1100 aa)
	WH47_01858	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. Belongs to the protein kinase superfamily. Tyr protein kinase family. (1122 aa)
	WH47_04051	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (541 aa)
	WH47_03769	Leucine-rich repeat-containing protein 4B. (511 aa)
	WH47_05299	Docking protein 2. (552 aa)
	WH47_03725	Protein spitz. (216 aa)
	WH47_01941	Tyrosine-protein kinase. (505 aa)
	WH47_02942	Ras GTPase-activating protein 3. (1071 aa)
	WH47_00780	Transgelin; Belongs to the calponin family. (1504 aa)
	WH47_01249	F-box-like/WD repeat-containing protein TBL1XR1. (512 aa)
	WH47_00295	Dual specificity protein phosphatase 10. (330 aa)
	WH47_00294	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (258 aa)
	WH47_04602	Ras-specific guanine nucleotide-releasing factor 2. (401 aa)
	WH47_09826	Optomotor-blind protein. (413 aa)
	WH47_09827	Optomotor-blind protein. (126 aa)
	WH47_09828	Optomotor-blind protein. (301 aa)
	WH47_09958	Serine/threonine-protein phosphatase. (309 aa)
	WH47_00664	PP2C_C domain-containing protein. (62 aa)
	WH47_00663	Protein phosphatase 1B. (309 aa)
	WH47_12749	Mitogen-activated protein kinase. (593 aa)
	WH47_12789	Dual specificity mitogen-activated protein kinase kinase 7. (756 aa)
	WH47_01028	Ubiquitin carboxyl-terminal hydrolase CYLD. (544 aa)
	WH47_12820	RAF proto-oncogene serine/threonine-protein kinase. (728 aa)
	WH47_07224	Torso-like protein. (343 aa)
	WH47_08855	Cyclic AMP-dependent transcription factor ATF-2. (532 aa)
	WH47_00932	Ras-like GTP-binding protein RhoL. (183 aa)
	WH47_00415	Uncharacterized protein. (65 aa)
	WH47_00435	Protein decapentaplegic. (390 aa)
	WH47_00414	TNFR-Cys domain-containing protein. (226 aa)
	WH47_00419	Ets DNA-binding protein pokkuri. (472 aa)
	WH47_01367	Uncharacterized protein. (413 aa)
	WH47_01366	Uncharacterized protein. (577 aa)
	WH47_04972	Zinc finger protein Xfin. (877 aa)
	WH47_05015	Protein bride of sevenless. (859 aa)
	WH47_02175	Mitogen-activated protein kinase. (365 aa)
	WH47_07196	Mitogen-activated protein kinase kinase kinase 4. (1335 aa)
	WH47_06814	14-3-3 protein zeta; Belongs to the 14-3-3 family. (383 aa)
	WH47_06723	Protein vein. (415 aa)
	WH47_03612	Transforming protein p68/c-ets-1. (742 aa)
	WH47_06725	Pro-neuregulin-2, membrane-bound isoform. (187 aa)
	WH47_07947	Striatin-4. (710 aa)
	WH47_00609	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (285 aa)
	WH47_08524	Mitogen-activated protein kinase kinase kinase 7. (536 aa)
	WH47_07038	Connector enhancer of kinase suppressor of ras 3. (1609 aa)
	WH47_05489	Transducin-like enhancer protein 4. (747 aa)
	WH47_05508	Protein groucho. (712 aa)
	WH47_05490	Transducin-like enhancer protein 3. (859 aa)
	WH47_09350	Protein E(Sev)2B. (267 aa)
	WH47_05922	TNF receptor-associated factor 6. (380 aa)
	WH47_10887	Protein sprouty. (431 aa)
	WH47_06562	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
	WH47_06447	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (582 aa)
	WH47_06345	Protein lozenge. (478 aa)
	WH47_06344	Protein lozenge. (601 aa)
	WH47_10675	Myocyte-specific enhancer factor 2. (620 aa)

Your Current Organism:

Habropoda laboriosa

NCBI taxonomy Id: 597456
Other names: H. laboriosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WH47_00294	WH47_01249	A0A0L7R1W1	A0A0L7QZ76	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	F-box-like/WD repeat-containing protein TBL1XR1.	0.501
WH47_00294	WH47_01941	A0A0L7R1W1	A0A0L7QY19	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein kinase.	0.412
WH47_00294	WH47_02175	A0A0L7R1W1	A0A0L7RJA8	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.953
WH47_00294	WH47_02987	A0A0L7R1W1	A0A0L7QSY0	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein kinase.	0.412
WH47_00294	WH47_04051	A0A0L7R1W1	A0A0L7QUH4	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.634
WH47_00294	WH47_05733	A0A0L7R1W1	A0A0L7QQP9	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein kinase.	0.408
WH47_00294	WH47_06814	A0A0L7R1W1	A0A0L7RIW3	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	14-3-3 protein zeta; Belongs to the 14-3-3 family.	0.616
WH47_00294	WH47_07769	A0A0L7R1W1	A0A0L7QNG8	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.574
WH47_00294	WH47_07770	A0A0L7R1W1	A0A0L7QNJ2	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase kinase kinase 9.	0.574
WH47_00294	WH47_08524	A0A0L7R1W1	A0A0L7RH64	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase kinase kinase 7.	0.479
WH47_00294	WH47_08855	A0A0L7R1W1	A0A0L7R6E5	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Cyclic AMP-dependent transcription factor ATF-2.	0.465
WH47_00294	WH47_09734	A0A0L7R1W1	A0A0L7QM80	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transcription factor kayak.	0.616
WH47_00294	WH47_10481	A0A0L7R1W1	A0A0L7QN64	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transcription factor AP-1.	0.565
WH47_00294	WH47_10498	A0A0L7R1W1	A0A0L7R9K2	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity mitogen-activated protein kinase kinase dSOR1; Belongs to the protein kinase superfamily.	0.423
WH47_00294	WH47_12362	A0A0L7R1W1	A0A0L7R7T3	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.405
WH47_00294	WH47_12364	A0A0L7R1W1	A0A0L7R7T2	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein kinase receptor.	0.405
WH47_00294	WH47_12749	A0A0L7R1W1	A0A0L7R4Z0	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.988
WH47_00294	WH47_12789	A0A0L7R1W1	A0A0L7R527	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity mitogen-activated protein kinase kinase 7.	0.711
WH47_00295	WH47_01249	A0A0L7R1R1	A0A0L7QZ76	Dual specificity protein phosphatase 10.	F-box-like/WD repeat-containing protein TBL1XR1.	0.501
WH47_00295	WH47_01941	A0A0L7R1R1	A0A0L7QY19	Dual specificity protein phosphatase 10.	Tyrosine-protein kinase.	0.412