node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COQ6 | COQ7 | ENSFALP00000006518 | ENSFALP00000014656 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. | 0.739 |
COQ6 | FMO1 | ENSFALP00000006518 | ENSFALP00000008202 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Dimethylaniline monooxygenase [N-oxide-forming]. | 0.418 |
COQ6 | FMO4 | ENSFALP00000006518 | ENSFALP00000008186 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Dimethylaniline monooxygenase [N-oxide-forming]. | 0.418 |
COQ6 | FMO5 | ENSFALP00000006518 | ENSFALP00000003951 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Dimethylaniline monooxygenase [N-oxide-forming]. | 0.418 |
COQ6 | KMO | ENSFALP00000006518 | ENSFALP00000013905 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.532 |
COQ6 | U3KLC6_FICAL | ENSFALP00000006518 | ENSFALP00000015830 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Flavin-containing monooxygenase. | 0.418 |
COQ7 | COQ6 | ENSFALP00000014656 | ENSFALP00000006518 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.739 |
CYP26B1 | CYP7B1 | ENSFALP00000011370 | ENSFALP00000005717 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.679 |
CYP26B1 | SQLE | ENSFALP00000011370 | ENSFALP00000002638 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | Squalene epoxidase. | 0.615 |
CYP27A1 | CYP46A1 | ENSFALP00000004330 | ENSFALP00000002721 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.927 |
CYP27A1 | CYP7A1 | ENSFALP00000004330 | ENSFALP00000010784 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.952 |
CYP27A1 | CYP7B1 | ENSFALP00000004330 | ENSFALP00000005717 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.950 |
CYP46A1 | CYP27A1 | ENSFALP00000002721 | ENSFALP00000004330 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.927 |
CYP46A1 | CYP7A1 | ENSFALP00000002721 | ENSFALP00000010784 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.941 |
CYP46A1 | CYP7B1 | ENSFALP00000002721 | ENSFALP00000005717 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.445 |
CYP46A1 | SQLE | ENSFALP00000002721 | ENSFALP00000002638 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. | Squalene epoxidase. | 0.615 |
CYP51A1 | SQLE | ENSFALP00000010929 | ENSFALP00000002638 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | Squalene epoxidase. | 0.987 |
CYP7A1 | CYP27A1 | ENSFALP00000010784 | ENSFALP00000004330 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.952 |
CYP7A1 | CYP46A1 | ENSFALP00000010784 | ENSFALP00000002721 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.941 |
CYP7A1 | SQLE | ENSFALP00000010784 | ENSFALP00000002638 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Squalene epoxidase. | 0.696 |