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SRP54 SRP54 GAB3 GAB3 CCR7 CCR7 IL19 IL19 MED1 MED1 GATA3 GATA3 SP3 SP3 CSF1 CSF1 NRROS NRROS EPHA2 EPHA2 TSPAN2 TSPAN2 FARP2 FARP2 KIT KIT CREB1 CREB1 CASP8 CASP8 U3JNE7_FICAL U3JNE7_FICAL CASP10 CASP10 ITGB6 ITGB6 CD4 CD4 PAFAH1B1 PAFAH1B1 IL15 IL15 OCSTAMP OCSTAMP U3JRL1_FICAL U3JRL1_FICAL PSEN1 PSEN1 SRC SRC DCSTAMP DCSTAMP FOS FOS BATF BATF CEBPA CEBPA CSF1R CSF1R LECT2 LECT2 TNFSF11 TNFSF11 NKX2-3 NKX2-3 SH3PXD2A SH3PXD2A TGFBR2 TGFBR2 SNX10 SNX10 ITGB8 ITGB8 CCL19-2 CCL19-2 ATP6AP1 ATP6AP1 LRRK1 LRRK1 CALCR CALCR CAMK4 CAMK4 GLO1 GLO1 VEGFA VEGFA OSTM1 OSTM1 LBR LBR APP APP CTNNB1 CTNNB1 LEF1 LEF1 BATF3 BATF3 SIRT1 SIRT1 TNFRSF11A TNFRSF11A JAGN1 JAGN1 DHRS7B DHRS7B FAM20C FAM20C EIF2AK1 EIF2AK1 EFNA2 EFNA2 GPR68 GPR68 SOCS1 SOCS1 GPR183 GPR183
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
GAB3GRB2 associated binding protein 3. (595 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
IL19Interleukin 19. (176 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
GATA3GATA binding protein 3. (444 aa)
SP3Sp3 transcription factor. (690 aa)
CSF1Uncharacterized protein. (488 aa)
NRROSNegative regulator of reactive oxygen species. (688 aa)
EPHA2EPH receptor A2. (923 aa)
TSPAN2Tetraspanin. (182 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1029 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (955 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (507 aa)
U3JNE7_FICALUncharacterized protein; Belongs to the peptidase C14A family. (468 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (484 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (791 aa)
CD4Uncharacterized protein. (487 aa)
PAFAH1B1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (184 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (437 aa)
U3JRL1_FICALMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (497 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SRCTyrosine-protein kinase. (539 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (472 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (371 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
CEBPACCAAT/enhancer-binding protein. (321 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (968 aa)
LECT2Uncharacterized protein. (325 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (298 aa)
NKX2-3NK2 homeobox 3. (309 aa)
SH3PXD2ASH3 and PX domains 2A. (1040 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
SNX10Sorting nexin 10. (201 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
CCL19-2SCY domain-containing protein. (96 aa)
ATP6AP1Uncharacterized protein. (428 aa)
LRRK1Leucine rich repeat kinase 1. (1999 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (469 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (324 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (179 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (177 aa)
OSTM1Osteoclastogenesis associated transmembrane protein 1. (220 aa)
LBRLamin B receptor. (638 aa)
APPAmyloid beta precursor protein. (738 aa)
CTNNB1Catenin beta 1. (781 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (137 aa)
SIRT1Sirtuin 1. (645 aa)
TNFRSF11ATNF receptor superfamily member 11a. (639 aa)
JAGN1Jagunal homolog 1. (183 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (560 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (636 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (159 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (355 aa)
Your Current Organism:
Ficedula albicollis
NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher
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