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tuf tuf rpmG rpmG rplK rplK rplA rplA rplJ rplJ rplL rplL rpsL rpsL rpsG rpsG fusA fusA rpsU rpsU rplT rplT rpmI rpmI rpmF rpmF rpmH rpmH rpsO rpsO rplY rplY rplI rplI rpmE rpmE rpsR rpsR rpsF rpsF rpsT rpsT rpmA rpmA rplU rplU rpsI rpsI rplM rplM rpsP rpsP rpmB rpmB infA infA map map secY secY rplO rplO rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ rplQ rplQ rpsD rpsD rpsK rpsK rpsM rpsM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tufTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa)
rpmGRibosomal protein L33; Identified by match to protein family HMM PF00471; match to protein family HMM TIGR01023; Belongs to the bacterial ribosomal protein bL33 family. (50 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (159 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (124 aa)
rpsLRibosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (127 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (693 aa)
rpsURibosomal protein S21; Identified by match to protein family HMM PF01165; match to protein family HMM TIGR00030; Belongs to the bacterial ribosomal protein bS21 family. (70 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (116 aa)
rpmIRibosomal protein L35; Identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rpmFRibosomal protein L32; Identified by match to protein family HMM PF01783; match to protein family HMM TIGR01031; Belongs to the bacterial ribosomal protein bL32 family. (49 aa)
rpmHRibosomal protein L34; Identified by match to protein family HMM PF00468; match to protein family HMM TIGR01030; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
rpsORibosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (91 aa)
rplYRibosomal protein L25, Ctc-form; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (178 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (146 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (66 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (94 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (111 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (90 aa)
rpmARibosomal protein L27; Identified by match to protein family HMM PF01016; match to protein family HMM TIGR00062; Belongs to the bacterial ribosomal protein bL27 family. (87 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpsIRibosomal protein S9; Identified by match to protein family HMM PF00380; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (140 aa)
rpsPRibosomal protein S16; Identified by match to protein family HMM PF00886; match to protein family HMM TIGR00002; Belongs to the bacterial ribosomal protein bS16 family. (81 aa)
rpmBRibosomal protein L28; Identified by match to protein family HMM PF00830; match to protein family HMM TIGR00009; Belongs to the bacterial ribosomal protein bL28 family. (61 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
mapMethionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (252 aa)
secYPreprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (419 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (130 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (158 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (121 aa)
rplF50s ribosomal protein l6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa)
rpsNRibosomal protein S14p/S29e; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (181 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (83 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (81 aa)
rpmCRibosomal protein L29; Identified by match to protein family HMM PF00831; match to protein family HMM TIGR00012; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (240 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (106 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (93 aa)
rplDRibosomal protein L4/L1 family; Forms part of the polypeptide exit tunnel. (193 aa)
rplCRibosomal protein L3; Identified by match to protein family HMM PF00297. (191 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rplQRibosomal protein L17; Identified by match to protein family HMM PF01196; match to protein family HMM TIGR00059. (122 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (130 aa)
rpsMRibosomal protein S13p/S18e; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa)
Your Current Organism:
Nautilia profundicola
NCBI taxonomy Id: 598659
Other names: N. profundicola AmH, Nautilia profundicola AmH, Nautilia profundicola str. AmH, Nautilia profundicola strain AmH, Nautilia sp. AmH, epsilon proteobacterium AmH
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