STRINGSTRING
MVD MVD RUSC1 RUSC1 PRKAA1 PRKAA1 FDFT1 FDFT1 SQLE SQLE R3HDM4 R3HDM4 INSIG2 INSIG2 LSS LSS PRKAA2 PRKAA2 DHCR24 DHCR24 LBR LBR NSDHL NSDHL MSMO1 MSMO1 HMGCS1 HMGCS1 CYB5R2 CYB5R2 CYP51A1 CYP51A1 HMGCR HMGCR CFTR CFTR DHCR7 DHCR7 MVK MVK IDI1 IDI1 INSIG1 INSIG1 G6PD G6PD ERG28 ERG28 APOA1 APOA1 SC5D SC5D APOA5 APOA5 CYB5R3 CYB5R3 HMGCS2 HMGCS2 HSD17B7 HSD17B7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (409 aa)
RUSC1RUN and SH3 domain containing 1. (766 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (418 aa)
SQLESqualene epoxidase. (575 aa)
R3HDM4R3H domain containing 4. (241 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (666 aa)
PRKAA2Non-specific serine/threonine protein kinase. (523 aa)
DHCR2424-dehydrocholesterol reductase. (550 aa)
LBRLamin B receptor. (638 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (297 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (522 aa)
CYB5R2NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (250 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (404 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1403 aa)
DHCR77-dehydrocholesterol reductase. (477 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
IDI1Nudix hydrolase domain-containing protein. (227 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (272 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (474 aa)
ERG28Ergosterol biosynthesis 28 homolog. (186 aa)
APOA1Apolipoprotein A1. (266 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (302 aa)
APOA5Apolipoprotein A5. (322 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (504 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (332 aa)
Your Current Organism:
Ficedula albicollis
NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher
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